An essential nutrient required for a myriad of functions, choline should be part of a well-rounded diet. Studies indicate that only about 10% of Americans consume enough dietary choline.[39]
Additionally, endurance athletes, and people who regularly consume alcohol, are at risk of choline deficiency. Now is an important time to admit that you're probably among the looming majority of choline neglectors.
Benefits
Brain
Choline is classified as an essential nutrient. While it can be synthesized within the body, we only produce insufficient amounts -- and doing so compromises the structural integrity of our cells. Phosphatidylcholine helps to compose the lipid membrane of cells, and when enough free choline isn't available, your body breaks this structure down to obtain the compound.
This is an interesting and vicious example of biological self-immolation -- a process that favors short-term performance at the behest of compromised long-term health. Supplementing choline into your diet may circumnavigate this issue. In other words, you can have your cake and eat it too. Below are a few benefits:
-
Improved global cognitive function
Choline is a precursor to the neurotransmitter acetylcholine, which is implicated in memory, intelligence, and mood. Animal studies suggest that high choline intake protects the brain's ability to form and recall memories despite the progression of age. In particular, "choline-supplemented older mice performed as well as young three-month-old mice."[31] The supplemented mice were also observed to have increased communication within the hippocampus.
-
Heart health and depression
Dietary choline is an essential source of methyl groups for many biological processes. For example, one metabolite of choline is trimethylglycine, or betaine (an ingredient in many pre-workout formulations), which participates in the production of SAM-e. Deficits of SAM-e are implicated in Alzheimer's disease, diabetes, heart disease, depression, and more.[27,28,29]
-
Anti-inflammatory
Higher dietary intake of choline is associated with lower inflammatory markers, and reduced symptoms of allergic rhinitis.[30]
Body
Acetylcholine is the most abundant neurotransmitter in the entire body, responsible for muscle contractions. "Consumption of supplemental choline can also increase the release of acetylcholine from nerve endings, including those that cause skeletal muscle to contract," according to a study published in Pharmalogical Reviews.[35]
Intense exercise
Unsurprisingly, intensive exercise results in a significant reduction in plasma choline levels, particularly prolonged and strenuous activity. After two hours of exercise, participants lost about 40% to 50% of free choline.
The good news is that ingesting choline pre-exercise can not only prevent this loss, but raise it above baseline for up to two hours post-exercise (2g of free choline was used in this study).[36]
In one study, individual performance was enhanced after choline supplementation compared to when the same individuals consumed a placebo.[37]
Choline sources
Many different choline formulations are available. There is a huge price disparity between certain supplements. Some are very cheap and others comparatively expensive. Naturally, you would want potency to increase along with price -- which the expensive ones certainly do -- but the real advantage of CDP-choline (expensive) over something like choline citrate (cheap) is its fanciness.
Choline Molecule
All choline precursors follow the same protocol: choline bound with some other chemical. For the cheap supplements, the choline is bound to another relatively inactive compound, so you're essentially getting just choline. But the expensive acetylcholine precursors consist of choline bound with other biologically active compounds that enhance absorption or produce other reactions that work to multiply choline's effects. Below is a list of the most common formulations. Each has its own particular benefits and detractions.
Choline bitartrate and choline citrate
These two are thrown together because they are so similar in the most important respects. Simple choline salts are cheap as dirt, but have questionable potency. Users have complained of stomach aches because of the amount consumed for desired effects, but you get what you pay for.
You may ask why these compounds are not very potent. Technically free choline, due to its polarity, would not be able to cross the blood-brain barrier. While we have a choline transport system, it's sadly inefficient and seems to decline with age.
CDP-choline
Hands down, this is the best choline source available. Multitudes of animal research and fair amounts of human research attest to the efficacy of CDP-choline, or citicoline.
Human studies have shown neuro-protective and neuro-regenerative effects
and a proven efficacy for improving the following conditions:
-
Alzheimer's disease
-
Parkinson's disease
-
Age-related memory and learning deficits
-
Stroke
-
Drug addiction
-
Glaucoma-induced ocular damage
-
Traumatic brain injury
-
Schizophrenia
CDP-choline is more expensive than bitartrate and citrate, but generally cheaper than alpha-GPC.
Alpha-GPC
A natural choline compound already swimming around your brain and derived from soy lecithin, this is probably the most bioavailable choline source, but also the most expensive. You should expect similar effects as you would with citicoline. One study found alpha-GPC more effective than citicoline for vascular dementia[15], with another showing higher plasma choline levels after alpha administration over CDP.
As you can see, alpha-GPC and CDP-choline are the two rock stars of acetylcholine precursors. Some studies suggest GPC is better, but there is just so much more research attesting to the efficacy of CDP-choline.
Other enhancers
Choline metabolism
You may notice by now that you need an acetyl to go with that lonely choline for magic to happen. That is absolutely true, and a great addition to a basic choline stack is ALCAR, or acetylcarnitine.
ALCAR
Acetyl L-carnitine is great stuff -- no argument. It's naturally produced in your body during strenuous exercise, and supplementation has dramatic effects, irrespective of its role in energy production.
-
By donating the acetyl group, ALCAR enhances acetylcholine production.
-
Both ALCAR and L-carnitine stimulate muscle production.
