Nootropics Depot Andrographis Paniculata
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Nootropics Depot Andrographis Paniculata
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About Andrographis paniculata Capsules
Andrographis paniculata capsules deliver 50% andrographolides, the primary bioactive compounds that make this traditional herb so effective. Known as "King of Bitters," this standardized extract supports immune function, supports a healthy inflammatory response, and supports antioxidant activity.
Our Andrographis Story
Traditional herbal supplements often lack consistent potency, leaving users uncertain about the active compounds they're actually getting. While Andrographis paniculata has been valued in Ayurvedic and Traditional Chinese practices for centuries, most commercial extracts provide inconsistent andrographolide levels, making it difficult to achieve reliable benefits.
Our extract delivers exactly 50% andrographolides by UPLC analysis, ensuring you get meaningful amounts of the compounds responsible for this herb's reputation. This precise standardization transforms an unreliable traditional herb into a dependable supplement that supports cellular health, respiratory function, and overall immune response with every capsule.
Benefits
- Supports Immune Function: Supports your body's natural defense mechanisms through andrographolides, which help maintain healthy immune system response and respiratory function during seasonal challenges.
- Supports a Healthy Inflammatory Response: Promotes a balanced inflammatory response throughout the body, supporting overall wellness and helping maintain comfort during daily activities.
- Supports Antioxidant Activity: Supports the body's natural antioxidant defenses while promoting healthy oxidative balance, contributing to cellular health and vitality.
- Supports Healthy Neurological Function: Supports healthy cognitive function through its interaction with inflammation and oxidation pathways in the brain, promoting mental clarity and neurological wellness.
Andrographolides work across multiple pathways to support organ health and longevity. The standardized 50% extract ensures consistent potency, delivering reliable bioactive compounds that support your body's natural processes and maintain optimal health across multiple systems.
Quality and Standardization
- Standardized 50% Andrographolides: We guarantee a minimum of 50% andrographolides by weight, verified through HPLC analysis to ensure consistent potency of the primary bioactive compounds responsible for the herb's beneficial effects.
- Third-Party Purity Testing: Every batch undergoes comprehensive testing by independent laboratories for heavy metals, pesticides, microbiological contaminants, and adulterants to ensure our andrographis supplements meet pharmaceutical-grade purity standards.
- Premium Sourcing Standards: Our andrographis paniculata is sourced from sustainable farms in Southeast Asia where the plant grows naturally, ensuring optimal concentrations of active constituents compared to synthetic alternatives.
- Capsule Formulation Precision: Each 200mg capsule delivers exactly 100mg of andrographolides with consistent fill weights and dissolution rates, manufactured in our cGMP-certified facility for reliable dosing accuracy.
Mechanism of Action
- Andrographolide Accumulation: The active andrographolides concentrate in liver and spleen tissues where they modulate immune cell activity and support the body's natural defense mechanisms during seasonal challenges.
- NF-κB Pathway Modulation: Andrographolides help regulate the nuclear factor-kappa B signaling pathway, which controls inflammatory gene expression and supports a balanced inflammatory response throughout the body.
- Antioxidant Enzyme Activation: The compounds enhance activity of endogenous antioxidant enzymes like superoxide dismutase and catalase, supporting cellular health from oxidative stress.
- Respiratory Support: Andrographolides help maintain healthy respiratory tract function by supporting the integrity of epithelial cells and promoting normal mucus clearance mechanisms.
Overview of the Science
Research suggests andrographolides exert their beneficial effects through multiple molecular pathways in the body [1]. Studies indicate these compounds support healthy immune cell activity by influencing cytokine production, with particular effects on interleukin and normal cell growth regulation pathways that support the body's natural inflammatory response [2][3]. The andrographolides appear to concentrate in liver and spleen tissues, where they interact with immune surveillance cells and support the body's natural defense mechanisms against pathogens [4]. Additional research suggests these bioactive compounds may cross the blood-brain barrier, potentially supporting healthy neurological function through their antioxidant properties and ability to support healthy oxidative balance in neural tissue [5][6].
