An essential nutrient required for a myriad of functions, choline should be part of a well-rounded diet. Studies indicate that only about 10% of Americans consume enough dietary choline.[39]
Additionally, endurance athletes, and people who regularly consume alcohol, are at risk of choline deficiency. Now is an important time to admit that you're probably among the looming majority of choline neglectors.
Benefits
Brain
Choline is classified as an essential nutrient. While it can be synthesized within the body, we only produce insufficient amounts -- and doing so compromises the structural integrity of our cells. Phosphatidylcholine helps to compose the lipid membrane of cells, and when enough free choline isn't available, your body breaks this structure down to obtain the compound.
This is an interesting and vicious example of biological self-immolation -- a process that favors short-term performance at the behest of compromised long-term health. Supplementing choline into your diet may circumnavigate this issue. In other words, you can have your cake and eat it too. Below are a few benefits:
-
Improved global cognitive function
Choline is a precursor to the neurotransmitter acetylcholine, which is implicated in memory, intelligence, and mood. Animal studies suggest that high choline intake protects the brain's ability to form and recall memories despite the progression of age. In particular, "choline-supplemented older mice performed as well as young three-month-old mice."[31] The supplemented mice were also observed to have increased communication within the hippocampus.
-
Heart health and depression
Dietary choline is an essential source of methyl groups for many biological processes. For example, one metabolite of choline is trimethylglycine, or betaine (an ingredient in many pre-workout formulations), which participates in the production of SAM-e. Deficits of SAM-e are implicated in Alzheimer's disease, diabetes, heart disease, depression, and more.[27,28,29]
-
Anti-inflammatory
Higher dietary intake of choline is associated with lower inflammatory markers, and reduced symptoms of allergic rhinitis.[30]
Body
Acetylcholine is the most abundant neurotransmitter in the entire body, responsible for muscle contractions. "Consumption of supplemental choline can also increase the release of acetylcholine from nerve endings, including those that cause skeletal muscle to contract," according to a study published in Pharmalogical Reviews.[35]
Intense exercise
Unsurprisingly, intensive exercise results in a significant reduction in plasma choline levels, particularly prolonged and strenuous activity. After two hours of exercise, participants lost about 40% to 50% of free choline.
The good news is that ingesting choline pre-exercise can not only prevent this loss, but raise it above baseline for up to two hours post-exercise (2g of free choline was used in this study).[36]
In one study, individual performance was enhanced after choline supplementation compared to when the same individuals consumed a placebo.[37]
Choline sources
Many different choline formulations are available. There is a huge price disparity between certain supplements. Some are very cheap and others comparatively expensive. Naturally, you would want potency to increase along with price -- which the expensive ones certainly do -- but the real advantage of CDP-choline (expensive) over something like choline citrate (cheap) is its fanciness.
Choline Molecule
All choline precursors follow the same protocol: choline bound with some other chemical. For the cheap supplements, the choline is bound to another relatively inactive compound, so you're essentially getting just choline. But the expensive acetylcholine precursors consist of choline bound with other biologically active compounds that enhance absorption or produce other reactions that work to multiply choline's effects. Below is a list of the most common formulations. Each has its own particular benefits and detractions.
Choline bitartrate and choline citrate
These two are thrown together because they are so similar in the most important respects. Simple choline salts are cheap as dirt, but have questionable potency. Users have complained of stomach aches because of the amount consumed for desired effects, but you get what you pay for.
You may ask why these compounds are not very potent. Technically free choline, due to its polarity, would not be able to cross the blood-brain barrier. While we have a choline transport system, it's sadly inefficient and seems to decline with age.
CDP-choline
Hands down, this is the best choline source available. Multitudes of animal research and fair amounts of human research attest to the efficacy of CDP-choline, or citicoline.
Human studies have shown neuro-protective and neuro-regenerative effects
and a proven efficacy for improving the following conditions:
-
Alzheimer's disease
-
Parkinson's disease
-
Age-related memory and learning deficits
-
Stroke
-
Drug addiction
-
Glaucoma-induced ocular damage
-
Traumatic brain injury
-
Schizophrenia
CDP-choline is more expensive than bitartrate and citrate, but generally cheaper than alpha-GPC.