-
It stimulates nerve growth factor release.
-
Improves neuronal membrane fluidity (more communication).
-
Acetylcholine receptor agonist.
-
Increases the utilization of glucose, ketone bodies, and lipid substrates in the brain.
-
Improves choline uptake (thus acetylcholine synthesis).[21]
Aside from the pro-cognitive effects, ALCAR may have overall lifespan enhancing effects. Simply put, our mitochondria (powerhouse of cells) have to put up with decades of abuse, and they produce toxic reactive oxygen species (ROS), or free radicals. A damaged mitochondrion is leaky and our current understanding of the aging process points many fingers toward this compromised structure. "Acetyl-L-carnitine, a high-energy mitochondrial substrate, appears to reverse many age-associated deficits in cellular function."[16]
DMAE
This compound is frequently cited as a choline precursor, but it probably has little if anything to do with acetylcholine production.[25] Rather, DMAE seems to bind with phospholipids that compose cellular membranes. Where phosphatidylcholine would be, phosphatidyl-dimethylaminoethanol now takes its place, increasing membrane permeability and antioxidant capacity.[26]
Centrophenoxine
Also known as meclofenoxate, this is basically supercharged DMAE (specifically an ester of DMAE). Though limited evidence suggests mental stimulation and memory improvement, it has beneficial phospholipid properties with little direct effects on choline or acetylcholine.
Racetams
Bacon and eggs
If you are taking any of the racetam derivatives, then you probably know that the cholinergic system is involved with their effects. Many people believe this means your brain on piracetam, for example, will consume more choline than otherwise. Two studies, conducted on rats, assert that piracetam and oxiracetam reduces hippocampal acetylcholine levels.[32,33] Regardless, other animal studies suggest a synergistic effect with racetams and a choline source.[34] For many, choline and piracetam is like bacon and eggs -- it just feels right for them to keep each other company.
Consider Noopept
Although it's not technically a "racetam", Noopept is structurally very similar, and yields a piracetam-like effect, but many think it's even better.
It stacks incredibly well with choline -- you can read more on the Noopept blog post linked just above.
Choline intake
According to the Institute of Medicine, the adequate intake (AI) of choline is 425mg/day for women and 550mg/day for men. As a reference, any of the choline salts (bitartrate, citrate) are about 41% free choline. So something over 1000mg should satisfy your minimum daily requirements.
Remember that choline is present in many foods, most prominently in beef, beef liver, and eggs.
Hands down, CDP choline (citicoline) is the best choline source available.
It's difficult to determine what the optimal dose would be for cognitive function. The cholinergic system is tricky, and everyone is different. With that said, the most common dose for all choline precursors falls somewhere between 250mg to 2000mg.
None of these statements constitute medical advice. These supplements are not regulated or approved by the FDA. You should consult a medical doctor before embarking on self-treatment.
Side effects
The side effects of choline supplementation seem few, mild, and transient. As mentioned above, people occasionally complain of stomach discomfort. If you happen to have the rare genetic disorder, trimethylaminuria, consuming too much choline will make your body exude the odor of overripe fish.
References
- Alvarez, XA; Methods and Findings in Experimental and Clinical Pharmacology; "Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity and cerebral perfusion;" 1999
- Secades, JJ; Methods and Findings in Experimental and Clinical Pharmacology; "CDP-choline: pharmacological and clinical review;" 1995
- Marti Masso, JF; Clinical Therapeutics; "Citicoline in the treatment of Parkinson's disease;" 1991
- Cubells, JM; Clinical Therapeutics; "Clinical trial on the use of cytidine diphosphate choline in Parkinson's disease;" 1988
- Babb, SM, et. al.; Psychopharmacology; "Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study;" 2002
- Antoni D?valos, MD, et. al.; American Heart Association; "Oral Citicoline in Acute Ischemic Stroke An Individual Patient Data Pooling Analysis of Clinical Trials;" 2002
- Lukas, SE, et. al; Psychopharmacology; "Effects of short-term citicoline treatment on acute cocaine intoxication and cardiovascular effects;" 2001
- Renshaw, PF, et. al.; Psychopharmacology; "Decreased activity of brain phospholipid metabolic enzymes in human users of cocaine and methamphetamine;" 1999
- Renshaw, PF, et. al.; Psychopharmacology; "Short-term treatment with citicoline (CDP-choline) attenuates some measures of craving in cocaine-dependent subjects: a preliminary report;" 1999
- Parisi, V, et. al.; Progress in Brain Research; "Evidence of the neuroprotective role of citicoline in glaucoma atients;" 2008
- Secades, JJ, et. al.; Methods and Findings in Experimental and Clinical Pharmacology; "CDP-choline: pharmacological and clinical review;" 1995
- Zafonte, R.; Journal of Neurotrauma; "The citicoline brain injury treatment (COBRIT) trial: Design and methods;" 2009
- Deutsch, SI, et. al.; Clinical Neuropharmacology; "First administration of cytidine diphosphocholine and galantamine in schizophrenia: A sustained alpha7 nicotinic agonist strategy;" 2008
- De Jesus Moreno Moreno, M; Clinical Therapeutics; "Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: A multicenter, double-blind, randomized, placebo-controlled trial;" 2003
- Di Perri, R, et. al; Journal of International Medical Research; "A multicentre trial to evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia." 1991
- Shigenaga, MK, et. al.; PNAS; "Oxidative damage and mitochondrial decay in aging;" 1994
- Na?ecz, KA, et. al.; Molecular Aspects of Medicine; "Carnitine: transport and physiological functions in the brain;" 2004
- Gibson, GE, et. al.; Biochemical Pharmacology; "Studies on the metabolic pathway of the acetyl group for acetylcholine synthesis;" 1980
- Aureli, T, et. al.; Brain Research; Aging brain: Effect of acetyl-L-carnitine treatment on rat brain energy and phospholipid metabolism. A study by 31P and 1H NMR spectroscopy;" 1990
- Angelucci, L, et. al; Journal of Neuroscience Research; "Nerve growth factor binding in aged rat central nervous system: Effect of acetyl-L-carnitine;" 1988
- Plovesan, P, et. al.; Brain Research; "Acetyl-L-carnitine treatment increases choline acetyltransferase activity and NGF levels in the CNS of adult rats following total fimbria-fornix transection;" 1994
- Precursors of acetyl groups in acetylcholine in the brain in vivo. http://www.ncbi.nlm.nih.gov/pubmed/?term=Biochim+Biophys+Acta.+1970+Jun%3B208(3)%3A538-40.
