The Muscle | Mind Breathrough
Versa-1 is the first of its kind. Take your training to new levels and feel the unique power of this new patent pending breakthrough.*
- Full 30 Day Cycle
- Support Increased Bodyweight Without Increased Food Intake*
- Promote Enhanced LBM to Fat Ratio Without Change in Activity*
- Stacks Well with Pre-Workouts, Amino Acids, and Test Boosters*
- Incredible Real-World Tester Feedback
Analyzing the Ingredients
When Versa-1 was released to USPLabs' Inner Circle, the ingredient profile was also released. So here it is, just two ingredients, with 400mg per capsule:
- N-[2-hydroxy-2(4-methoxyphenyl) ethyl]-3-phenyl-2-propenamide
- Cytidine 5'-diphoscholine
Your first thought is probably "LOL....WHAT?!"
If your second thought is to research this stuff then don't worry, I'm starting to get it together here for you. I'll do my best to put it into laymans terms and provide sources, as they're extremely promising, but there are definitely some things we don't yet fully understand or have access to.First, a few disclaimers:
- There are several dots that have not yet been connected, from both "sides" (both USPLabs and the 'doubters' out there on blogs and forums).
- We are writing this with absolutely no assistance from USPLabs. There is a lot more information forthcoming, but we have absolutely no access to it. USPLabs is simply not yet ready to release what they know. So we'll do this as unbiased as we can.
- We will update this page as more info comes out.
So here we go.
First, let's translate these names. N-[2-hydroxy-2(4-methoxyphenyl) ethyl]-3-phenyl-2-propenamide is more easily known as Aegeline, which we'll use from now on. This is the anabolic part and is the most "major" basis of Versa-1.Cytidine 5'-diphoscholine is Citicoline, a more well-known nootropic (brain enhancer).Now let's get started.
N-[2-hydroxy-2(4-methoxyphenyl) ethyl]-3-phenyl-2-propenamide = Aegeline
Aegeline is the "patent pending" portion of Versa-1. It's titled this way because it's extremely versatile as a supplement.As described in USP's patent, at lower doses, aegeline causes thermogenesis and beneficial cognitive effects. However, in higher doses, it is shown to be far more effective as an anabolic!
So that is why it's also in the New OxyELITE Pro Fat Burner Formula as a supporting ingredient.But in this "Patented Anabolic" now known as Versa-1, Aegeline is the main player, and easily the most hotly contested ingredient of the two.
So what's it doing?
The most important study involves a plant named Anacyclus Pyrethrum. This study mentions how it's been used in India to treat male sexual dysfunction and infertility. It has even been used as an aphrodisiac in India.The study was all about seeing if this A. Pyretheum could increase androgen production.
Extract administration at all the doses produced significant increase in body weight, sperm count, motility, and viability along with serum testosterone, luteinizing hormone, and follicle-stimulating hormone concentrations... Our results suggest that the ethanol solution extract of the roots of A. pyrethrum has androgenic potential...
And the answer was YES, which is awesome - it's androgenic in rats! That's a great start.Meanwhile, A. Pyretheum was shown to improve the sexual behavior in the males in another rat study. These male rats had major bodyweight improvements with a controlled diet! Meanwhile, their sex organs (testes and prostate) improved, and in a similar way that is done when taking testosterone. So the researchers concluded that this has prolonged anabolic and androgenic properties.
Not bad so far! But I'll admit, here's where the dots don't all connect:Nowhere is it stated that aegeline comes from Anacyclus Pyrethrum. What was in this plant that made the rats so successful? There are thirteen alkylamides found in this plant. Is aegeline one of them?
All we know is that the researchers had a preparation in an ethanol solution, but we don't know the exact alkaloids that did the heavy lifting.
Or is aegeline simply similar to some alkaloid that comes from Anacyclus Pyrethrum? I hope not - I hope USPLabs cited a study that directly correlates to its ingredients. The good news is...