Alpha-GPC
A natural choline compound already swimming around your brain and derived from soy lecithin, this is probably the most bioavailable choline source, but also the most expensive. You should expect similar effects as you would with citicoline. One study found alpha-GPC more effective than citicoline for vascular dementia[15], with another showing higher plasma choline levels after alpha administration over CDP.
As you can see, alpha-GPC and CDP-choline are the two rock stars of acetylcholine precursors. Some studies suggest GPC is better, but there is just so much more research attesting to the efficacy of CDP-choline.
Other enhancers
Choline metabolism
You may notice by now that you need an acetyl to go with that lonely choline for magic to happen. That is absolutely true, and a great addition to a basic choline stack is ALCAR, or acetylcarnitine.
ALCAR
Acetyl L-carnitine is great stuff -- no argument. It's naturally produced in your body during strenuous exercise, and supplementation has dramatic effects, irrespective of its role in energy production.
-
By donating the acetyl group, ALCAR enhances acetylcholine production.
-
Both ALCAR and L-carnitine stimulate muscle production.
-
It stimulates nerve growth factor release.
-
Improves neuronal membrane fluidity (more communication).
-
Acetylcholine receptor agonist.
-
Increases the utilization of glucose, ketone bodies, and lipid substrates in the brain.
-
Improves choline uptake (thus acetylcholine synthesis).[21]
Aside from the pro-cognitive effects, ALCAR may have overall lifespan enhancing effects. Simply put, our mitochondria (powerhouse of cells) have to put up with decades of abuse, and they produce toxic reactive oxygen species (ROS), or free radicals. A damaged mitochondrion is leaky and our current understanding of the aging process points many fingers toward this compromised structure. "Acetyl-L-carnitine, a high-energy mitochondrial substrate, appears to reverse many age-associated deficits in cellular function."[16]
DMAE
This compound is frequently cited as a choline precursor, but it probably has little if anything to do with acetylcholine production.[25] Rather, DMAE seems to bind with phospholipids that compose cellular membranes. Where phosphatidylcholine would be, phosphatidyl-dimethylaminoethanol now takes its place, increasing membrane permeability and antioxidant capacity.[26]
Centrophenoxine
Also known as meclofenoxate, this is basically supercharged DMAE (specifically an ester of DMAE). Though limited evidence suggests mental stimulation and memory improvement, it has beneficial phospholipid properties with little direct effects on choline or acetylcholine.
Racetams
Bacon and eggs
If you are taking any of the racetam derivatives, then you probably know that the cholinergic system is involved with their effects. Many people believe this means your brain on piracetam, for example, will consume more choline than otherwise. Two studies, conducted on rats, assert that piracetam and oxiracetam reduces hippocampal acetylcholine levels.[32,33] Regardless, other animal studies suggest a synergistic effect with racetams and a choline source.[34] For many, choline and piracetam is like bacon and eggs -- it just feels right for them to keep each other company.
Consider Noopept
Although it's not technically a "racetam", Noopept is structurally very similar, and yields a piracetam-like effect, but many think it's even better.
It stacks incredibly well with choline -- you can read more on the Noopept blog post linked just above.
Choline intake
According to the Institute of Medicine, the adequate intake (AI) of choline is 425mg/day for women and 550mg/day for men. As a reference, any of the choline salts (bitartrate, citrate) are about 41% free choline. So something over 1000mg should satisfy your minimum daily requirements.
Remember that choline is present in many foods, most prominently in beef, beef liver, and eggs.
Hands down, CDP choline (citicoline) is the best choline source available.
It's difficult to determine what the optimal dose would be for cognitive function. The cholinergic system is tricky, and everyone is different. With that said, the most common dose for all choline precursors falls somewhere between 250mg to 2000mg.
None of these statements constitute medical advice. These supplements are not regulated or approved by the FDA. You should consult a medical doctor before embarking on self-treatment.
Side effects
The side effects of choline supplementation seem few, mild, and transient. As mentioned above, people occasionally complain of stomach discomfort. If you happen to have the rare genetic disorder, trimethylaminuria, consuming too much choline will make your body exude the odor of overripe fish.