- Acetyl-L-carnitine as a precursor of acetylcholine. http://www.ncbi.nlm.nih.gov/pubmed/?term=Neurochem+Res.+1990+Jun%3B15(6)%3A597-601.
- Acetyl-L-carnitine and Alzheimer's disease: pharmacological considerations beyond the cholinergic sphere. http://www.ncbi.nlm.nih.gov/pubmed/8239306
- Is 2-dimethylaminoethanol (deanol) indeed a precursor of brain acetylcholine? A gas chromatographic evaluation. http://www.ncbi.nlm.nih.gov/pubmed/850128
- On the role of intracellular physicochemistry in quantitative gene expression during aging and the effect of centrophenoxine. A review http://www.sciencedirect.com/science/article/pii/0167494389900423
- Brain S-adenosylmethionine levels are severely decreased in Alzheimer's disease. http://www.ncbi.nlm.nih.gov/pubmed/8752143
- Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. http://www.ncbi.nlm.nih.gov/pubmed/2183633
- Choline and betaine in health and disease. http://www.ncbi.nlm.nih.gov/pubmed/20446114
- Comparison of the efficacy of inhaled budesonide and oral choline in patients with allergic rhinitis. http://www.ncbi.nlm.nih.gov/pubmed/15806211
- Zeisel, Steven; Annual Review of Nutrition; "Choline: critical role during fetal development and dietary requirements in adults;"
- Piracetam diminishes hippocampal acetylcholine levels in rats. http://www.ncbi.nlm.nih.gov/pubmed/?term=Life+Sci.+1981+Mar+9%3B28(10)%3A1091-3
- Effect of oxiracetam and piracetam on central cholinergic mechanisms and active-avoidance acquisition. http://www.ncbi.nlm.nih.gov/pubmed/3594455
- Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats. http://www.ncbi.nlm.nih.gov/pubmed/7301036
- Wurtman, RJ; Pharmacological Reviews; "Precursor control of neurotransmitter synthesis;" 1980 http://www.ncbi.nlm.nih.gov/pubmed/6115400
- Spector SA, Jackman MR, Sabounjian LA, Sakas C, Landers DM, Willis VVT. Effect of choline supplementation on fatigue in trained cyclists. Med Sci Sports Exerc 1995;27(5):669-73.
- Conlay LA, Wurtman RJ, Blusztajn JK, Covielia IJ, Maher TJ, Evoniuk GE; NEJM, "Decreased plasma choline concentrations in marathon runners;" 1986.
- The differential effects of meclofenoxate on memory loss in the elderly. http://www.ncbi.nlm.nih.gov/pubmed/329662
- Choline: an essential nutrient for public health.http://www.ncbi.nlm.nih.gov/pubmed/19906248
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Blog Post:
Keto Connect Podcast with Mike from PricePlow: Supplements for Keto | #4
Need guidance about supplements for keto dieters? Check out Mike's 2017 Keto Connect podcast interview on "Keto for Normies" with Matt & Megha! -
Oct 11, 2017 ![]()
Blog Post:
Performax Labs VasoMax: Rethinking the Pump Formula -
Oct 09, 2017 ![]()
Blog Post:
Optimizing Brain Performance with Shawn Wells | PricePlow Podcast #2
PricePlow's second podcast was one of the best we'll have, where Shawn Wells (ZoneHalo) discussed optimizing brain performance, including nootropics -
Oct 09, 2017 ![]()
YouTube Video:
Optimizing Brain Performance with Shawn Wells | Podcast #2 -
Oct 09, 2017 ![]()
Product News:
Wholesale Health Connection Alpha GPC 50% Powder was created.
