Applied Nutriceuticals RPM

intense
super-concentrated
pre-workout

• support energy, drive and focus*
• promote muscle strength and hardness*
• mind blowing pump*

RPM is a trend-setter, an innovative product that has been imitated but never duplicated. RPM is “THE ORIGINAL” anabolic pre-workout in a capsule, and the first formulation to use a high-dose of Icariin to support rapid strength increase along with mind-blowing pumps.* When you want to take your training to the next level but conventional powdered pre-workouts are just not doing it, RPM delivers rapid results, yielding intense energy and focus within 45 minutes, along with alpha-male aggression to help you power through your workouts.* The synergistic formulation provides both instant and cumulative effects, so whether you are in the gym, or doing what you do to perfect your body RPM delivers!*

THE BASICS OF RPM

• Supports N.O. related vasodilation*
• Promotes a healthy testosterone/cortisol balance*
• Promotes blood flow to skeletal muscle*
• Stimulates ion transport*
• Supports vascularity*
• Promotes dopamine/serotonin balance*
• Explosive energy with no jitters*
• Intense mental focus*
• Measureable strength support*
• Unparalleled pumps*
• Thermogenic fat metabolism*
• Muscle strength and hardness*

what makes rpm effective?

A combination of carefully selected ingredients which when combined produce amazing reults like no other pre-workout before it.

l-arginine best

L-Arginine is an amino acid that is necessary for cell division, ammonia displacement, hormone release, and immune function.* Most importantly, L-Arginine is necessary for the production of nitric oxide. Nitric oxide is derived from arginine and oxygen through a process called nitric oxide synthase, and exerts its effects on tissue through cGMP. The inclusion of Arginine in the P-SARM Synthase AI complex allows for a steady, continuous supply of L-Arginine for conversion to nitric oxide, allowing for a more effective product. Numerous research studies suggest the positive effects of L-Arginine and nitric oxide on supporting lean body mass, and possibly even mediating greater growth hormone response.* (4-7,14)

grape seed

OPCs (Oligomeric proanthocyanidins) are suggested by numerous studies to have the support a healthy rate of converting androgens to estrogens (a process known as aromatizing).* Compounds exhibiting aromatase inhibiting characteristics have been suggested to reduce SHBG (steroid hormone binding globulin) as well. This is important because this supports free testosterone, which promotes longer, harder more intense workouts, rapid strength increases, greater protein synthesis, quicker recovery, and increased lipolysis (fat burning). This, coupled with the androgen-mimicking qualities of Icariin, gives the product a unique “hardness” enhancing quality unlike anything else available.* (15-21)

naringin

Naringin, and its novel component Naringenin, also contribute profoundeffects within the P-SARM Synthase AI complex. Naringin (and Naringenin) may help support a healthy testosterone to estrogen balance.* The combination of OPCs and naringenin act synergistically in supporting estrogen balance; allowing for more circulating free testosterone and all of its associated benefits. Naringin and naringenin have also been suggested to enhance the metabolism of caffeine and PDE5 inhibitors such as icariin, allowing for these compounds to be much more effective on a per dose basis.* (22-29)

icariin

Icariin is a potent phytochemical that has been suggested to have profound effects on anabolism.* Icariin exerts its efficacy through several different mechanisms of action: Via competition with glucocorticoids and increasing cAMP levels, by modulating estrogen receptor antagonism and by decreasing prolactin levels.* Several studies suggest that Icariin competes with glucocorticoids for various receptor sites, and thus supports the Testosterone/Cortisol (T:C) ratio.* Icariin may also help support a healthy cortisol balance.* This alone creates an anabolic effect by positively supporting the Testosterone/Cortisol T:C ratio which is a trigger for greater anabolism, protein synthesis, increased aggression, and intensified muscle contractions.* (1-2,9,13-17)

cocoa extract

Cocoa Extract is comprised of several different important constituents that support mood, cognitive awareness, and muscle contraction.* PEA, tyramine, and L-tyrosine are the most prevalent constituents of cacao, and have the biggest impact on the positive effects of the compound. The amino acid tyrosine has psycho-stimulant effects that support cognitive function, because tyrosine is a precursor to the neurotransmitter dopamine. Tyrosine supplementation has been suggested to increase dopamine and norepinephrine levels, which may be helpful for supporting athletic ability and cognitive function.* Tyrosine also has the ability to ward off exercise-related fatigue by creating a favorable dopamine / serotonin ratio, which can positively alter the subject’s state of mind and reduce mental fatigue.* (37-40)