Official Studies ARE Coming
USPlabs has stated that they'll be publishing a 90 day study in rats and rabbits (not cheap to do, mind you - this is serious stuff that nearly no other supplement company does!)
But what about Side Effects and Safety Markers from USP?
There was also a pilot study done on safety markers by USP, which I'm sorry to say I also don't yet have access to. I'll update this when I do. But, from the horse's mouth...
Although the compound has been consumed for centuries through food, additional science was conducted,such as determining the maximum tolerated dose or MTD, in two animal species, followed by 90 day sub-chronic toxicity tests...
The results of these studies have demonstrated that the compound is very safe...
A subsequent pilot study in 6 humans confirmed the safety of the ingredient as defined by liver, kidney, sex hormone and thyroid function.
The fact that they're recommending this for up to 8-12 week cycles ON makes me extremely excited.
Back to the Aegeline Science
Now, let's talk about another thing Aegeline works on: It might be a beta(3)-adrenergic receptor agonist as well. This means it could help cut fat.
The study cited by USPLabs itself states that "the compound might be a beta(3)-AR agonist.", which is due to the fact that it helped significantly reduced glucose, triglyceride, cholesterol, and free fatty acids in diabetic rats.
This was then re-confirmed in a follow-up study.
There are a few too many "maybes" and "mights" for us so far, and the rats had a higher equivalent dosage (roughly 2x of a serving of Versa-1 when converted to human dosages), but the fact is, EVERY beta tester was ravenously hungry. Even the ones who wanted to diet down! That is important because it starts to cast doubts on this being a placebo reaction in the alpha testers. This has great (but still not crystal clear) indications that there are some extremely anabolic and lipolytic effects to this stuff.
By the way, it's natural
Note that study  used Aegle Marmelos to get its aegline. This is also known as bael fruit. I only bring that up to mention that aegeline is definitely a natural supplement in that it can be found in nature. We can only hope it's also found in anacyclus pyrethrum, which would strengthen things even more.
So, does beta-3 agonism mean fat burn?
This, too, can be debated. There is not a ton of science fully verifying that b3 activity will help mammals burn fat, but the fact that the extract worked so well in a rat study is extremely promising. But ?3-AR agonist activity is definitely less efficient for fat-burn in humans, so this isn't the primary mechanism... nor is it really our primary goal when taking Versa-1 anyway.
That said, anecdotal evidence is leaning in the favor of some amounts of success in terms of fat burning, or at least of weight-gain without fat gain. Whether its the anabolic mechanism or the lipolytic mechanism that's causing this in the users can be debated, but the fact is, it's working so far.
Now What's the Deal with this TAAR Pathway?
The USPLabs documentation thus far points to a novel new pathway called TAAR1, short for Trace Amine Associated Receptor. There's some evidence that shows that activating this pathway promotes "vigilance" in rats, and gives both brain-enhancement and anti-depressant properties in models.
So, it's not certain, but it sounds like if we activate TAAR1, we can get a bit more psyched up in the gym. This is doubly true with stimulants, which is why USP's been stating to DEFINITELY use Versa-1 with a per workout like Jack3d or Jack3d Micro.
Apparently, the feeling of this activation is hard to describe, but it sounds like you have a bit more "purpose" in your mental actions, if that makes sense.
But what's activating TAAR1 in Versa-1? How? Does it work in humans?
The dots seem unconnected here!
Well, I found out what's going on with this one. Aegeline gets metabolized in the liver into two different compounds: beta-phenylacrylic acid (also known as cinnamic acid) and para-methoxy-octopamine. It turns out that para/meta-octopamine is, in fact, an agonist for TAAR1 [7a, 7b].
The problem is, this isn't exactly the strongest way to activate TAAR1 in humans. ?-PEA and tyramine are better at it - but they're also quite non-bioavailable in supplementation, and don't last long. The "longer" timed reaction of aegeline -> para-octopamine -> TAAR1 activation may be a "beneficial side effect" of this.
But once again, just like the lipolysis, this seems to be a secondary (or tertiary) benefit of aegeline. Worth mentioning, no doubt, but we're still most interested in how it makes Versa-1 anabolic.
