Musclesport Multi Vita Revolution

EVERYDAY MULTIVITAMIN

• A full spectrum of vitamins and minerals to optimize health*
• Fruits & Greens Whole Food Complex
• Antioxidant Complex
• Advanced Enzyme Blend

Description

Have you ever noticed that talking about dieting or calorie-restriction is similar to a beacon for some nutritionist or dietitian to swoop in and remind you all about how foods have vitamins and minerals and how multivitamins “just aren’t the same?”

Have you also noticed that people who make a big deal out of vitamins and minerals from food sources also tend to be overweight? That’s because these individuals have overemphasized the micronutrients relative to the macronutrients and calories.

Of course, vitamins and minerals are very important, but it’s not exactly difficult to see the error in justifying eating pizza solely because it has B vitamins in the crust.

Multi Vita Revolution is a better way.

• Micronutrients - A full spectrum of vitamins and minerals to optimize health and keep the body in tip-top condition.
• Fruits & Greens Whole Food Complex – Packed chock full of phytonutrients to get you all the benefits of the whole plant, not just the vitamins and minerals.
• Antioxidant Complex – Free radicals wreak havoc in the body. Ingredients like MSM, Green Tea, and Grape Seed stop them dead in their tracks.
• Advanced Enzyme Blend - A specialized mixture of enzymes facilitate the proper digestion of foods to help get more nutrients out of the digestive tract and into the body!

Whole foods have tons of benefits, but the notion that vitamins and minerals from food are better than from a multivitamin is hogwash.

They are the same, but food has OTHER stuff. In every case, calories are present, but things like phytonutrients are beneficial and found in vegetables, so MSI has added those to Multi Vita Revolution as well!

Long story short, Multi Vita Revolution has all of what you need and none of what you don’t!

Get your vitamins, your minerals, your phytonutrients, and all those other helpful phytonutrients found in food. Ditch the excess Calories. Get Multi Vita Revolution - the Best Multivitamin in Sport!

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Supplement Facts

Ingredient Profile

Vitamin A

Vitamin A is principally found in animal products such as meat, eggs, fish, and dairy as retinol. Provitamin A, carotenoids, are found in orange-colored plants – usually as beta-carotene, but there are over 600 known carotenoids.

• Supports normal vision.
• Helps with collagen formation for strong connective tissues and smooth skin.
• Essential for reproduction by stimulating spermatogenesis, oogenesis, and embryonic growth.
• Antioxidant within the cell membrane.

Vitamin C

Vitamin C is the classic immunity vitamin. However, this is just one of Vitamin C’s many important roles in the human body.

• Supports a healthy immune system, ensuring the best protection from colds.
• Can speed the recovery from colds in athletes.
• Helps in the formation of cartilage, bones, and teeth.
• Protects the body from free radicals.

Vitamin D

The sunshine vitamin is well known for its role in bone health, and as is so often the case, it does much more. Vitamin D has numerous vital roles.

• Aids in calcium absorption and reduction of falls for improved bone health.
• Vitamin D metabolites strengthen muscle contractions
• May help maintain normal blood pressure.
• Improves mood and nervous system health.
• May support a healthy appetite.
• Enhances sex-hormone synthesis.

Vitamin E

The tocoperhols (vitamin E) may be the most potent of the antioxidant vitamins.

• Powerful antioxidant.
• A cell signal that helps regulate the growth of smooth muscle.
• May help prevent infertility and atherogenesis.

Thiamin

Thiamin and the other B vitamins have a major role in metabolism and energy production.

• Facilitates conversion of pyruvate to acetyl-CoA for efficient energy metabolism.
• Helps with the metabolism of non-traditional sugars, such as ribose.
• Supports the health and function of neurons.

Riboflavin

Riboflavin (vitamin B2) forms flavin adenine dinucleotide (FAD), which along with NAD, moves back and forth through the mitochondrial membrane to form ATP.

• Can help with skin, hair, and nail health.
• Aids in red blood cell formation.
• May prevent muscle cramps.

Niacin

Similar to riboflavin and FAD, niacin (vitamin B3) is required to form nicotinamide adenine dinucleotide (NAD). NAD performs the same function as FAD and may also play a role in normal aging.

• Improves blood flow and vascularization.

Vitamin B6

Like the other B’s, B6 is heavily involved in energy metabolism. It is a cofactor in over 100 reactions, many of which within the muscle, where it helps with glycogen utilization.

• Enhances muscle glycogen access and use.
• Supports brain development and function.

Vitamin B12

Cobalamin (B12) may be the most popular of the B vitamins. Indeed, B12 does help with energy as well as oxygen transport and nervous system function.