caffeine

Caffeine is a metabolic stimulant that heightens mental alertness and focus and improves muscle contraction and coordination. MXAC also exerts very strong effects on vasodilation in a process that begins with the activation of norepinephrine and the deactivation of cAMP-PDE (the enzyme that breaks down cAMP). When cAMP levels are increased, the blood vessels in skeletal muscle tend to relax and dilate. The result is more voluminous blood flow into the muscle, resulting in bulging vascularity and massive pumps.* Caffeine also contains significant amounts of theobromine; another vasodilator that ups the amount of nutrients and oxygen into the brain and skeletal muscle.* By blocking adenitric oxidesine uptake without activating adenitric oxidesine receptors, Caffeine triggers increased dopamine and serotonin levels which exerts a positive influence on mood and helps the subject maintain an improved state of mind and focus.* (30-36,40)

1. Ying, Pan, Wei-Yun Zhang, Xing Xia, and Ling-Dong Kong, “Effects of Icariin” Biol. Pharm. Bull., Vol. 29, 2399-2403.
2. Ning, H et al. Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells. Urology. 2006 Dec;68(6):1350-4.
3. Jiang, Z. et al Effects of icariin on hypothalamic-pituitary-adrenal axis action and cytokine levels in stressed Sprague-Dawley rats. Biol Pharm Bull. 2006 Dec;29(12):2399-403.
4. Zhang, Z. et al Icariin. Asian J Androl. 2006 Sep;8(5):601-5. Epub 2006 Jun 5.
5. Liu, W. Effects of icariin on expression of nitric oxide synthase isoforms in castrated rats. Asian J Androl. 2005 Dec;7(4):381-8.
6. Xin, ZC Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. Asian J Androl. 2003 Mar;5(1):15-8.
7. Yap, SP, Shen P, Li, J, Lee, LS, Yong, EL. . J Ethnopharmacol. 2007 Jun 2: 17628368 Molecular and pharmacodynamic. J Ethnopharmacol.
8. Tian L, Xin ZC, Yuan YM, Fu J, Liu WJ, Wang LL. Zhonghua Yi Xue Za Zhi. 2004 Jun 2;84(11):954-7.
9. Xin ZC, Kim EK, Lin CS, Liu WJ, Tian L, Yuan YM, Fu J. Asian J Androl. 2003 Mar;5(1):15-8. Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities.
10. LeBail, JC et al Chalcones are 17beta-hydroxysteroid dehydrogenase activities.Life Sci. 2001 Jan 5;68(7):751-61.
11. LeBail, JC et al Effects of phytoestrogens. Life Sci. 2000 Feb 25;66(14):1281-91.
12. LeBail, JC et al Aromatase and 17beta-hydroxysteroid dehydrogenase inhibition by flavonitric oxideids. .Cancer Lett. 1998 Nitric oxidev 13;133(1):101-6.
13. Arayne, LS. Et al Grape fruit juice-drug interactions.Pak J Pharm Sci. 2005 Oct;18(4):45-57. Review.
14. Ho, PC et al. Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds. J Pharm Pharm Sci. 2001 Sep-Dec;4(3):217-27.
15. Fuhr, U Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man. Br J Clin Pharmacol. 1993 Apr;35(4):431-6.
16. Kreider RB, et al. Effects of Coleus forskohlii supplementation on body composition and markers of health in sedentary overweight females. Experimental Biology 2002 Late Breaking Abstracts. LB305: 2002.
17. LEAMON, KB; PADGETT, W; DALY, JW. "Forskolin: Unique diterpene activator of adenylate cyclase in membrane and intact cells" Proc. Natl. Acad. Sci. USA 1981,78,3363-67
18. 18. DE SOUZA, NJ; DOHADWALLA, AN; REDEN, J; Forskolin, A. "Labdane Diterpenoid