Top Secret Nutrition BCAA Hyperblend

Never Take Plain BCAAs Alone Again!

You Work Hard - Take The Best!

• Improved Muscle Recovery*
• Enhanced Muscle Protein Synthesis*
• Reduced Muscle Soreness*
• Reduced Brain Fatigue*
• Increased Energy Levels*
• Increased Fat Oxidation*

Top Secret Nutrition's BCAA Hyperblend combines the power of branched-chain amino acids with ingredients designed to promote anabolic activity and enhance absorption to create the future of BCAA supplementation.

Why do people take BCAAs? - One reason, and one reason only to stimulate and support protein synthesis. So why take plain branched chain amino acids when you can take an enhanced BCAA Hyperblend?

We are huge fans of this formula for those of you looking to stay anabolic while on a diet - the review was created not knowing that there is a powdered formula which provides far better value.

Anabolic Branched Chain Formula

Of the 20 amino acids that help build protein, nine of these cannot be synthesized in the human body. These nine compounds are referred to as essential amino acids because they must be consumed through food or supplements. Three of these essential amino acids - leucine, isoleucine, and valine - are branched-chain amino acids, or BCAAs. Unlike the other amino acids, BCAAs are metabolized in muscle rather than in the liver, which means that they play a critical role in muscle development because they reach muscle tissue faster.*

The chemical structure of BCAAs is what makes them so unique. As the name indicates, they have branched carbon chains; it is these side chains that make it easier for the enzymes in your muscle cells to convert BCAAs into energy during exertion. The more BCAAs you have in your muscles, the slower your muscle cells break down muscle fiber. The anabolic stimulus from your training remains the same, but you experience less muscle breakdown, so you can build up more muscle mass.*

BCAAs, which make up about 40% of the free essential amino acids in blood plasma, are used as an energy source during exercise and play an important part in glyconeogenesis (a mechanism for reusing the glucose used for energy in muscle).¹

The Leucine Debate

The research on leucine and how it relates to muscle protein synthesis (MPS) in humans is debated. Some studies report increased MPS while others show suppressed muscle protein breakdown without increased protein synthesis during leucine infusion. One point on which studies agree is that leucine is anti-catabolic. The debate is centered on just how anabolic leucine is in humans. Further studies on this topic conducted by the researchers from the University of Texas Medical Branch (Galveston) have discovered that leucine appears to promote anabolic signaling, but not protein anabolism. In other words, leucine stimulates the signal to activate muscle protein synthesis but does not actually make it happen. Additionally, they found that an infusion of 1.8 grams is sufficient stimulate the anabolic signal.²

Although leucine is definitely the MVP of the BCAA team, it should be combined with the other BCAAs valine and isoleucine for maximum effect.*

Valine and Brain Fatigue

Several research studies have confirmed that taking BCAAs, and in particular valine, before a workout lowers the amount of tryptophan that gets into the brain, thus lessening 5-HTP levels and fatigue. Therefore, BCAA ingestion can help to prevent feeling fatigued during workouts, which will allow you to train harder and longer, encouraging greater muscle growth. BCAA supplementation can also help to support mood and brain function by reducing brain fatigue through this same mechanism.^3,4

Isoleucine Metabolism and Fat Loss

A recent animal study conducted in Japan has suggested that isoleucine is the BCAA that activates the proteins UCP2 and UCP3, which help boost metabolism. Animals in the isoleucine group had lower weight gain and almost 50% less white adipose tissue than the control group.⁵

The BCAA Hyperblend Team

BCAA Blend - A 3:1:1 ratio of leucine (clinically studied 1.8 grams) to isoleucine and valine.

Anabolic Power Blend - We have included ursolic acid and homobrassinolide to enhance the anabolic and muscle protein synthesis stimulating effect of BCAAs.*

Absorption and Effectiveness Blend - Astravar 2.0 and Bioperine help enhance the absorption of the other powerful ingredients.*

Anabolic Power Blend

Ursolic Acid (UA) - is a pentacyclic triterpenic acid with many body-reshaping attributes. Ursolic acid is a very exciting ingredient that has the potential to make a serious impact in sports nutrition industry. Preliminary studies have had some astonishing results.*

• Protect Muscle - Results from a study performed by scientists at the University of Iowa and published in Cell Metabolism suggested that ursolic acid reduced muscle atrophy and stimulated muscle growth. It did this by enhancing skeletal muscle insulin/IGF-I signaling and inhibiting atrophy-associated skeletal muscle mRNA expression.⁶
• Increase Fat Loss - In an animal study to determine the effect of ursolic acid on abdominal fat and weight loss suggested that ursolic acid reduced abdominal fat accumulation. It was also suggested that this was caused by the stimulation of lipolysis and the inhibition of digestive enzyme lipase.⁷

