Transparent Labs WellnessSeries Immune

Product Overview

Immune health has traditionally been an afterthought for many active individuals, but now it’s at the forefront of priorities for just about everyone. Transparent Labs Immune features an unparalleled lineup of clinically studied ingredients, such as EpiCor, CurcuWIN Ultra+, Gingever, and L-OptiZinc, that facilitate the two basic types of immune defense responses: Innate and adaptive.

We went above and beyond to create an all-star supplement for immune support that helps you stay prepared for the pesky invasive challenges life throws at you. (Be sure to check out the research behind this knockout formula below!)

Ingredient Profile

Serving Size: 4 Capsules
Servings Per Container: 30

EpiCor remains one of the most promising immune-promoting ingredients on the market. By using an innovative anaerobic fermentation process, EpiCor provides a bioactive-rich fermentate from dried baker’s yeast (Saccharomyces cerevisiae).

In contrast to pure beta-glucans and yeast cell wall preparations, EpiCor yeast fermentate contains an array of bioactive metabolites, vitamins, phospholipids, cell wall constituents, and stress-induced defense mediators. After ingestion, EpiCor is rapidly assimilated and activates immune-modulators like natural killer cells while also boosting antioxidant capacity [1]A growing body of clinical research suggests that EpiCor yeast fermentate can help support innate and adaptive immune responses, thereby conferring protection against health challenges when the body is stressed [2, 3].

Ganoderma lucidum, also known as the reishi mushroom, is a large, robust mushroom that has been used as an immune- and liver-revitalizing agent for centuries in Traditional Chinese Medicine [4]. Research suggests that reishi mushrooms contain protein and triterpene constituents, specifically ganodermic acids, with potent immunostimulating and hepatoprotective properties [5].

Clinical evidence has shown that ganodermic acids inhibit the release of histamine in mast cells (meaning ganodermic acids work to reduce pro-inflammatory markers in susceptible body tissues) [6]. The distinct proteins in reishi mushrooms also appear to preserve liver function through antioxidant mechanisms [7].

Curcuma longa (turmeric) is a flowering plant whose roots and rhizomes are among the richest natural sources of promising phytochemicals called curcuminoids. The vibrant golden color of turmeric spice derives from these curcuminoids, notably curcumin. Clinical evidence suggests that curcuminoids have ubiquitous roles throughout the body, particularly within the immune system, nervous system, and musculoskeletal system [8].

Vis-à-vis immune function, a recent double-blind, placebo-controlled trial found that subjects taking a curcumin supplement had significantly greater reductions in serum concentrations of proinflammatory cytokines compared to those taking a placebo [9]. These results are congruent with a current meta-analysis of clinical studies substantiating the anti-inflammatory properties of curcumin [10].

The catch is that curcuminoids — especially curcumin — have poor oral bioavailability, ostensibly limiting the therapeutic potential of many turmeric supplements on the market [11]. However, recent advancements in biotechnology have made it possible to circumvent the oral absorption issues with curcuminoids, resulting in exceptional bioavailability.

CurcuWIN Ultra+ provides highly bioavailable curcuminoids through OmniActive’s proprietary Ultrasol technology, allowing significantly up to 144x more curcumin to reach systemic circulation than standard curcumin formulations ^[12]. In turn, this translates to more robust immune support and inflammation protection.

Ginger (Zingiber officinalis) is a flowering plant that has also been used as an herbal anti-nausea and indigestion remedy throughout history. The roots of the plant are a rich source of fragrant polyphenols — known as gingerols — that give ginger its characteristic spice and aroma [13].

It is now well-established that several gingerols, notably the congener 6-gingerol, have significant antioxidant and immunomodulatory properties throughout the body [14, 15]. As one of the most potent ginger root extracts available, Gingever provides a hefty 10% gingerols by mass, ensuring an efficacious dose of these key constituents in every serving of Transparent Labs Immune.

Touted as “the great representative of polyphenols,” quercetin is a secondary plant metabolite found in a range of fruits and vegetables [16]. It’s a vital micronutrient that quenches oxidative stress by neutralizing reactive oxygen species and reactive nitrogen species that accumulate in cells. In so doing, quercetin can help attenuate inflammation associated with allergic responses, stimulate immune function, and alleviate cellular toxicity [17, 18].

L-OptiZinc is an aptly-named zinc formulation, as zinc-L-methionine, optimized for absorption and distribution throughout the body. Much like magnesium, zinc is an essential mineral that’s typically lacking in modern diets [19]. As such, supplementing with L-OptiZinc can help ensure you get plenty of this crucial trace mineral.

Zinc deficiency is well-known to disrupt immune function, fertility, sex hormone production, and mood [20]. Contrarily, supplementing with zinc may reduce the severity of respiratory tract infections and shorten their duration [21].

Magnesium is an essential cofactor (think: “assisting molecule”) for an estimated 300+ biochemical reactions throughout the body [22]. For example, magnesium is a major constituent of bone minerals and a mediator of immune function, skeletal muscle contraction, and nerve impulse transmission.

Recent studies suggest that the average person does not meet the recommended daily intake for magnesium and may be at risk of (sub)clinical hypomagnesemia [23, 24]. Therefore, bioavailable magnesium supplementation is becoming an important staple for overall health and wellness.

Piperine, the primary bioactive constituent in black pepper (Piper nigrum), is known as a “bioenhancer” since it helps with the bioavailability of molecules that are typically poorly absorbed or extensively metabolized in the liver [25, 26]. Hence, patented BioPerine assists with the absorption and efficacy of other active ingredients in Transparent Labs Immune.

As a crucial water-soluble antioxidant, vitamin C plays many important roles throughout the immune, nervous, and cardiovascular systems. Studies continue to demonstrate that supplementing with vitamin C can reduce the severity and duration of cold and flu symptoms and may hold promise as an adjuvant to existing treatments [27, 28].

Vitamin D3 is structurally similar to cholesterol, the parent molecule of all steroid hormones in the human body. The body has various enzymes in the liver and kidneys that convert vitamin D3 to hydroxylated derivatives, notably calcitriol — a biologically active form of vitamin D. The rate at which calcitriol is synthesized is limited by vitamin D3 availability. As such, it’s best to supplement with vitamin D3 as opposed to calcitriol itself.

Biologically active vitamin D performs a multitude of roles in the body and is particularly important for proper absorption of the minerals calcium, iron, magnesium, phosphate, and zinc [29]. Calcitriol also regulates bone growth and regeneration, as well as immune, cardiac, and neuromuscular functions [30].

Vitamin B12 (cobalamin) is the most complex vitamin in terms of its chemical structure and metabolic functions. Vitamin B12 is involved in numerous physiological processes by acting as a cofactor for specific enzymes. Low vitamin B12 levels are known to impair cellular/DNA repair damage and T-cell responses to toxicity, signaling the importance of consuming ample amounts of this micronutrient [31].