References
- Alvarez, XA; Methods and Findings in Experimental and Clinical Pharmacology; "Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity and cerebral perfusion;" 1999
- Secades, JJ; Methods and Findings in Experimental and Clinical Pharmacology; "CDP-choline: pharmacological and clinical review;" 1995
- Marti Masso, JF; Clinical Therapeutics; "Citicoline in the treatment of Parkinson's disease;" 1991
- Cubells, JM; Clinical Therapeutics; "Clinical trial on the use of cytidine diphosphate choline in Parkinson's disease;" 1988
- Babb, SM, et. al.; Psychopharmacology; "Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study;" 2002
- Antoni D?valos, MD, et. al.; American Heart Association; "Oral Citicoline in Acute Ischemic Stroke An Individual Patient Data Pooling Analysis of Clinical Trials;" 2002
- Lukas, SE, et. al; Psychopharmacology; "Effects of short-term citicoline treatment on acute cocaine intoxication and cardiovascular effects;" 2001
- Renshaw, PF, et. al.; Psychopharmacology; "Decreased activity of brain phospholipid metabolic enzymes in human users of cocaine and methamphetamine;" 1999
- Renshaw, PF, et. al.; Psychopharmacology; "Short-term treatment with citicoline (CDP-choline) attenuates some measures of craving in cocaine-dependent subjects: a preliminary report;" 1999
- Parisi, V, et. al.; Progress in Brain Research; "Evidence of the neuroprotective role of citicoline in glaucoma atients;" 2008
- Secades, JJ, et. al.; Methods and Findings in Experimental and Clinical Pharmacology; "CDP-choline: pharmacological and clinical review;" 1995
- Zafonte, R.; Journal of Neurotrauma; "The citicoline brain injury treatment (COBRIT) trial: Design and methods;" 2009
- Deutsch, SI, et. al.; Clinical Neuropharmacology; "First administration of cytidine diphosphocholine and galantamine in schizophrenia: A sustained alpha7 nicotinic agonist strategy;" 2008
- De Jesus Moreno Moreno, M; Clinical Therapeutics; "Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: A multicenter, double-blind, randomized, placebo-controlled trial;" 2003
- Di Perri, R, et. al; Journal of International Medical Research; "A multicentre trial to evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia." 1991
- Shigenaga, MK, et. al.; PNAS; "Oxidative damage and mitochondrial decay in aging;" 1994
- Na?ecz, KA, et. al.; Molecular Aspects of Medicine; "Carnitine: transport and physiological functions in the brain;" 2004
- Gibson, GE, et. al.; Biochemical Pharmacology; "Studies on the metabolic pathway of the acetyl group for acetylcholine synthesis;" 1980
- Aureli, T, et. al.; Brain Research; Aging brain: Effect of acetyl-L-carnitine treatment on rat brain energy and phospholipid metabolism. A study by 31P and 1H NMR spectroscopy;" 1990
- Angelucci, L, et. al; Journal of Neuroscience Research; "Nerve growth factor binding in aged rat central nervous system: Effect of acetyl-L-carnitine;" 1988
- Plovesan, P, et. al.; Brain Research; "Acetyl-L-carnitine treatment increases choline acetyltransferase activity and NGF levels in the CNS of adult rats following total fimbria-fornix transection;" 1994
- Precursors of acetyl groups in acetylcholine in the brain in vivo. http://www.ncbi.nlm.nih.gov/pubmed/?term=Biochim+Biophys+Acta.+1970+Jun%3B208(3)%3A538-40.
- Acetyl-L-carnitine as a precursor of acetylcholine. http://www.ncbi.nlm.nih.gov/pubmed/?term=Neurochem+Res.+1990+Jun%3B15(6)%3A597-601.