Homobrassinolide - is a potent brassinosteroid found in the mustard plant. A recent set of animal studies suggest that homobrassinolide exhibits anabolic activity in skeletal muscle cells.⁸ These findings suggest that oral application of homobrassinolide triggers selective anabolic response with minimal or no androgenic side effects including:

• Supporting and Promoting Anabolic Activity*
• Supporting Muscle Hyperplasia and Hypertrophy (number and size of muscle fibers)*
• Supporting Muscle Repair*
• Promoting Overall Physical Performance*

Absorption and Effectiveness Blend

Astravar 2.0 - with red beet root, Rhodiola rosea, Astragin, and Bioperine is designed to improve the effectiveness of branched chain amino acid supplementation.^9-13

Astravar 2.0 Helps:

• Boost Nitric Oxide*
• Improve Absorption of Performance Supporting Ingredients*
• Elevate Energy Levels*
• Delay Onset of Fatigue*
• Enhance Recovery*

Vitamin B6 - acts as a coenzyme to many other enzymes that are involved with metabolism in the body. Vitamin B6 plays a key role in amino acid metabolism and is involved in the first step in the metabolism of BCAAs via its role in catalyzing the enzyme aminotransferase.¹⁴

Looking for an energizing boost with your BCAAs? Try Top Secret BCAA Hyperblend Energy powder for all the benefits of BCAA Hyperblend with a caffeinated boost.*

BCAA Hyperblend Frequently Asked Questions

How often should I take the BCAA Hyperblend?

For maxium protein synthesis support, take 4 capsules twice per day.*

Can I take BCAA Hyperblend before I workout?

Yes, many people like to take branched chain amino acids before they workout, and BCAA Hyperblend, because of its anabolic component is a great product to take pre-workout alone, or with your normal pre-workout supplement.

References

1. "Exercise-induced Muscle Damage is Reduced in Resistance-trained Males by Branched Chain Amino Acids: A Randomized, Double-blind, Placebo Controlled Study." J Int Soc Sports Nutr. 9.1 (2012): 20. [Epub ahead of print]
2. "Excess Leucine Intake Enhances Muscle Anabolic Signaling but not Net Protein Anabolism in Young Men and Women." J Nutr. 140.11 (2010): 1970-6. Epub 2010 Sep 15.
3. "A Role for Branched-chain Amino Acids in Reducing Central Fatigue." J Nutr. 136.2 (2006): 544S-547S.
4. Gomez-Merino D, et. al. "Evidence that the Branched-chain Amino Acid L-valine Prevents Exercise-induced Release of 5-HT in Rat Hippocampus." Int J Sports Med. 22 (2001): 317-22.
5. Isoleucine prevents the accumulation of tissue triglycerides and upregulates the expression of PPARalpha and uncoupling protein in diet-induced obese mice. J Nutr. 2010 Mar;140(3):496-500. Epub 2010 Jan 20.
6. Steven D. Kunkel, et. al. "mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass." Cell Metabolism, 13.6 (2011): 627-638.
7. Rao, VS, et. al. "Ursolic Acid, a Pentacyclic Triterpene from Sambucus australis, Prevents Abdominal Adiposity in Mice Fed a High-fat Diet." J Med Food. 14.11 (2011): 1375-82. Epub 2011 May 25.
8. Esposito D, et. al., "Anabolic Effect of Plant Brassinosteroid." FASEB J. 25.10 (2011): 3708-19. Epub 2011 Jul 11.
9. Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans J Appl Physiol 107 (2009): 1144-1155.
10. Lansley, K.E., et al. "Acute Dietary Nitrate Supplementation Improves Cycling Time Trial Performance." Med Sci Sports Exerc. 43.6 (2011): 1125-31.
11. Effects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary results. J Sports Med Phys Fitness. 2010 Mar;50(1):57-63.
12. Tsuchung Chang, Wen-liang Chang, and m Shu-fun Huang. "A Clinically Validated Natural Ingredient that Transports Significantly Greater Amount of Nutrients in Blood Stream into Cells for Truly Improved Bioavailability." Nuliv Science.
13. Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice. J Nutr. 2004 Aug;134(8):1948-52.
14. A novel branched-chain amino acid metabolon. Protein-protein interactions in a supramolecular complex. J Biol Chem. 2007 Apr 20;282(16):11893-903. Epub 2007 Feb.