Category: Alpha-GPC -
Oct 06, 2017 ![]()
Blog Post:
Northbound’s All-Natural Blend: A Stevia-Sweetened Nootropic
Stevia-based nootropic powder! Northbound Nutrition has released a new naturally-flavored / sweetened tub of their popular nootropic supplement BLEND -
Sep 29, 2017 ![]()
Blog Post:
Choline Supplements: What’s the Best Form for Focus?
Choline is an essential nutrient that provides the backbone of the learning neurotransmitter acetylcholine; learn which form is best for your needs. -
Sep 29, 2017 ![]()
Product News:
Powder City Citicoline Sodium was created.
Category: Citicoline -
Sep 29, 2017 ![]()
Product News:
SNS Choline Citrate was created.
Category: Choline Citrate -
Sep 28, 2017 ![]()
Blog Post:
iSatori Morph Xtreme Brings Energy & PUMPS to iSatori Pre Workouts!
iSatori is jumping back in the headlines after releasing their new monster pre workout Morph Xtreme that's bringing a whole lot of energy and pumps. -
Sep 27, 2017 ![]()
Blog Post:
EVL ENGN: Start Your Workout Engine at $0.80/workout!
EVL ENGN is the brand's headlining pre workout that's all about the pumps, focus, and performance. -
Sep 23, 2017 ![]()
Blog Post:
Ambrosia Mental Jewels: Daily Herbal-Driven Neuro Enhancer
Ambrosia Mental Jewels is a low stim, brain boosting nootropic supplement featuring Bacognize Bacopa Monnieri and Cordyceps, coming from Marc Lobliner -
Aug 18, 2017 ![]()
Blog Post:
AZOTH: A Fully Loaded Caffeine-Free Nootropic
AZOTH is a fully-loaded nootropic supplement developed to increase your motivation, focus, energy, and productivity. -
Aug 05, 2017 ![]()
Blog Post:
Lumonol Nootropic: A Popular Memory Supplement But…
Lumonol is a popular nootropic supplement that may be great for memory, but can we build a better one for cheaper? We analyze the Lumonol Ingredients. -
Jul 27, 2017 ![]()
Blog Post:
The Ape SH*T Pre Workout — Go APE on the Weights!
The Ape Shit pre workout is aptly named - from new company Untamed Labs that will have you going Ape next time you step in the gym! -
Jul 21, 2017 ![]()
Blog Post:
TruBrain Bars — Nootropic powered Energy Snack!
TruBrain is the first of its kind all natural energy / snack bar loaded with nootropics like Citicoline! -
Jul 20, 2017 ![]()
Blog Post:
NTel Pharma Clenadrol X: Powerful All-in-One Fat Burner
Clenadol X is a true powerhouse fat burner from NTel Pharma that's packing DMHA AND Ephedra alongside thyroid boosters! Well rounded fat burner! -
Jul 14, 2017 ![]()
Blog Post:
MAN Sports Brain Bridge: Powdered Brain Power!
Brain Bridge is powerful nootropic supplement from MAN Sports to enhance cognition, focus, and productivity. -
Jul 06, 2017 ![]()
Blog Post:
Mind Muscle Nutrition Hydra Focus: Intra Keeps Your Concentration
MInd Muscle Nutrition Hydra Focus is a novel spin on the conventional intra workout that enhances pumps and focus alongside hydration and performance. -
Jun 24, 2017 ![]()
Blog Post:
Onnit Alpha Brain – Overrated Cognitive Booster for Beginners?
Onnit Alpha Brain is an incredibly popular nootropic touted by celebrities around the world, but is it really just an over-hyped, overpriced product? -
Jun 09, 2017 ![]()
Blog Post:
Modafinil (Provigil) – The Superstar Wakefulness Pill
Modafinil is one of the most popular and powerful wakefulness agents used as a nootropic drug. We dig into this "Limitless" style pill! -
Jun 07, 2017 ![]()
YouTube Video:
VMI Sports K-XR Review: Take the Miami Vice! -
Jun 01, 2017 ![]()
Blog Post:
Apollon Nutrition Hooligan – 600mg Caffeine Pre Workout!!! -
May 05, 2017 ![]()
Blog Post:
MPA Supps CelluVOL – Matt Porter’s Personal Pre Workout!
MPA Supplements CelluVOL is the clinically dosed stimulant free pre workout developed by Matt Porter. -
Mar 22, 2017 ![]()
Blog Post:
MaxQ Nutrition’s Maxed Out Pre Workout – The Fattest Pre EVER?