In Come the Haters, Doubters, and Slanderers...
So there's a lot of "slightly disconnected" research, and USPLabs still has more stuff to release. I can live with that. Like Marc Lobliner said in his Versa-1 pre-sale video, this is worth trying. The science isn't [yet] bulletproof, but it looks worth a shot if you've got the cash.
That said, there's plenty left to question, and that leaves Versa-1's ingredients open to attack in industry discussion forums and blogs, especially from competing companies. Obviously, that's nothing new for any new product release.One particular blog post primarily attacks the lipolysis portion of this Aegeline research (the ?3 agonism part above), stating that humans are "extremely insensitive" to this mechanism.
Well, I'm not going to argue that. We even mention above that it's probably slightly weak for fat-burn.
But because of the aforementioned post, a great number of readers then wrote the entire Versa-1 product, and for that, I have to argue. Here's why:
- First off, the lipolytic effect of Versa-1 is only one of THREE 'roles' that USPLabs is claiming may happen. In fact, it's not even the main thing we're going for - we are primarily interested in anabolism!!
To write off an entire compound because it might not be good at 1/3 of its roles (even though it did incredibly well in rat studies, which again gives it hope), is far too dismissive.
- Second, the post only attacks the part of aegeline that gets converted to para-methoxy-octopamine. It completely disregards the part about beta-phenylacrylic acid (cinnamic acid), another compound created from aegeline in the liver.
And guess what? It turns out that cinnamic acid and its derivatives may be extremely beneficial to regulating blood glucose levels by stimulating insulin secretion  and it also activates glucose transport via a completely different pathway we haven't even begun to discuss (PI3-K)!! 
So even if para-methoxy-octopamine was 100% completely useless (unlikely), there's still other actions which will give the intended benefits, and they CANNOT be ignored.
So basically, what you have is a probable industry competitor who is selectively attacking one half of one third of all of the research, and calling the entire product useless.
Hey, 1/6 of my hair follicles are now useless, but that doesn't mean I'm entirely bald! Because the other 5/6 produce some beautifully wavy locks!
This is selective science at its worst. I'm not saying USPLabs isn't potentially doing the same thing from the other side - I still have unanswered questions, especially about Anacyclus Pyrethrum - but to call aegeline totally useless because you don't like where 1/6 of the science goes is CHERRY PICKING, and is a total fallacy of incomplete evidence.
My point is, don't write this stuff off just yet. If you want to try it, then go for it, but if you need to know 100% of everything you're taking, you'll need to wait on more research from USPLabs. As a trusted user who has not yet taken it, I'm obviously leaning towards the "try it" side, but it's your body and your choice.
What About the Placebo Effect in Beta Testers?
So USPLabs did its beta testing (they call it "Alpha Testing") with a bunch of guys who only knew that they were getting some "Patented Anabolic". Some guys were dieting, others were bulking (some clean, some dirty), and still others were prepping up for competition.Most were fans of USPLabs products.
So it's not completely unreasonable to wonder if there was some placebo effect going on here. I've had it work for me in the past, and I won't be surprised if it works for me again in the future.
However, the most important thing is that every tester experienced the same results. Those results were:
- Tons of Strength PRs in the Gym
- Incredible Pumps
- A feeling of thermogenesis
- Increased Focus / Cognition / Ambition, with or without a pre workout
- TONS of Hunger
Some of these guys are extremely experience in the industry, not just fans of USPLabs. I'm talking about guys like mr.cooper69 in the anabolicminds.com forum, and TigerFitness.com's own Marc Lobliner, who knows his way around supplements to say the least.But it's the last bullet point that excites me. Even the guys who were dieting, who would have LOVED appetite suppression, were hungry as hell. They craved food -- most craved tons of protein. If they were truly having a great placebo effect, they would have undoubtedly had their hunger switched off.
But the fact that they were hungry shows that this stuff truly may be an anabolic worth trying, with or without more research to come.
