UC-II, or undenatured type II collagen, is a promising new joint supplement / cartilage support ingredient that's been shown to relieve much of the pain associated with issues such as osteoarthritis in the knee[1] and rheumatoid arthritis[2,3,4].
It is actually a patented form of this type of collagen, and is derived from chicken sternum.
UC-II for Joint Pain in Healthy Persons
The most interesting and useful research, however, is a 2013 study where UC-II was used on healthy subjects without any history of arthritis. At 90 and 120 days, participants exhibited a statistically significant improvement in knee extension and pain![5] This was a placebo-controlled study, and the UC-II group fared far better than the placebo group.
It could have effects elsewhere beyond what has been studied, so we are excited about this promising new joint supplement, and think it's worth trying for at least three months alongside appropriate physical therapy and training support.
Dosage
40mg seems to be the universal dosage discussed in studies, but it is uncertain why. We look forward to more research on UC-II using varied dosages to see which works best, but for now, 40mg once per day seems to be the way to to go.
UC-II News on PricePlow
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Apr 22, 2024 
Product News
NOW UC-II, Advanced Joint Relief was created.
Categories: Collagen, UC-II -
Feb 25, 2024 
Product News
The Vitamin Shoppe UC-II Collagen was created.
Categories: Collagen, UC-II -
Sep 24, 2023 
Product News
Healthy Origins UC-II was created.
Categories: Collagen, UC-II -
Jan 05, 2021 
YouTube Video
Tetrahydrocurcumin (CurcuPrime): A Curcumin That Feels BETTER
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UC-II Price Alerts
The following price alerts are still active:
- Jul 29, 2025The Vitamin Shoppe UC-II Collagen 30 Capsules dropped by 18.3% to $22.49 at Vitamin Shoppe
- Jul 20, 2025Source Naturals UC-II 120 Capsules dropped by 11.1% to $46.91 at iHerb.com
- Jun 22, 2025NOW UC-II 60 Vcaps dropped by 6.1% to $16.89 at AllStarHealth
- Jun 12, 2025NOW UC-II, Advanced Joint Relief 60 Vcaps dropped by 6.7% to $20.19 at Amazon
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UC-II Reviews & Videos
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