Citrulline Malate

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Citrulline malate (CM) is a solid supplement choice for athletes when it comes to strength, endurance, and overall blood flow to muscle tissue. It has become an extremely popular performance enhancer in several pre-workout supplements. The compound, a combination of an amino acid and an organic salt, is capable of pumping the muscles, staving off fatigue, and reducing post-exercise muscle soreness -- all without negative side effects.

What is citrulline malate

Urea, which is the waste that's produced after the body breaks down protein, metabolizes nitrogen compounds. It goes through the liver, dissolves in the bloodstream, and is excreted through urine and sweat. There are three components of the urea cycle:

L-arginine
L-ornithine
L-citrulline

Of these three, L-citrulline is the most effective at increasing plasma arginine more effectively than supplementing with arginine or ornithine. This makes L-citrulline especially effective for athletes in training because you can get more from your workouts thanks to the amino acid compound's nitric-oxide-enhancing effects.

This amino acid is often bonded with malic acid to increase absorption. Additionally malic acid increases endurance in synergy with citrulline. Once absorbed and converted into arginine through the urea cycle, this increased arginine substrate results in increased nitric oxide production.

Food sources

Citrulline malate supplementation is beneficial for increasing time to fatigue.

L-citrulline is a non-protein amino acid. It's most notably found in watermelon, but is also appears in these food sources:

Melons
Squash
Pumpkin
Gourds
Cucumbers

Nitric oxide booster

Through its effects on the urea cycle, citrulline acts as a significant nitric oxide booster. Increased nitric oxide production leads to heightened vasodilation, which widens blood vessels and can increase oxygen and nutrient delivery to muscles. Another transient yet highly sought after effect of nitric oxide boosters is increased muscle pumps, leading to a temporarily fuller looking physique.

All things considered equal, this enables longer-lasting, more intense workouts, resulting in bigger muscle gains and increased fat burn.

Considerations

Please note that the FDA does not regulate or oversee citrulline malate -- or any dietary vitamins or supplements, for that matter. Before starting a new supplement, be sure to talk to your doctor about the possible benefits or side effects.

Benefits

There are several ways that CM is helpful to an athlete who specializes in either aerobic or non-aerobic exercise:

Improves endurance so you can train longer
Reduces post-exercise muscle soreness that can otherwise delay progress
Lowers blood pressure.^[8] This may not be a benefit to some, which is why seeing a doctor before using nitric oxide supplements is extremely important.
Increases blood flow and nitric oxide to provide a bigger muscle pump

Muscle efficiency

While working out and following a healthy, protein-rich meal plan can help you reach your fitness goals, taking a CM supplement can give you an extra edge. A study on lab rats shows increased muscle efficiency after taking 250mg of citrulline malate per kg of bodyweight.^[4] The human equivalent is 40mg per kg of body weight, which translates to roughly 3.3g for a 185-pound male.

Reduced muscle soreness

As far as weight lifting, which is the main use for this supplement, there are some real benefits. A study in Spain shows that bench press repetitions increased by almost 53% when the lifters took CM. In addition, it showed a remarkable 40% decrease in muscle soreness after the sets were complete.^[5]

Decreased exhaustion

On top of its muscle-building benefits, it also works well for aerobic exercise. A study published in the journal Medicine and Science in Sports and Exercise demonstrated reduced exhaustion in 17 young, healthy men and women training on a treadmill.^[6]

In another study, when 17 male cyclists were given CM before exercising, post-workout blood samples demonstrated plasma increases of citrulline, arginine, ornithine, urea, creatine, and nitrate, which makes it beneficial for increasing time to fatigue as shown above.^[1]

Recommended dose

When considering both performance and value, an optimal single dose of CM is 3g to 6g.

L-citrulline vs L-arginine

Despite the fact that citrulline is converted to arginine, the amino acid that actually boosts nitric oxide levels, it has been found to be better than supplementing L-arginine due to higher bioavailability and more efficient pathways. This explains its recent popularity over arginine when it comes to nitric oxide supplementation.

Side effects

Citrulline malate is shown to be free from negative side effects according to the Citrudose Pharmacokinetic Study.^[3] It involved eight fasting males, and once tested, they demonstrated that CM is more effective than L-citrulline alone. The combination provides a fast-acting boost to supercharge your workouts and increase muscle gains.

Where to buy

PricePlow is your source for L-citrulline and citrulline malate supplements. You can read more about L-citrulline here and decide which one best suits your needs, but we recommend citrulline malate because it's a powerful supplement that allows for faster absorption.

References

Sureda A., et. al.; European Journal of Applied Physiology "L-citrulline-malate influence over branched chain amino acid utilization during exercise;;" September 2010
Ochiai M, et. al.; "Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men;" International Journal of Cardiology; March 2012
Curis E., et. al; Current Opinion in Clinical Nutrition and Metabolic Care; "Citrulline and the gut;" September 2007
Giannesini B., et. al.; European Journal of Pharmacology; "Citrulline malate supplementation increases muscle efficiency in rat skeletal muscle;" September 2011
Perez-Guisado J, Jakeman PM; Journal of Strength and Conditioning; "Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness;" May 2010
Hickner RC. et. al.; Medicine and Science in Sports and Exercise; "L-citrulline reduces time to exhaustion and insulin response to a graded exercise test;"
Moinard C., et. al.; The British Journal of Nutrition; "Dose-ranging effects of citrulline administration on plasma amino acids and hormonal patterns in healthy subjects: the Citrudose pharmacokinetic study;" April 2008
Figueroa A., et. al.; American Journal of Hypertension; "Oral L-citrulline supplementation attenuates blood pressure response to cold pressor test in young men;" January 2010

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