Clinical investigations reveal that andrographolides support healthy respiratory function through direct effects on lung tissue and airway function [7]. Studies suggest these compounds help maintain healthy mucus production and ciliary clearance while supporting the respiratory system's natural defense mechanisms [8]. Research indicates that andrographolides also support healthy cellular energy metabolism by promoting mitochondrial function and supporting protection against oxidative stress in various organ systems [9]. This multitarget approach explains why traditional practitioners have valued Andrographis paniculata for centuries as a comprehensive health-supporting herb, with modern science now validating many of these traditional applications through rigorous cellular health supplements research [10].
[1] Rajanna S et al. Phytomedicine Plus. 2021;1(3):100087.
[2] Sheeja K et al. Int Immunopharmacol. 2010;10(12):1519-1526.
[3] Puri A et al. J Nat Prod. 1993;56(6):995-999.
[4] Cattuzzato L et al. Bioengineering. 2025;12(1):37.
[5] Shen T et al. J Ethnopharmacol. 2010;131(2):466-472.
[6] Kumar A et al. Int J Biol Pharm Res. 2006;2(2):144-146.
[7] Niranjan A et al. Mol Cell Biochem. 2007;301(1-2):125-131.
[8] Zhang XF et al. Clin Exp Pharmacol Physiol. 2000;27(5-6):358-363.
[9] Coon JT et al. Planta Med. 2004;70(4):293-298.
[10] Hu XY et al. PLoS One. 2017;12(8):e0181780.
Ingredients
Andrographis paniculata:
- Andrographis paniculata extract
- 50% Andrographolides by HPLC
- 200mg per capsule
Our 50% andrographolides standardization represents the gold standard for pain and inflammation support through botanical extracts. This high concentration ensures you receive therapeutic levels of the bitter compounds responsible for andrographis's traditional reputation as "King of Bitters." The HPLC verification guarantees precise andrographolide content, which is critical since lower-grade extracts often contain inconsistent levels of these bioactive diterpenes. This standardization level delivers the same compound concentrations used in clinical research, making our extract particularly valuable for anti oxidative stress supplements applications where consistent potency determines therapeutic outcomes.
LACTOSE FREEGLUTEN FREENON-GMOVEGAN -
Lab Testing Results / Certificate of Analysis (COA)
Find the lot number on your bottle and click on the matching COA below Meet Our Third Party Labs Understanding Your COA- APACS1111424A
- APACS1032825
- APACS1052825
- APACS1060225A
- APACS1061125
- APACS1011326A
- APACS1041326
- APACS1062426
Frequently asked questions
How long until andrographis starts working?
Andrographis can produce immediate effects, with full benefits typically building over 1-2 weeks of consistent daily use.
How do andrographolides support immune function?
Andrographolides support immune function by influencing cytokine production, including interleukin and cell-signaling pathways, helping maintain a healthy immune response. They also concentrate in liver and spleen tissues, where they interact with immune surveillance cells to support the body's natural defenses.
Can andrographis cross the blood-brain barrier?
Research suggests andrographolides can cross the blood-brain barrier, which may contribute to Andrographis paniculata's support for healthy neurological function.
Why does Nootropics Depot use UPLC analysis for andrographis?
UPLC analysis is the gold standard for verifying andrographolide content because it provides precise, accurate quantification of active compounds. This ensures every batch of our Andrographis paniculata is confirmed at 50% andrographolides, not just labeled that way.
Is Nootropics Depot's andrographis third-party tested?
Yes, every batch of our Andrographis paniculata is third-party tested to verify the 50% andrographolides standardization. We test for both purity and potency before any product ships.
How should I take andrographis capsules?
Take one capsule daily, with or without food. Effects may be noticeable right away, with full benefits typically building over 1 to 2 weeks of consistent use.
Is andrographis safe long-term?
Andrographis paniculata is generally well-tolerated, though most research supports use in shorter cycles rather than continuous long-term use. We recommend consulting a healthcare provider if you plan to use it beyond 8-12 weeks.
What is andrographis?
Andrographis paniculata is a traditional herb long used in Ayurvedic and Traditional Chinese practices, known for its bitter compounds called andrographolides. These bioactives support immune function, a healthy inflammatory response, and antioxidant activity.
