Nootrol (2 Bottle Combo) by Black Lion Research
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Nootrol by Black Lion Research is a cognitive and nootropic loaded powerhouse designed to help you get through the toughest of tasks with stylistic ease!
Nootrol (The Methodology):
The brain is an exceptionally complex and delicate system. As many of you know there are endless supplements are dozens of compounds reported to be "nootropic" or to increase memory and learning. Many of these supplements simply increase acetylcholine (ACH). Unfortunately increasing ACH is a poor way to increase brain power when it is solely employed. In fact your more likely to have unfavorable side effects and reduced brain function, over time, when using racetams, Noopept etc without the proper ancillaries. Increased ACH is indicated in multiple brain disease states including Parkinsons. Taking a product that only increases ACH and doesnt balance out the other neurotransmitters involved can be hazardous. A testament to this is the widespread comments online regarding negative effects of Nootropic products.
"libido-killing/depression-inducing side effects have been one of the greatest obstacles standing in the way of trying to use any of the racetams consistently (not to mention the emotional dulling)"
"The imbalance between cholinergic activity and dopaminergic activity in the striatum causes a variety of neurological disorders, such as Parkinson's disease."
"many people mention depression symptoms when using racetams, noopept and other things that increase ACH specifically."
Initially with increased ACH there may be an increase in Dopamine and Serotonin but this quickly leads to depletion and side effects related to low dopamine and serotonin levels. NOOTROL, unlike most nootropic products, addresses these deficiencies with additional ingredients included specifically to balance out the high ACH levels. Every action has a reaction and in the brain its no different. Cognitive function involves the participation of many different neurotransmitter systems in a variety of brain areas. The centerpiece of investigation regarding cognitive function has classically been the cholinergic system, but it has become increasingly clear that other transmitter systems interact with cholinergic systems to provide the neural basis for cognitive function. In order for a nootropic product to work well the formula must be well balanced and each effects side effects must be addressed. Many/most nootropic products are either a single ingredient or a mix and match of random "nootropic" ingredients with little rhyme or reason. NOOTROL has been balanced perfectly. Now, everyone can improve their lives by harnessing the power of higher intellect.
Nootrol works in multiple ways to increase cognitive function and brain health. Increased acetylcholine is a part but so is increased cerebral circulation, antioxidant activity and optimizing of neurotransmitters involved in memory, learning and brain power. Nootrol also increases neurotrophic factors such as BDNF and NGF.
BDNF- Brain derived neurotrophic factor
Brain-derived neurotrophic factor (BDNF) is a key protein in brain plasticity and is particularly important for survival of dopaminergic neurons.
BDNF is involved in new neural network formation, neuroplasticity, Long term memory formation, helps to support the survival of existing neurons and encourages the growth, regeneration and creation of new neurons and synapses.
BDNF increases energy metabolism in obese diabetic animals, partly through activating the stress response and inducing UCP1 – an uncoupling protein that creates brown fat, which is easily burned for fuel. BDNF can help with sleep, is antidepressant and can decrease insulin resistance. Unfortunately BDNF decreases with age. Increases in this neurotrophic factor are beneficial to health and cognitive function.
NGF- Nerve growth Factor
Nerve growth factor (NGF) is one of a group of small protein like molecules called neurotrophins (BDNF is another) that are responsible for the development of new neurons, and for the health and maintenance of mature ones.
NGF promotes growth, maintenance, and survival of neurons and axons (part where electrical signal passes). It also helps repair myelin sheath, the coating around the axons (R).
Animal testing has shown that as production of NGF decreases in the brain, one’s ability to form new connections and to retain and access memories is impaired. NGF can save degenerating nerves and restore function. On top of NGFs effects regarding nerve regeneration and neural protection it can help increase serotonin and reduce depressive symptoms. Recent animal studies show that NGF selectively protects acetylcholine activated neurons.
The Silkworm connection.
Silkworms are the larva of the silk moth, whose Latin name is Bombyx mori, which means “silkworm of the mulberry tree.” As you can imagine, the leaves of the mulberry tree are the preferred food of the worms.
As obvious as the second half of the name is, the first half also tells you quite a bit about this insect, as it is a primary producer of silk.
Cultivating silkworms for the production of raw silk has been practiced in China for more than 5,000 years.
While in the larvae stage, the silkworms create an insoluble protein known as silk fibroin. The fibroin is the structural center of
the raw silk the worms create to build their cocoon.
Researchers have found that if you take the silk fibroin and filter it, purify it and hydrolyze it—or break it down into its component amino acids—it has several medicinal and therapeutic benefits, primarily related to brain health. This purified silk fibroin is called Brain Factor-7 (BF-7) for short.
BRAIN FACTOR 7 (BF-7) has been shown to=
Increase IQ in normal healthy subjects.
Improve Working memory
Increase reaction times
Reduces amyloid plaques
Reduces ROS (reactive oxygen species)
Prevents brain cell death
Increases Brain circulation
""Previous studies indicate that BF-7 enhances learning and memory in normal and elderly individuals. Here, we evaluated whether milk containing BF-7 (BF-7 milk) could improve the brain function, with thirty normal university students (21 ± 1.2 years). Two versions of the Paced Auditory Serial Addition Test were used under double-blinded conditions to measure the efficacy of BF-7 milk on learning and memory, especially working memory and attention, and on mathematical ability. As a result, BF-7 milk improved the accuracy of the task more than 3-fold. Furthermore, BF-7 milk protected cultured neu-ronal cells from 3-hydroxykynurenine, a normal endogenous brain stress agent. These results indicate that BF-7 milk enhances memory, attention and mathematical ability in normal persons."