- Acetyl-L-carnitine and Alzheimer's disease: pharmacological considerations beyond the cholinergic sphere. http://www.ncbi.nlm.nih.gov/pubmed/8239306
- Is 2-dimethylaminoethanol (deanol) indeed a precursor of brain acetylcholine? A gas chromatographic evaluation. http://www.ncbi.nlm.nih.gov/pubmed/850128
- On the role of intracellular physicochemistry in quantitative gene expression during aging and the effect of centrophenoxine. A review http://www.sciencedirect.com/science/article/pii/0167494389900423
- Brain S-adenosylmethionine levels are severely decreased in Alzheimer's disease. http://www.ncbi.nlm.nih.gov/pubmed/8752143
- Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. http://www.ncbi.nlm.nih.gov/pubmed/2183633
- Choline and betaine in health and disease. http://www.ncbi.nlm.nih.gov/pubmed/20446114
- Comparison of the efficacy of inhaled budesonide and oral choline in patients with allergic rhinitis. http://www.ncbi.nlm.nih.gov/pubmed/15806211
- Zeisel, Steven; Annual Review of Nutrition; "Choline: critical role during fetal development and dietary requirements in adults;"
- Piracetam diminishes hippocampal acetylcholine levels in rats. http://www.ncbi.nlm.nih.gov/pubmed/?term=Life+Sci.+1981+Mar+9%3B28(10)%3A1091-3
- Effect of oxiracetam and piracetam on central cholinergic mechanisms and active-avoidance acquisition. http://www.ncbi.nlm.nih.gov/pubmed/3594455
- Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats. http://www.ncbi.nlm.nih.gov/pubmed/7301036
- Wurtman, RJ; Pharmacological Reviews; "Precursor control of neurotransmitter synthesis;" 1980 http://www.ncbi.nlm.nih.gov/pubmed/6115400
- Spector SA, Jackman MR, Sabounjian LA, Sakas C, Landers DM, Willis VVT. Effect of choline supplementation on fatigue in trained cyclists. Med Sci Sports Exerc 1995;27(5):669-73.
- Conlay LA, Wurtman RJ, Blusztajn JK, Covielia IJ, Maher TJ, Evoniuk GE; NEJM, "Decreased plasma choline concentrations in marathon runners;" 1986.
- The differential effects of meclofenoxate on memory loss in the elderly. http://www.ncbi.nlm.nih.gov/pubmed/329662
- Choline: an essential nutrient for public health.http://www.ncbi.nlm.nih.gov/pubmed/19906248
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NutraBio's PRE Workout, named PRE, was recently upgraded, and now more than ever it's our #1 pre workout with no 'exotic' stimulants and no carbs! -
Jan 25, 2018 ![]()
Blog Post
NTel Pharma Lipo-H4ck: Hack Your Way to Fat-Loss
NTel Nutra Lipo-H4ck is the high-powered, feel good fat burner that replaces Clenadrol X. Lipo H4ack's loaded with PEA, including lotus leaf extract -
Jan 19, 2018 ![]()
Blog Post
Controlled Labs Orange Brainwash – Supreme Cognitive Booster
Controlled Labs explodes back on the scene with a powerhouse nootropic supplement titled Orange Brain Wash, and it has nearly EVERY nootropic we love! -
Jan 18, 2018 ![]()
Blog Post
Apollon’s Hooligan Bare Knuckle: Attack the Gym Stim-Free
Hard-hitting brand Apollon Nutrition is back with a stim free version of their 600mg caffeine pre workout with Hooligan Bare Knuckle. -
Jan 17, 2018 ![]()
Blog Post
NTel Pharma AREZ Mega-Update: When Two Gods Collide!
NTel Pharma looks to dominate the pre workout market in 2018 with the release of Mega-AREZ, the pre workout that smashes TWO Gods of the Gym in one. -
Jan 15, 2018 ![]()
Blog Post
Performax Labs FitMax: Taking Weight Loss Drinks to the MAX!
Performax Labs relaunches a feel-good fat burning powder FitMax, touting a formula that combines a number of proven synergists for max effectiveness. -
Jan 15, 2018 ![]()
Blog Post
NooWave’s High Performer Nootropic: Unlock Your Mind!