MaxQ Nutrition has crafted a true world beater in their Maxed Out Pre Workout which contains everything you'd want to have a Maxed Out workout! -
Mar 17, 2017 ![]()
Blog Post:
DVST8 CRIMSON Pre Workout: Inspired Gets Streamlined
Inspired Nutraceuticals has released a follow up to their popular White Cut pre workout with a more streamlined economical version in DVST8 Crimson. -
Mar 08, 2017 ![]()
Blog Post:
Genius PRE Workout: Train Smarter AND Harder
Genius Pre is a clinically dosed, stimulant free pre workout that enhances focus but won't leave you feeling bottomed out from a rush of caffeine. -
Mar 06, 2017 ![]()
Blog Post:
Performax Labs NootropiMax – Free Your Mind
Performax Labs enters the nootropics market with NootropiMax, a powerful focus and cognitive boosting supplements. Free Your Mind with NootropiMax! -
Feb 23, 2017 ![]()
Blog Post:
Ghost Legend – A Pre-Workout Fit for Legends
Ghost has reformulated their headlining pre workout Ghost LEGEND -- it's now 100% transparent and significantly more powerful. -
Feb 07, 2017 ![]()
Blog Post:
Blackstone Labs Hype Extreme: Long-Lasting Pumps & Focus
Hype Extreme is a brand new stimulant free pre workout from Blackstone labs that significantly enhances pumps and focus. -
Jan 20, 2017 ![]()
Blog Post:
ATP Nutrition Perform Kinetics: The Perfect Surprise Pre Workout
ATP Nutrition has crafted the ultimate performance enhancing pre workout in Perform Kinetics, and we LOVE it! Why? High-dose TeaCrine! -
Jan 19, 2017 ![]()
Blog Post:
VMI Sports K-XR: High Energy High-Stim Pre Workout
K-XR is the all new high energy, strength boosting pre workout from VMI Sports that is generating quite a buzz in the industry. -
Jan 12, 2017 ![]()
Blog Post:
Primeval Labs Gray Matter – Serious Brain Gains
Primeval Labs Gray Matter is the first nootropic supplement for serious brain gains. The doses look good, but it will come down to caffeine:theanine! -
Jan 04, 2017 ![]()
Blog Post:
HAKNutrition PreHAK – The Ultimate Workout Hack!
HAKNutrition is a new supplement company with PreHAK, an incredibly well dosed pre workout supplement that makes the perfect "hack" for your workout! -
Dec 28, 2016 ![]()
Blog Post:
Repp Sports ReactR: Go Nuclear on your Workouts!
Repp Sports is a brand new supplement company that recently burst onto the scene with their DMHA powered pre workout ReactR. -
Dec 28, 2016 ![]()
Blog Post:
Sidewalk Kraka: CT Fletcher’s Pre Workout by Iron Addicts!
Sidewalk Kraka is CT Fletcher's new pre workout supplement from his brand, Iron Addicts. It has 300mg caffeine, DMHA, Eria Jarenesis, and more! -
Dec 14, 2016 ![]()
Blog Post:
Controlled Labs GAMER UP – Leveling Up Made Easy!
Controlled Labs GAMER UP is a new gaming supplement that brings a serious dose of focus agents, but not too much caffeine. No more gaming jitters! -
Dec 13, 2016 ![]()
Blog Post:
C4 Ultimate: Cellucor’s Pinnacle Pre Workout!
Cellucor C4 Ultimate is the *ultimate* pre workout experience from Cellucor that features a mostly transparent label and well-dosed pump ingredients. -
Dec 07, 2016 ![]()
Blog Post:
PES Prolific – PEScience is Back in the Pre Workout game!
PES Prolific brings PEScience back into the stimulant pre workout market - it's a performance and focus centric pre workout for the intelligent lifter -
Nov 28, 2016 ![]()
Blog Post:
PWO-MAX: Prime Nutrition’s MONSTER Reformulation
PWO-MAX is returning to greatness - the first Prime re-release is a charged up version of its pre workout PWO-MAX, with DMAA and sodium nitrate! -
Nov 26, 2016 ![]()
Blog Post:
Jim Stoppani Sued AGAIN. New Class Action Lawsuit
Jim Stoppani has been sued AGAIN. This time, a class action lawsuit was filed in California regarding the ingredient-based claims made by Stoppani. -
Nov 10, 2016 ![]()
Blog Post:
Phenylpiracetam: The Limitless Nootropic
Phenylpiracetam is a brain-enhancing nootropic also known as Phenotropil and Carphedon, similar to piracetam but with an added kick for motivation! -
Nov 07, 2016 ![]()
Blog Post:
InnovaPharm LIMITLESS: Unlock Your Mind’s Muscle!
InnovaPharm's Limitless is a focus-fueled pre workout supplement that packages phenylpiracetam, DMHA, and other goodies for a potent combination. -
Oct 29, 2016 ![]()
Blog Post:
Muscle Research Pump Juice Extreme: The Mid-Aged Man’s Pre
Muscle Research Pump Juice Extreme is a pre workout supplement with an assortment of energy and pump ingredients for a well-rounded workout! -
Oct 12, 2016 ![]()
Blog Post:
RedCon1 Mental Trigger Brings the BRAIN Gains
RedCon1 Mental Trigger: Gamers and "spreadsheet athletes" listen up, the ultimate BRAIN gains supplement is here, and it's your new Mental Trigger. -
Oct 07, 2016 ![]()
Blog Post:
Blue Star Elevate: Maximum Mental Muscle Potential!
Blue Star Elevate is an incredibly well crafted nootropic-based supplement that enhanced focus, mood, cognition, and drive. -
Oct 04, 2016 ![]()
Blog Post:
Meet the Man Who REALLY Formulated Pre-JYM
Jim Stoppani claims that he formulated Pre-JYM. But do the latest court documents in the lawsuit against them corroborate that? Find out at PricePlow. -
Sep 28, 2016 ![]()
Blog Post:
ANS RAVE: Energy For Lifters, Gamers, and Hard Workers!
