Nootropics Depot (-)-Epicatechin +Piperine

About (-)- Epicatechin 90% + Piperine Tablets

(-)-Epicatechin 90% with Piperine combines a bioactive flavanol extract with a bioavailability enhancer for enhanced absorption. Standardized to 90% (-)-Epicatechin and paired with 6mg of Piperine per tablet, this formulation supports muscle function, cardiovascular health, and cognitive performance through myostatin regulation and improved blood flow.

Our (-)-Epicatechin Story

(-)-Epicatechin supplementation has always faced a bioavailability challenge. Research showed promising effects on muscle growth through follistatin support and myostatin regulation, but most (-)-Epicatechin gets rapidly metabolized and eliminated before reaching meaningful tissue concentrations. Even a high-quality 90% extract faces the same absorption barriers that limit this compound's potential.

Our formulation combines pharmaceutical-grade (-)-Epicatechin extract with strategically dosed Piperine to overcome these metabolic hurdles. Piperine inhibits p-glycoprotein pumps that would otherwise shuttle absorbed (-)-Epicatechin back into the intestines, while also reducing glucuronidation that breaks down the active compound. This bioavailability enhancement delivers more active (-)-Epicatechin to target tissues where it can effectively support supplements for muscle growth and cardiovascular function.

This formulation maximizes the muscle-building and cognitive benefits that made (-)-Epicatechin popular among fitness enthusiasts and biohackers. Instead of requiring higher doses to compensate for poor absorption, our Piperine-enhanced tablets deliver consistent, reliable effects from a practical 200mg serving.

Benefits

• Promotes Muscle Growth And Strength: Supports follistatin levels while regulating myostatin signaling, creating an optimal environment for muscle development and enhanced strength gains.
• Supports Cardiovascular Function: Promotes healthy blood flow and circulation, supporting overall heart health and vascular function through flavanol activity.
• Benefits Cognitive Tasks: Enhances memory and executive function through improved cerebral circulation and neuronal support mechanisms.
• Improves Physical Performance: Boosts energy levels and exercise capacity, with users reporting increased strength and endurance even on non-training days.

Piperine amplifies these benefits by preventing the premature elimination of (-)-Epicatechin from your system. Piperine regulates p-glycoprotein function and glucuronidation processes, ensuring maximum bioavailability and sustained therapeutic levels throughout the day.

Quality and Standardization

• 90% (-)-Epicatechin Standardization: Our tablets are standardized to 90% (-)-Epicatechin by HPLC, ensuring consistent levels of the bioactive flavanol compound in every dose.
• Piperine Enhancement Formula: Each tablet includes 6mg of Piperine to regulate p-glycoprotein function and glucuronidation, significantly improving (-)-Epicatechin bioavailability and absorption.
• Third-Party Purity Testing: We verify both product purity and identity through comprehensive laboratory testing to ensure our (-)-Epicatechin meets pharmaceutical-grade quality standards.
• Precise Tablet Formulation: Our 206mg tablets deliver exactly 200mg of (-)-Epicatechin with 6mg Piperine, providing optimal dosing consistency for reliable Fitness and cognitive support.

Mechanism of Action

• Myostatin Pathway Regulation: (-)-Epicatechin modulates myostatin signaling through its interaction with cellular pathways that control muscle protein synthesis, while simultaneously supporting follistatin production to create an environment conducive to muscle development.
• P-glycoprotein Inhibition: Piperine blocks the efflux pump activity of p-glycoprotein in intestinal cells, preventing absorbed (-)-Epicatechin from being pumped back into the digestive tract and ensuring greater systemic availability.
• Nitric Oxide Pathway Enhancement: (-)-Epicatechin promotes endothelial nitric oxide synthase (eNOS) activity, leading to increased nitric oxide production that supports vasodilation and improved blood flow to both muscle and brain tissue.
• Glucuronidation Suppression: Piperine inhibits phase II detoxification enzymes that conjugate (-)-Epicatechin with glucuronic acid, slowing the compound's metabolism and extending its active presence in circulation.

Overview of the Science

(-)-Epicatechin demonstrates notable neuroprotective properties through multiple mechanisms beyond its muscle-building effects. Research suggests that this flavanol crosses the blood-brain barrier and accumulates in brain regions associated with learning and memory, where it supports cognition through enhanced cerebral blood flow and neuroplasticity. Studies indicate that (-)-Epicatechin can reduce neuroinflammation, protect mitochondrial function, and prevent cognitive impairment in various neurological conditions ^[1]. The compound appears to modulate inflammatory pathways while supporting cellular energy production in neural tissue, creating an environment conducive to optimal brain function.

The inclusion of Piperine significantly enhances (-)-Epicatechin's therapeutic potential by addressing key bioavailability challenges. Without Piperine, much of the absorbed (-)-Epicatechin undergoes rapid glucuronidation and efflux back into the intestines via p-glycoprotein transporters. Piperine effectively inhibits both of these elimination pathways, allowing for sustained plasma levels of the active compound. This enhanced bioavailability translates to more pronounced effects on muscle protein synthesis, vascular function, and cognitive performance, making the combination particularly valuable for individuals seeking comprehensive support for both physical and mental performance through longevity-focused supplementation.

^[1] Pang L et al. Oxid Med Cell Longev. 2022;2022:5181742.

Ingredients

Camellia sinensis Extract (leaf):

• 200mg per serving
• Standardized to 90% (-)-Epicatechin
• Enhanced with 6mg Piper nigrum Extract (95% Piperine)

The 90% (-)-epicatechin standardization represents one of the highest concentrations available, ensuring you receive 180mg of pure (-)-epicatechin per tablet. This precise standardization matters because epicatechin content can vary dramatically between different tea extracts. The addition of 95% piperine from black pepper extract supports enhanced absorption, helping your body utilize more of the epicatechin you're taking.

Lab Testing Results / Certificate of Analysis (COA)

• ECPCS1012225A
• ECPCS1021225
• ECPCS1061625A
• ECPCS2061625A
• ECPCS1090225
• ECPCS1092425
• ECPCS1101025A
• ECPCS1110525A
• ECPCS1121825
• ECPCS1031826A