NooWave Supplements has reformulated their productivity nootropic supplement The High Performer to make it even better than before, and now in a powder! -
Dec 21, 2017 ![]()
Blog Post
RAW Synergies Thermo Pre: 2-in-1 Fat Burning Pre Workout
RAW Synergies ThermoPre is a 2 in 1 thermogenic fat burner that can also double as a perfect moderate stim pre workout for fasted cardio days! -
Dec 01, 2017 ![]()
Blog Post
Genius Burn: Smart and Trusted Caffeine-Free Fat Loss
Genius Burn is a well-dosed caffeine-free fat burner that enhances weight loss and improves mood and focus, with ALL trusted, trademarked ingredients. -
Nov 30, 2017 ![]()
Blog Post
Jacked Factory PumpSurge: Pumps & Focus from the ALTIUS Crew
Want pumps and focus while training without the stims? Try the nootropic nitric oxide fueled stim-free pre workout from Jacked Factory -- PumpSurge. -
Nov 21, 2017 ![]()
Blog Post
RAW Synergies Black Lion: Full-Spectrum Testosterone Booster
RAW Synergies Black Lion is a new take on the standard natural testosterone booster that also brings some nootropic supplements to the formula -
Nov 09, 2017 ![]()
Blog Post
EVL ENGN Shred: The Pre Workout For Dieters
EVL Nutrition ENGN Shred is a "weight loss pre workout" supplement that brings focus, energy, & increased metabolism by adding fat burning ingredients -
Oct 15, 2017 ![]()
Blog Post
Keto Connect Podcast with Mike from PricePlow: Supplements for Keto | #4
Need guidance about supplements for keto dieters? Check out Mike's 2017 Keto Connect podcast interview on "Keto for Normies" with Matt & Megha! -
Oct 11, 2017 ![]()
Blog Post
Performax Labs VasoMax: Rethinking the Pump Formula -
Oct 09, 2017 ![]()
Blog Post
Optimizing Brain Performance with Shawn Wells | PricePlow Podcast #2
PricePlow's second podcast was one of the best we'll have, where Shawn Wells (ZoneHalo) discussed optimizing brain performance, including nootropics -
Oct 09, 2017 ![]()
YouTube Video
Optimizing Brain Performance with Shawn Wells | Podcast #2 -
Oct 06, 2017 ![]()
Blog Post
Northbound’s All-Natural Blend: A Stevia-Sweetened Nootropic
Stevia-based nootropic powder! Northbound Nutrition has released a new naturally-flavored / sweetened tub of their popular nootropic supplement BLEND -
Sep 29, 2017 ![]()
Blog Post
Choline Supplements: What’s the Best Form for Focus?
Choline is an essential nutrient that provides the backbone of the learning neurotransmitter acetylcholine; learn which form is best for your needs. -
Sep 28, 2017 ![]()
Blog Post
iSatori Morph Xtreme Brings Energy & PUMPS to iSatori Pre Workouts!
iSatori is jumping back in the headlines after releasing their new monster pre workout Morph Xtreme that's bringing a whole lot of energy and pumps. -
Sep 27, 2017 ![]()
Blog Post
EVL ENGN: Start Your Workout Engine at $0.80/workout!
EVL ENGN is the brand's headlining pre workout that's all about the pumps, focus, and performance. -
Sep 23, 2017 ![]()
Blog Post
Ambrosia Mental Jewels: Daily Herbal-Driven Neuro Enhancer
Ambrosia Mental Jewels is a low stim, brain boosting nootropic supplement featuring Bacognize Bacopa Monnieri and Cordyceps, coming from Marc Lobliner -
Aug 18, 2017 ![]()
Blog Post
AZOTH: A Fully Loaded Caffeine-Free Nootropic
AZOTH is a fully-loaded nootropic supplement developed to increase your motivation, focus, energy, and productivity. -
Jul 27, 2017 ![]()
Blog Post
The Ape SH*T Pre Workout — Go APE on the Weights!
The Ape Shit pre workout is aptly named - from new company Untamed Labs that will have you going Ape next time you step in the gym! -
Jul 14, 2017 ![]()
Blog Post
MAN Sports Brain Bridge: Powdered Brain Power!
Brain Bridge is powerful nootropic supplement from MAN Sports to enhance cognition, focus, and productivity. -
Jul 06, 2017 ![]()
Blog Post
Mind Muscle Nutrition Hydra Focus: Intra Keeps Your Concentration
MInd Muscle Nutrition Hydra Focus is a novel spin on the conventional intra workout that enhances pumps and focus alongside hydration and performance. -
Jun 24, 2017 ![]()
Blog Post
Onnit Alpha Brain – Overrated Cognitive Booster for Beginners?
Onnit Alpha Brain is an incredibly popular nootropic touted by celebrities around the world, but is it really just an over-hyped, overpriced product? -
Jun 01, 2017 ![]()
Blog Post
Apollon Nutrition Hooligan – 600mg Caffeine Pre Workout!!! -
May 05, 2017 ![]()
Blog Post
MPA Supps CelluVOL – Matt Porter’s Personal Pre Workout!