ANS Performance RAVE is the new mental productivity supplement with an extremely unique, and well-dosed ingredient list including Lion's Mane & DMHA! -
Sep 21, 2016 ![]()
Blog Post:
Divided Labs PREVIDE: Serious Pre-Workout.. but at 2 Scoops
Divided Labs PREVIDE is a fantastic-looking pre workout supplement... but at two scoops. The question is, will that be worth it then? PricePlow digs. -
Sep 13, 2016 ![]()
Blog Post:
Alpha One Labs Obliter8: No-Joke Fat Burning Powder
AlphaOne Labs have created one of the most intense fat burning powders around in Obliter8 that packs lots of energy and mood elevating ingredients. -
Sep 06, 2016 ![]()
Blog Post:
Northbound Nutrition BLEND – Cognitive Energy & Endurance
Blend from Northbound Nutrition is a clinically dosed cognition enhancing supplement perfect for work or working out. Maybe even a gaming supplement! -
Aug 25, 2016 ![]()
Blog Post:
MOD Gaming Supplement – Amp up your Gaming Focus!
The MOD Gaming Supplement is a very well-dosed, focus-based supplement for eSports gamers that provides some energy, but more smooth, controlled focus -
Aug 12, 2016 ![]()
Blog Post:
PlasmaJet is Back! Gaspari’s Return Continues (w/ Review)
PlasmaJet. Is. Back! Gaspari Nutrition's epic return continues with the release of a revamped PlasmaJet Nitric Oxide Maximizer, and it's way different -
Aug 09, 2016 ![]()
Blog Post:
Northbound Nutrition PINNACLE: The Pinnacle of Pre Workouts?
The Pinnacle Pre Workout from Northbound Nutrition is a premium pre workout supplement that combines clinical and transparently dosed ingredients! -
Aug 08, 2016 ![]()
Blog Post:
RedCon1 Big Noise: Focused Bunker Busting Pump-Bombs!
RedCon1 Big Noise is a stimulant-free pre workout supplement that will keep you FOCUSED even without the stimulants: The highest level of readiness! -
Jul 22, 2016 ![]()
Blog Post:
First Finisher Champion Performance Powder: Gains for Miles
First Finisher is a new supplement company whose mission is to create CHAMPIONS. Their stim-free pre workout Champion Performance Powder will do just that! -
Jul 13, 2016 ![]()
Blog Post:
Performance Inspired: Mark Wahlberg’s New Supplement Brand
Performance Inspired is Mark Wahlberg's new supplement brand! The A-List celebrity and fitness aficionado, Marky Mark, is ready to take on the beast! -
Jul 01, 2016 ![]()
Blog Post:
Ronnie Coleman Yeah Buddy Pre Workout: Extreme Stimulants!
Ronnie Coleman YEAH BUDDY is a new super high-stim pre workout called but doesn't have much in terms of pumps or muscle-builders / ergogenics. -
Jun 20, 2016 ![]()
Blog Post:
Proccor Ultra Octane – Pumps, Performance, and Recovery
Proccor's Ultra Octane is a new stimulant free pre workout that packs in everything needed for enhanced performance, pumps, and recovery. -
Jun 09, 2016 ![]()
Blog Post:
Alphamine Reformulated for Better Feels: The Sexiest Supplement
Alphamine is a fat burning energy drink powder by PES, or PEScience. We think it's the sexiest, best supplement out there. Read why on PricePlow! -
Jun 06, 2016 ![]()
Blog Post:
BZERQ by AlphaOne Labs: Focused Pre Workout Down Under
BZERQ by Alpha One Labs is a new focus-based pre workout supplement in Australia that has a serious new stimulant Ozzies and Kiwis must try! -
May 20, 2016 ![]()
Blog Post:
Transparent Labs PreSeries STIM-FREE: Naturally Heavy Pumps
Transparent Labs PreSeries STIM-FREE is a comprehensive pre workout that offers pumps, focus, endurance, and power all without the use of stimulants. -
May 10, 2016 ![]()
Blog Post:
BPI Best PRE Workout – A Keto Diet Pre Workout?
BPI Sports has a new keto-targeted product tilted Best Pre Workout, using the keto-inducing power of BHB to help you burn fat for fuel during workouts -
Apr 26, 2016 ![]()
Blog Post:
Momentum Nutrition Formula 56: High-Powered Fat Burner
Formula 56: Momentum Nutrition has just released their 3rd supplement, a transparently dosed fat burner to help with the summer cut. -
Apr 15, 2016 ![]()
Blog Post:
Proccor Pre-RX – Workout Enhancement for Focused Athletes
Proccor has upgraded their monster pre workout Pre-Rx and it's the perfect prescription for your workout. -
Apr 13, 2016 ![]()
Blog Post:
Pumped Sports Loaded – A Solid Pre from Far Away
Pumped Sports is an up and coming New Zealand supplement brand with big things! Loaded is a comprehensive pre workout that is packed with goodies. -
Mar 28, 2016 ![]()
Blog Post:
Olympus Labs ELIX1R of the Gods & Goddesses
Olympus Labs ELIX1R is a focus and energy supplement that's great for everyone from the gym to the gamers. Everything we could ask for all in one! -
Mar 28, 2016 ![]()
Blog Post:
Komodo Katana v4 – A Sharper Sword w/ Moderate Stims
Komodo Katana v4 is out, and it's a pre workout supplement that perfectly balances energy, focus, pumps, and endurance for low/moderate stim users! -
Mar 16, 2016 ![]()
Blog Post:
Hemavo2 MAX Upgraded (2016)! Get Your Guns Ready!
