Nootropics Depot Nicotinamide Mononucleotide
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Nootropics Depot Nicotinamide Mononucleotide
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About Nicotinamide Mononucleotide (NMN) Enteric Coated Tablets
Nicotinamide Mononucleotide (NMN) is a NAD+ (Nicotinamide adenine dinucleotide) precursor that supports cellular health and mitochondrial function. Our enteric coated tablets protect NMN from stomach acid degradation, ensuring optimal absorption through the small intestine's specialized Slc12a8 transporter. This targeted delivery method maximizes bioavailability and supports healthy NAD+ levels throughout your body's vital organs.
Our NMN Story
We spotted a critical gap in the NMN market: most supplements were failing to deliver their full potential due to poor absorption. Standard NMN tablets dissolve in the stomach's acidic environment, where the compound degrades before reaching the small intestine where absorption actually occurs. This fundamental bioavailability problem meant customers weren't getting the NAD+ support they expected from their supplement.
Our solution was developing an enteric coating specifically formulated to protect NMN during its journey through the digestive system. This pharmaceutical-grade coating remains intact in stomach acid but dissolves precisely when the tablet reaches the small intestine's alkaline environment. By ensuring safe passage to the Slc12a8 transporter, our enteric coating delivers significantly higher concentrations of active NMN for longevity and metabolism support than standard formulations.
Benefits
- Supports Metabolic Function: NMN supports healthy glucose metabolism and promotes balanced healthy function in healthy individuals by supporting NAD+ levels.
- Supports Mitochondrial Function: NMN boosts NAD+ concentrations and helps maintain mitochondrial performance across multiple organs including the liver, muscle, kidneys, pancreas, blood vessels, and eyes.
- Promotes Healthy Aging: Regular NMN supplementation supports the natural cellular energy production processes, with research showing benefits in older populations through enhanced cell function.
- Supports Heart Health: NMN supports NAD+ production in blood vessels and supports a healthy response to oxidative stress, supporting healthy circulation and vascular function.
The enteric coating technology protects NMN from stomach acid degradation and delivers it intact to the small intestines where it absorbs through its dedicated Slc12a8 transporter. This absorption pathway means NMN faces no competition from other compounds, resulting in superior uptake compared to standard formulations.
Quality and Standardization
- Enteric Coating Technology: Our specialized enteric coating prevents tablet disintegration in the stomach's acidic environment, ensuring NMN reaches the small intestines intact where it absorbs through the dedicated Slc12a8 transporter.
- Third-Party Testing: Each batch undergoes rigorous identity and purity verification through independent laboratory analysis to confirm exact NMN content and absence of contaminants.
- Optimal Bioavailability: NMN utilizes its own exclusive absorption pathway in the small intestines, maximizing uptake efficiency when protected by our enteric coating.
- Pharmaceutical-Grade Manufacturing: We source high-purity NMN and manufacture tablets under strict quality control protocols to ensure consistent potency and cellular health support across every dose.
Mechanism of Action
- Slc12a8 Transporter Pathway: NMN absorbs exclusively through the small intestine via the specialized Slc12a8 transporter, which provides a dedicated absorption pathway without competition from other compounds that share generic transporters.
- NAD+ Biosynthesis: Once absorbed, NMN directly converts to NAD+ through the salvage pathway, bypassing the rate-limiting steps that affect other NAD+ precursors and providing rapid support of cellular health at the mitochondrial level.
- Organ-Specific Distribution: NMN supplementation promotes NAD+ production across multiple organ systems including liver, muscle, kidneys, pancreas, and blood vessels, supporting comprehensive physiological function through enhanced longevity pathways.
- Metabolic Support: By supporting healthy NAD+ levels, NMN activates sirtuins and PARPs (DNA repair enzymes), which support healthy glucose metabolism and promote the body's natural response to metabolic stress.
Overview of the Science
Research demonstrates that NMN supplementation supports healthy NAD+ levels across multiple organ systems, promoting cellular function throughout the aging process [1]. Long-term studies in animal models reveal that NMN administration supports healthy glucose tolerance and insulin production, particularly under high-fat diet conditions. These metabolic benefits stem from NMN's ability to support sufficient NAD+ production while promoting balanced inflammatory responses in fatty tissue. The compound's effects extend beyond basic metabolism, supporting cellular processes across the liver, muscle, kidneys, pancreas, blood vessels, and eyes.
Clinical investigations show that NMN's benefits appear most pronounced in older subjects, where age-related NAD+ decline creates opportunities for supplementation to support cellular function. The research indicates that regular NMN intake supports cell proliferation and mitochondrial energy production, addressing the fundamental mechanisms underlying age-associated changes. These findings suggest that NMN supplementation supports cellular health as part of comprehensive longevity protocols.
[1] Mills KF, Yoshida S, Stein LR, et al. Cell Metabolism. 2016;24(6):795-806.
Ingredients
Nicotinamide Mononucleotide (NMN):
- 125mg per enteric coated tablet
- β-form crystalline structure for enhanced stability
- Protected from gastric acid degradation
Our NMN tablets utilize pharmaceutical-grade β-nicotinamide mononucleotide in its most stable crystalline form. The enteric coating technology ensures protection from stomach acid while delivering the compound intact to the small intestine, where specialized transporters facilitate optimal uptake. This formulation approach maximizes bioavailability compared to standard cellular health supplements that lack protective coating technology.
LACTOSE FREEGLUTEN FREENON-GMOVEGAN -
Lab Testing Results / Certificate of Analysis (COA)
Find the lot number on your bottle and click on the matching COA below Meet Our Third Party Labs Understanding Your COA- NMNCS1050725
- NMNCS1010825
- NMNCS1021925
- NMNCS1093024
- NMNCS1052725
- NMNCS1061825
- NMNCS1091025
- NMNCS1112825
- NMNCS1040226
- NMRCS1042926
Frequently asked questions
Is Nootropics Depot's NMN enteric coated or regular better?
Our enteric coated NMN is the better choice for most people, as the coating protects NMN from stomach acid and delivers it to the small intestine's Slc12a8 transporter for optimal absorption. Visit nootropicsdepot.com to compare all available NMN options.
How many NMN tablets should I take daily?
Take 1 to 2 tablets daily, ideally in the morning, with or without food.
Should I take NMN in the morning or evening?
Morning is the recommended time to take NMN, aligning with your body's natural NAD+ rhythms. Once or twice daily works well, and it can be taken with or without food.
Can I take NMN on an empty stomach?
Yes, our NMN Enteric Coated Tablets can be taken with or without food. The enteric coating protects NMN from stomach acid regardless of meal timing.
How long before NMN starts working?
NMN can produce immediate effects for some users, with full benefits typically building over 2-3 weeks of consistent daily use.
Why does Nootropics Depot use an enteric coating on NMN?
The enteric coating protects NMN from stomach acid degradation, ensuring it reaches the small intestine where it's absorbed via the specialized Slc12a8 transporter for optimal bioavailability.
What makes Nootropics Depot's NMN different from other brands?
Our NMN uses enteric coating to protect the compound from stomach acid, delivering it directly to the small intestine's Slc12a8 transporter for optimal absorption and NAD+ support.
What is an NMN supplement?
NMN (Nicotinamide Mononucleotide) is a NAD+ precursor that supports cellular energy production, mitochondrial function, and healthy aging. Our enteric coated tablets protect NMN from stomach acid, improving absorption through the small intestine.