MPA Supplements CelluVOL is the clinically dosed stimulant free pre workout developed by Matt Porter. -
Mar 22, 2017 ![]()
Blog Post
MaxQ Nutrition’s Pre-Training Pre Workout is Maxed Out!
MaxQ Nutrition has crafted a true world beater in their Maxed Out Pre Workout which contains everything you'd want to have a Maxed Out workout! -
Mar 17, 2017 ![]()
Blog Post
DVST8 CRIMSON Pre Workout: Inspired Gets Streamlined
Inspired Nutraceuticals has released a follow up to their popular White Cut pre workout with a more streamlined economical version in DVST8 Crimson. -
Mar 08, 2017 ![]()
Blog Post
Genius PRE Workout: Train Smarter AND Harder
Genius Pre is a clinically dosed, stimulant free pre workout that enhances focus but won't leave you feeling bottomed out from a rush of caffeine. -
Mar 06, 2017 ![]()
Blog Post
Performax Labs NootropiMax – Free Your Mind
Performax Labs enters the nootropics market with NootropiMax, a powerful focus and cognitive boosting supplements. Free Your Mind with NootropiMax! -
Feb 23, 2017 ![]()
Blog Post
Ghost Legend: The Pre Workout Supplement for Legends
Ghost has reformulated their headlining pre workout Ghost LEGEND -- it's now 100% transparent and significantly more powerful. -
Feb 07, 2017 ![]()
Blog Post
Blackstone Labs Hype Extreme: Long-Lasting Pumps & Focus
Hype Extreme is a brand new stimulant free pre workout from Blackstone labs that significantly enhances pumps and focus. -
Jan 19, 2017 ![]()
Blog Post
VMI Sports K-XR: High Energy High-Stim Pre Workout
K-XR is the all new high energy, strength boosting pre workout from VMI Sports that is generating quite a buzz in the industry. -
Dec 28, 2016 ![]()
Blog Post
Repp Sports ReactR: Go Nuclear on your Workouts!
Repp Sports is a brand new supplement company that recently burst onto the scene with their DMHA powered pre workout ReactR. -
Dec 13, 2016 ![]()
Blog Post
C4 Ultimate: Cellucor’s Pinnacle Pre Workout!
Cellucor C4 Ultimate is the *ultimate* pre workout experience from Cellucor that features a mostly transparent label and well-dosed pump ingredients. -
Dec 07, 2016 ![]()
Blog Post
PES Prolific – PEScience is Back in the Pre Workout Game!
PES Prolific brings PEScience back into the stimulant pre workout market - it's a performance and focus centric pre workout for the intelligent lifter -
Nov 26, 2016 ![]()
Blog Post
Jim Stoppani Sued AGAIN. New Class Action Lawsuit
Jim Stoppani has been sued AGAIN. This time, a class action lawsuit was filed in California regarding the ingredient-based claims made by Stoppani. -
Oct 12, 2016 ![]()
Blog Post
RedCon1 Mental Trigger Brings the BRAIN Gains
RedCon1 Mental Trigger: Gamers and "spreadsheet athletes" listen up, the ultimate BRAIN gains supplement is here, and it's your new Mental Trigger. -
Oct 07, 2016 ![]()
Blog Post
Blue Star Elevate: Maximum Mental Muscle Potential!
Blue Star Elevate is an incredibly well crafted nootropic-based supplement that enhanced focus, mood, cognition, and drive. -
Oct 04, 2016 ![]()
Blog Post
Meet the Man Who REALLY Formulated Pre-JYM
Jim Stoppani claims that he formulated Pre-JYM. But do the latest court documents in the lawsuit against them corroborate that? Find out at PricePlow. -
Sep 28, 2016 ![]()
Blog Post
ANS RAVE: Energy For Lifters, Gamers, and Hard Workers!
ANS Performance RAVE is the new mental productivity supplement with an extremely unique, and well-dosed ingredient list including Lion's Mane & DMHA! -
Sep 21, 2016 ![]()
Blog Post
Divided Labs PREVIDE: Serious Pre-Workout.. but at 2 Scoops
Divided Labs PREVIDE is a fantastic-looking pre workout supplement... but at two scoops. The question is, will that be worth it then? PricePlow digs. -
Sep 06, 2016 ![]()
Blog Post
Northbound Nutrition BLEND – Cognitive Energy & Endurance
Blend from Northbound Nutrition is a clinically dosed cognition enhancing supplement perfect for work or working out. Maybe even a gaming supplement! -
Aug 09, 2016 ![]()
Blog Post
Northbound Nutrition PINNACLE: The Pinnacle of Pre Workouts?