The King of Pumps is back! iForce Nutrition has reformulated Hemavo2 Max to include a whopping dose of HydroMax and Nitrates. -
Mar 02, 2016 ![]()
Blog Post:
Magnum Carne Diem – Seize the Fat Loss!
Carne Diem is the newest non stimulant fat burner from Magnum Nutraceuticals that puts a truly unique spin on carnitine supplements. -
Feb 08, 2016 ![]()
Blog Post:
Magnum Rocket Science – Research-Backed Energy Capsule
Rocket Science from Magnum Nutraceuticals is a research-backed capsule based pre workout that increases energy, focus, and alertness. -
Jan 14, 2016 ![]()
Blog Post:
PreSeries BULK – $49 Pre Workout Has Industry Abuzz…
Transparent Labs PreSeries Bulk is a serious pre workout, with efficacious doses of everything you'd want in a pre workout. But is it worth $49?! -
Jan 06, 2016 ![]()
Blog Post:
Alpha GPC for Strength CONFIRMED: 600mg/day for Legs!
Alpha-GPC for strength CONFIRMED! A new study found that 600mg daily of Alpha GPC significantly improves leg strength, and possibly more! -
Dec 29, 2015 ![]()
Blog Post:
Olympus Labs TR1UMPH: Next-Gen Muscle Builder
Olympus Labs TR1UMPH is an all new formulation muscle-builder that's retooled to be all natural for gains and recovery, based on phosphatidic acid! -
Dec 22, 2015 ![]()
Blog Post:
ANS Diablo Inferno: Seriously Thermogenic Fat Burner
Diablo Inferno is the all new high-powered thermogenic fat burner from ANS that's rumored to be as potent as 2 scoops of the powder! -
Dec 17, 2015 ![]()
Blog Post:
Rich Piana’s 5150 Pre Workout: Involuntary Psychiatric Hold
5150 is a high stim pre workout from Rich Piana and 5% Nutrition specifically made for those that regularly need 2 to 3 scoops of "standard" pre workouts. -
Dec 02, 2015 ![]()
Blog Post:
Conqu3r Unleashed by Olympus Labs: Balanced Perfection
Olympus Labs Conqu3r Unleashed has hit the market! Get the full scoop on just what's inside this super balanced high-powered pre workout supplement -
Nov 25, 2015 ![]()
Blog Post:
Nitramine 2015: Myokem’s Reformulation for MORE Focus
Myokem Nitramine has been updated as the popular focus pre workout removes picamilon in favor of L-Theanine and Theacrine, and adds ALCAR over LCLT. -
Nov 24, 2015 ![]()
Blog Post:
Modern PRE: The Next Generation USPLabs Pre Workout
Modern PRE is the new USPLabs pre workout supplement that's slated for late 2015 / early 2016. Rumor has it that it will be LOADED! -
Nov 23, 2015 ![]()
Blog Post:
Rich Piana’s MENTALITY – Cognitive Booster Leaves *Nothing* Out
Rich Piana's Mentality is a cognition boosting supplement that contains virtually every nootropic and amino acid to elevate memory and mental function. -
Nov 04, 2015 ![]()
Blog Post:
Best Sleep Aid Guide: Supplements, Ingredients, & Herbs
What's the Best Sleep Aid? It depends if you want a full-blown sleep aid supplement, or just a single-ingredient herb or compound. We cover it all! -
Nov 02, 2015 ![]()
Blog Post:
Olympus Labs Conqu3r Unleashed Stim-Free: Loaded to the Gills!