And those are my initial thoughts on the whole aegline half of the ingredients in Versa-1. Wow.
Still with me?
On to Citicoline...
Finally. I'm not going to go as in depth here, because the awesomeness of citicoline is basically undisputed for cognitive brain enhancement.
The biggest problem is, how much dosage do you need to get a cognitive bump, and the cost-prohibitiveness of it all. Marc Lobliner himself said that he'd have loved to put it in his supplements in the past, but the problem was the cost.
We don't know the aegeline / citicoline mix in Versa-1 by any means. We just know that there's not more citicoline than there is aegeline.But for those of you who haven't researched it, let's get down to business:Citicoline is also known as CDP-choline and Cytidine 5'-diphosphocholine, as shown on the Versa-1 label.
Citicoline is naturally occurring within your brain, and helps increase another brain chemical, phosphatidylcholine, which is important part of the neural cell membrane. This helps provide a significant amount of "neuroprotection", which essentially means that it halts or slows the loss of neurons. That in turn prevents and/or slows disease progression.
Neuroprotection is great, but we're more interested in cognitive enhancement, since most of us don't have diseases or head injuries. But it's always tough to find good studies on healthy individuals in search of enhancement - the real research money is in protection and repair. So we'll do with what we can regarding these studies.The publication cited by USPLabs is a review of citicoline for different neurological traumas and conditions.
First off, citicoline has been shown in this publication's referenced studies to be very safe. However, it goes on to state that it looks good in theory as an "exciting treatment option" but is extremely tough to evaluate from a statistical standpoint because there are so many mechanisms to be evaluated. Lots of stuff goes on in the brain.In theory? Yeah... this reference isn't really good enough for me. So let's find more.
CDP-Choline: Pharmacological and Clinical Review  is better, in my opinion. It more specifically states how it works, and who it works for.
From this review, we learn that citicoline is almost completely orally bioavailable, and that the cytidine and choline then disperse, and cross the blood-brain barrier, which is extremely important in a nootropic (brain enhancer) -- it reaches your central nervous system.
Once it's reached your CNS, CDP-Choline acts on tons of different neurotransmitters - it doesn't just do one thing. It increases your brain metabolism, and boosts noradrenaline and dopamine levels. This is the exact stuff we want in both a pre workout supplement and a study-aid. That's why it's used for both.
The Improvements We Need From CDP-Choline
There are referenced studies here that also speak of improved learning and memory performance in animals - now this is what we want. I'm happy that it helps schizophrenics and alzheimer's patients, but does it make us work smarter and more efficiently? The models state so, and the tons of anecdotal evidence confirms this as well.
The study then goes on to remind us that it's great for the head trauma patients as well as degenerative diseases, and slows their evolution.And finally, there's no serious side effects ever found.
Now here's the problem with Citicoline: the dosages.
Most people need around 150mg to start to "feel" it, and some hardcore nootropic users will go as high as 1-3 grams per day. Since Versa-1 is a capsule with 400mg, and this is the second ingredient, we know that there's less than (or perhaps equal to) 200mg in there.
So at these smaller dosages, chances are, if you're a fiend for nootropics, you might not notice anything. But any citicoline is worthwhile. It's expensive stuff and you're probably not getting any.
Coupled with the stimulants in your pre workout supplement, however, it becomes a whole new ballgame. You really don't need to add much of anything to take Jack3d or Jack3d Micro from incredible to unbelievable. A dash of Cytidine 5'-diphosphocholine is all it takes, and this is a superb addition flat-out because hardly nobody else is using it, so it's extremely stackable.
Extremely stackable? You mean Versatile? And that's where the name comes from. Citicoline helps in all situations, and if the rest of the science on Aegeline is truth, then Versa-1 has truly earned its name.
To sum things up on the USP Labs Versa-1 Ingredient Profile
USPLabs, we want more research, and I want more data. But after writing this, we also want Versa-1. We want to see and feel for myself.
Stay tuned to our main USPLabs Versa-1 page, which will keep you up to date with all of the best deals.