The Pinnacle Pre Workout from Northbound Nutrition is a premium pre workout supplement that combines clinical and transparently dosed ingredients! -
Aug 08, 2016 ![]()
Blog Post
RedCon1 Big Noise: Stim-Free Bunker Busting Focus Pumps!
RedCon1 Big Noise is a stimulant-free pre workout supplement that will keep you FOCUSED even without the stimulants: The highest level of readiness! -
Jul 13, 2016 ![]()
Blog Post
Performance Inspired: Mark Wahlberg’s Supplement Brand
Performance Inspired is Mark Wahlberg's new supplement brand! The A-List celebrity and fitness aficionado, Marky Mark, is ready to take on the beast! -
Jun 20, 2016 ![]()
Blog Post
Proccor Ultra Octane – Pumps, Performance, and Recovery
Proccor's Ultra Octane is a new stimulant free pre workout that packs in everything needed for enhanced performance, pumps, and recovery. -
Jun 09, 2016 ![]()
Blog Post
Alphamine Reformulated for Better Feels: The Sexiest Supplement
Alphamine is a fat burning energy drink powder by PES, or PEScience. We think it's the sexiest, best supplement out there. Read why on PricePlow! -
May 20, 2016 ![]()
Blog Post
Transparent Labs PreSeries STIM-FREE: Naturally Heavy Pumps
Transparent Labs PreSeries STIM-FREE is a comprehensive pre workout that offers pumps, focus, endurance, and power all without the use of stimulants. -
May 10, 2016 ![]()
Blog Post
BPI “Best PRE Workout” – Is it Really Though?
BPI Sports has a new keto-targeted product tilted Best Pre Workout, using the keto-inducing power of BHB to help you burn fat for fuel during workouts -
Apr 15, 2016 ![]()
Blog Post
Proccor Pre-RX – Workout Enhancement for Focused Athletes
Proccor has upgraded their monster pre workout Pre-Rx and it's the perfect prescription for your workout. -
Mar 16, 2016 ![]()
Blog Post
Hemavo2 MAX Upgraded (2016)! Get Your Guns Ready!
The King of Pumps is back! iForce Nutrition has reformulated Hemavo2 Max to include a whopping dose of HydroMax and Nitrates. -
Mar 02, 2016 ![]()
Blog Post
Magnum Carne Diem – Seize the Fat Loss!
Carne Diem is the newest non stimulant fat burner from Magnum Nutraceuticals that puts a truly unique spin on carnitine supplements. -
Jan 14, 2016 ![]()
Blog Post
PreSeries BULK – $49 Pre Workout Has Industry Abuzz…
Transparent Labs PreSeries Bulk is a serious pre workout, with efficacious doses of everything you'd want in a pre workout. But is it worth $49?! -
Jan 06, 2016 ![]()
Blog Post
Alpha GPC for Strength CONFIRMED: 600mg/day for Legs!