Conqu3r Unleashed Stim-Free is the Olympus Labs caffeine-free pre workout unveiled with 5 patented ingredients all clinically dosed. -
Oct 21, 2015 ![]()
Blog Post:
C4 Neuro – Cellucor’s C4 with FOCUS
C4 Neuro is the latest incarnation of Cellucor's pre workout that packs a lot of the things you love about the standard plus of a potent nootropic blend. -
Oct 01, 2015 ![]()
Blog Post:
Carbon PREP – Layne Norton’s Pre Workout DOA
Carbon Prep is Layne Norton's debut nearly-stim-free pre workout for his brand new supplement line, Carbon. Let's see what's in store (it's LOADED!) -
Sep 23, 2015 ![]()
Blog Post:
MuscleSport Rhino Black – High Energy & Pump Pre Workout
Rhino Black is the newest high energy, pump-centric workout from MuscleSport specifically tailored to give razor focus and skin-splitting pumps! -
Sep 08, 2015 ![]()
Blog Post:
CT Fletcher’s Pre Workout ISYMFS by iSatori Analyzed
CT Fletcher's pre workout supplement, ISYMFS, is finally here from the YouTube fitness star and iSatori! Will it make you an "IRON ADDICT"? -
Aug 11, 2015 ![]()
Blog Post:
OxySport Black: MusclePharm’s Fat Burning Goes to the Dark Side
OxySport Black is the latest fat burner from Musclepharm as part of their GNC-exclusive Black Line of products that boasts focus, energy, and fat burning. -
Aug 04, 2015 ![]()
Blog Post:
BPI Burn XS – Stim-Free Focus Fat Burner
BPI Burn XS is the newest one-pill weight loss solution from BPI that promises "mind bending clarity" in addition to weight loss, but no stimulants -
Jul 18, 2015 ![]()
Blog Post:
Athletic Edge Steel Edge – Sharpening the Pre Workout Game
Athletic Edge Steel Edge is the new AEN pre workout. A high stim, focus-heavy pre designed to sharpen all aspects of your fitness pursuits!. -
Jun 09, 2015 ![]()
Blog Post:
Noopept Mega Guide: Enhancing the Smart Within
Noopept is a nootropic (cognitive brain enhancer) that's gaining huge popularity. We discuss the best noopept benefits, dosage, and side effects here -
May 27, 2015 ![]()
Blog Post:
Magnum Limitless: New Pre-Workout Focusing on FOCUS
Magnum Limitless is the new pre workout supplement coming in June. We don't know much about the Limitless ingredients yet, but we're guessing FOCUS! -
May 15, 2015 ![]()
Blog Post:
SP250 – Gaspari’s Unique New Pre Workout for 2015
SP250 is Gaspari Nutrition's much anticipated new pre workout supplement, with some completely new ingredients. We analyze the new SP 250 review! -
Apr 30, 2015 ![]()
Blog Post:
Altius Pre Workout Review (Jacked Factory)
ALTISU PricePlow is back with a full in-depth review of Jacked Factory's fantastic pre-workout, Altius. -
Apr 29, 2015 ![]()
Blog Post:
Controlled Labs White Rapids – Feel the Rush!
Controlled Labs White Rapids is a new pre workout supplement meant to replace the White Flood franchise. The ingredient label is open and looks great! -
Apr 03, 2015 ![]()
Blog Post:
ONWARD: Flag Nor Fail’s Unique Health Supplement
The ONWARD Supplement is a new daily immune/energy/focus/mood booster from Flag Nor Fail's Rob and Dana Linn Bailey. But is it worth the price? -
Mar 31, 2015 ![]()
Blog Post:
Altius Pre-Workout by Jacked Factory: The G.O.A.T?!
The Altius Pre Workout by Jacked Factory is an Amazon product that is absolutely LOADED and has tons of great reviews. We analyze the ingredients. -
Feb 12, 2015 ![]()
Blog Post:
SAN MegaTron – Stim-Free Supplement as Good as its Name
SAN MegaTron is a stimulant-free pre workout supplement that has exciting doses of both nitric oxide boosters AND focus enhancers. And what a name! -
Jan 29, 2015 ![]()
Blog Post:
PES ERGONINE – It’s About Time Someone Made This!
Athletix Ergonine has been touted as a once-daily muscle builder that covers all of your bases for less than a dollar per day. Does it add up? (YES!) -
Jan 17, 2015 ![]()
Blog Post:
Amino HP – ANS Performance’s Fully-Loaded BCAA Powder
Amino HP is ANS Performance's answer to all of the BCAA supplements and intra workouts out there. It's fully loaded and knowing ANS, will taste great -
Apr 12, 2014 ![]()
Blog Post:
CRAZE v2 by Driven Sports is Out! Feeling Risky Today?
Is Craze 2.0 on its way? Rumors are swirling about a new Driven Sports Craze formula. This is the pre workout supplement that did the unthinkable.
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Choline Price Alerts
The following price alerts are still active:
- Aug 20, 2019SNS Choline Citrate 500 Grams dropped by 11.2% to $7.96 at DPS Nutrition
- Jul 17, 2019PrimaForce Choline Bitartrate 250 Grams dropped by 22.9% to $87.34 at Amazon
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Choline Reviews & YouTube Videos
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Aug 19, 2019CEO Level Nootropic | Cutler Cognition Review
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Mar 23, 2019NutraBio Alpha EAA Strawberry Lemon BOMB!
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Feb 15, 2019NutraBio Alpha EAA: Essential Amino Acids + Nootropics!
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Dec 04, 2018Primeval Labs Mega Pre BLACK Review
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Nov 30, 2018BEST Nootropic Energy Drink | SNS Focus XT Review
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Oct 22, 2018SNS Focus XT Nootropic | CANDY CORN Flavored Supplement Review!
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Sep 10, 2018VMI Sports K-XR Pre Workout Flavor Review (Geographical Flavors?!)
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Aug 20, 2018Performax Labs StimMax Review - HIGH Stim Pre Workout Energy, New Flavors!
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Aug 14, 2018Best Nootropic Stack for Beginners: Expert Shawn Wells Weighs In
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Jul 30, 2018Performax Labs FitMax Review | Next-Level Fat Burning Drink
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Mar 14, 2018Sparta Nutrition CogniKeto Review: Nootropic for Keto Dieters!
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Oct 09, 2017Optimizing Brain Performance with Shawn Wells | Podcast #2
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Jun 07, 2017VMI Sports K-XR Review: Take the Miami Vice!
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