"INCREASED REACTION TIME AND TEST SCORE ACCURACY=
"Results showed that BF-7 reduced the response time by an average of 23% for the Color Trails Making Test. Moreover, BF-7 improved the accuracy of the task around twofold. The results reveal that BF-7 improves brain function for attention and cognitive flexibility"
"BF-7 play a role in the improvement of brain functions by removing oxidative stress, and provide therapeutic potential role of BF-7 to protect nervous system from oxidative damage."
GREATLY ENHANCED MEMORY.
"his results strongly represent that the BF-7 play effectively positive role in the improvement of brain function including learning and memory. Taken together, our results suggested that the BF-7 should be useful for developing strategies protecting nervous system and improving brain function.
In a study published in 2004, researchers divided 98 people between the ages of 19 and 64 into three groups.6 One group received 200 mg of BF-7, the second group took 400 mg of BF-7 and the third group had a placebo every day for three weeks.
At the end of the study period, researchers found that all subjects taking the BF-7 (regardless of dosage) saw an average improvement in the memory index from 105 to 126.6. Similarly, the memory maintenance index in both groups increased from 52 percent to 61 percent.
The 200 mg group specifically saw an increase in memory recall efficiency from 31 percent to 59 percent, as well as a boost in the Intelligence Quotient and Memory Quotient consensus score from 53 percent to 79 percent.
The 400 mg group was even more impressive, boasting an increase from 41.5 percent to 66.5 percent in memory recall efficiency, and increases in the Intelligence Quotient and Memory Quotient consensus score rom 52.5 percent to 91 percent.
Circulation to Brain
Studies have shown that Bombyx mori, as silk fibroin, can increase blood flow to critical areas of the brain involved in memory and learning. This was specifically seen in one study published in 2004, where researchers tested the effects of BF-7 on four normal, healthy students.5
After treating the students with 400 mg of BF-7, researchers tested for improved learning and memory using the K-WAIS scale. They found BF-7 treatment raised IQs from 103 on average to 114.
Researchers then tested blood flow to the brain, particularly those areas associated with learning and memory—the paraphippocampal gyrus and medial temporal area—using the Single Photon Emission Computed Tomography (SPECT). They found that blood flow was, in fact, increased in both areas. Additionally, blood supply also increased.
Centella asiatica/GOTU KOLA
This is a great overall brain supplement but its power lies in its ability to counterbalance the increased acetylcholine levels. Increase Dopamine, increased serotonin as well as a host of other brain benefits.
Increased BDNF, NGF
At least one study has traced back the increase in BDNF to CREB phosphorylation, and the CREB phosphorylation to the activation of MAPKs.
Oral ingestion of centella asiatica has been confirmed to increase dendritic arborization
Reduces amyloid plaques.
Anxiolytic/ anti anxiety. Comparable to valume.
Reduced pain and inflammation.
Increased calmness, Contentment and alertness.
Increased Dopamine, Serotonin and Norepinephrine.
RESULTS: Significant reduction of the corticosterone level in serum and increase of the contents of 5-HT, NE, DA and their metabolites 5-HIAA, MHPG in rat brain were observed. CONCLUSION: The antidepressant effect of total triterpenes of Centella asiatica may be involved in ameliorating the function of HPA axis and increasing the contents of monoamine neurotransmitters.
A very solid addition to the mix Salidroside is included for several reason. Of great importance, as we have discussed, is the importance of catecholamine homeostasis.
Its irresponsible at best to increase only acetylcholine in the hopes of increasing memory at the cost of losing Dopamine and Serotonin. Salidroside increases Norepinephrine, Dopamine and Serotonin which balances out the increase in Acetylcholine. In short we are turning up all of primary neurotransmitters save GABA as GABA is inhibitory and can reduce memory and cognitive function.
Salidroside also increases BDNF, NGF and increases brain health.
" increased expression of brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and nerve growth factor (NGF) mRNAs, and promoted the secretion of these growth factors. The expression of dopamine neurons markers, such as dopamine-beta-hydroxy (DBH), dopa decarboxylase (DDC) and tyrosine hydroxylase (TH), was significantly upregulated after treatment with salidroside for 1-12 days. DA steadily increased after treatment with salidroside for 1-6 days. Thus salidroside can induce rMSCs to differentiate into dopaminergic neurons. "
"stimulated norepinephrine (NE), dopamine (DA), serotonin (5-HT), and cholinergic effects in the central nervous system (CNS). It also enhanced the effects of these neurotransmitters on the brain by increasing the permeability of the blood brain barrier to precursors of DA and 5-HT. "
Research has also shown salidroside to help preserve serotonin by inhibiting the activity of COMT (catechol-o-methyl transferase.) Salidroside can increase serotonin by 30% and decrease COMT by up to 60%.
Salidroside can also increase MTOR expression, endurance, strength and a host of other benefits to us as athletes.
Salidoside is Tyrosol with a sugar molecule attached.
Salidroside is a prodrug to tyrosol.
Tyrosol is basically a much stronger version of Salidroside.
Many of Rhodiola and Salidrosides effects are due to Tyrosol. Using Tyrosol is like cutting out the middle man!
Caffeine is there in very low doses just for a slight boost and for its cognitive benefits. The dose is low enough that it should not be stimulating for most. There is less than what is in a can of coke/ diet coke etc.
Directions: Take 1 Capsule twice daily.
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