Alpha-GPC for strength CONFIRMED! A new study found that 600mg daily of Alpha GPC significantly improves leg strength, and possibly more! -
Dec 17, 2015 ![]()
Blog Post
Rich Piana’s 5150 Pre Workout: Involuntary Psychiatric Hold
5150 is a high stim pre workout from Rich Piana and 5% Nutrition specifically made for those that regularly need 2 to 3 scoops of "standard" pre workouts. -
Nov 25, 2015 ![]()
Blog Post
Nitramine 2015: Myokem’s Reformulation for MORE Focus
Myokem Nitramine has been updated as the popular focus pre workout removes picamilon in favor of L-Theanine and Theacrine, and adds ALCAR over LCLT. -
Nov 04, 2015 ![]()
Blog Post
Best Sleep Aid Guide: Supplements, Ingredients, & Herbs
What's the Best Sleep Aid? It depends if you want a full-blown sleep aid supplement, or just a single-ingredient herb or compound. We cover it all! -
Sep 23, 2015 ![]()
Blog Post
MuscleSport Rhino Black – High Energy & Pump Pre Workout
Rhino Black is the newest high energy, pump-centric workout from MuscleSport specifically tailored to give razor focus and skin-splitting pumps! -
May 27, 2015 ![]()
Blog Post
Magnum Limitless: New Pre-Workout Focusing on FOCUS
Magnum Limitless is the new pre workout supplement coming in June. We don't know much about the Limitless ingredients yet, but we're guessing FOCUS! -
Apr 03, 2015 ![]()
Blog Post
ONWARD by Run Everything Labs: Flag Nor Fail’s Health Supplement
The ONWARD Supplement is a new daily immune/energy/focus/mood booster from Flag Nor Fail's Rob and Dana Linn Bailey. But is it worth the price? -
Mar 31, 2015 ![]()
Blog Post
Altius Pre-Workout by Jacked Factory: Go Strong All Day Long
The Altius Pre Workout by Jacked Factory is an Amazon product that is absolutely LOADED and has tons of great reviews. We analyze the ingredients. -
Feb 12, 2015 ![]()
Blog Post
SAN MegaTron – Stim-Free Supplement as Good as its Name
SAN MegaTron is a stimulant-free pre workout supplement that has exciting doses of both nitric oxide boosters AND focus enhancers. And what a name! -
Jan 29, 2015 ![]()
Blog Post
PES ERGONINE – The Once-Per-Day Muscle Supplement
Athletix Ergonine has been touted as a once-daily muscle builder that covers all of your bases for less than a dollar per day. Does it add up? (YES!) -
Jan 17, 2015 ![]()
Blog Post
Amino HP – ANS Performance’s Fully-Loaded BCAA Powder
Amino HP is ANS Performance's answer to all of the BCAA supplements and intra workouts out there. It's fully loaded and knowing ANS, will taste great
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- Mar 17, 2020PrimaForce Choline Bitartrate hit the Hot Deals page:
- 250 Grams is on sale for $21.95 at SBMuscle.com!
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- 250 Grams is on sale for $26.64 at VitaGlo.com!
Choline Price Alerts
The following price alerts are still active:
- Mar 20, 2020SWFT Stims Alpha-GPC 60 Capsules dropped by 25.1% to $29.95 at A1 Supplements
- Mar 20, 2020Country Life Choline 100 Tablets dropped by 33.0% to $6.83 at VitaDigest.com
- Mar 19, 2020Country Life Phosphatidyl Choline Complex 100 Softgels dropped by 10.1% to $14.42 at VitaSprings.com
- Mar 19, 2020Country Life Phosphatidyl Choline Complex 200 Softgels dropped by 22.9% to $15.73 at VitaDigest.com
- Mar 19, 2020NOW Choline & Inositol 100 Capsules dropped by 14.0% to $4.98 at SBMuscle.com
- Jan 31, 2020Twinlab Choline Caps 100 Capsules dropped by 19.7% to $11.05 at VitaCost.com
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Choline Reviews & Videos
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Aug 27, 2019Nootropics for a Competitor: Brandon DaCruz Focuses While Dieting
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Aug 27, 2019Link in Bio!⠀
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Aug 19, 2019CEO Level Nootropic | Cutler Cognition Review
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Mar 23, 2019NutraBio Alpha EAA Strawberry Lemon BOMB!
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Feb 15, 2019NutraBio Alpha EAA: Essential Amino Acids + Nootropics!
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Dec 04, 2018Primeval Labs Mega Pre BLACK Review
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Nov 30, 2018BEST Nootropic Energy Drink | SNS Focus XT Review
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Oct 22, 2018SNS Focus XT Nootropic | CANDY CORN Flavored Supplement Review!
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Sep 10, 2018VMI Sports K-XR Pre Workout Flavor Review (Geographical Flavors?!)
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Aug 20, 2018Performax Labs StimMax Review - HIGH Stim Pre Workout Energy, New Flavors!
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Aug 14, 2018Best Nootropic Stack for Beginners: Expert Shawn Wells Weighs In
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Mar 14, 2018Sparta Nutrition CogniKeto Review: Nootropic for Keto Dieters!
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Oct 09, 2017Optimizing Brain Performance with Shawn Wells | Podcast #2
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