• In B12-deficient athletes and ill persons, supplementation with B12 enhances endurance.
• Involved in the replication of DNA.

Biotin

Biotin is also known as vitamin B7. Similar to other B vitamins, it is involved in glucose metabolism. Biotin also helps in protein and amino acid metabolism.

• Helps to produce amino acids.
• Plays a role in glycogen synthesis.
• Forms intermediate compounds in the tricarboxylic acid cycle.

Pantothenic Acid

Pantothenic acid (B5) is one of the cooler B vitamins. Its main function is in the rate limiting step in coenzyme-A formation (as in acetyl-CoA – gateway to aerobic metabolism).

• Supports proper adrenal function.
• May reduce perceptions of stress.

Vitamin K

Vitamin K can principally be found in two forms, phylloquinone or menaquinone. Most known for blood clotting, vitamin K has several functions throughout the body.

• Improves bone health by facilitating calcium and osteocalcin binding.
• Strengthens teeth by aiding in the production of dentin.

Folic Acid

Folic acid, or folate, is the fetal vitamin (vitamin B9). Despite being known for healthy babies, folate has at least a dozen other functions. Here are a few:

• Reduces incidence of neural tube defects during embryonic development.
• Low folate levels are correlated with liver damage.

Boron

Boron is a mineral that may help with muscle growth. Interestingly, boron is also essential for plant growth. Weird! It’s good for humans too.

• May increase free testosterone to aid in muscle growth.
• Plays a key role in bone growth and wound healing.
• Can prevent vitamin D deficiency.

Calcium

Calcium is a common customer in milk and other dairy products. It’s one of the reasons milk is so effective for helping build muscle.

• A signal for muscle contractions lasting longer than 20 seconds.
• The major component of bones.
• One of the primary electrolyte minerals.

Phosphorus

Phosphorus is another mineral essential for bone health, like calcium and vitamin D, but it doesn’t get as much love. In addition, phosphorus has a good deal of other functions.

• Form high-energy molecules like ATP.
• A component of DNA and RNA.
• Supports healthy bones.

Iodine

Iodine is a key weight-loss mineral. At one time, most people were deficient in iodine, which is why we now have iodized salt. However, as more people turn to natural salts, iodine deficiencies are becoming a problem once again.

• Forms thyroid hormones that stimulate fat loss.
• Improves cognitive functioning.
• Can reduce the severity of thyroid cancers.

Magnesium

Magnesium is involved in over 300 reactions throughout the body. Most of these reactions are tied to athletic performance in at least one way.

• Magnesium participates in processes that generate ATP
• Involved in protein synthesis.
• Helps with muscle contractions.
• Increases total work output.
• Supplementation enhances endurance and peak oxygen consumption.

Zinc

Supplemental zinc has benefits that extend far beyond what can be contained in a single summary. Here are some of the highlights.

• Improves sleep quality.
• Enhances mitochondrial function, which may improve endurance.
• Prevents exercise-induced decreases in thyroid hormones and testosterone – very important for hard-training athletes.

Selenium

This mineral is most abundant in Brazil nuts – just one brazil nut has a whole day’s worth of selenium and then some! That’s good news, as selenium has a pronounced role in good health and exercise recovery.

• Important for thyroid function and body weight regulation.
• May increase testosterone and IGF-1
• Can help with carbohydrate metabolism.

Copper

Copper has a number of interactions with another popular mineral, iron. They work together principally to foster iron’s purposes, but copper has a few of its own unique properties.

• May support healthy brain function.
• Supports well being.
• Supports reductions in oxidative stress and cardiovascular health.

Manganese

Similar in name and in function, manganese often can stand in for magnesium in metabolic reactions due to comparable coordination and charge. Some of manganese’s unique functions include:

• Forming the most abundant antioxidant in mitochondria, manganese superoxide dismutase.
• Producing enzymes and proteoglycans for healthy bones and joints.
• Involved in glutamine synthesis.

Chromium

Chromium may have the most superhero of names, which extends so far as to be implicated for the prevention of “syndrome X.” Its functions are pretty super too.

• Increases carbohydrate metabolism and glucose disposal.
• May support healthy blood lipid levels.
• Supplementation may increase muscle gains while decreasing body fat.

Fruits & Greens

Fruits and vegetables are an essential component of a healthy diet, and they are one of the few examples of a “more is better” approach that does not lead to overconsumption detriments.

• Over 10 different plant-based ingredients provide phytochemical sustenance.
• Contains powerful antioxidants.
• High fruit and vegetable consumption decreases all-cause mortality.

MSM

Otherwise known as methylsulfonylmethane, MSM is an antioxidant and anti-inflammatory agent with roles in joint health as a source of sulfur.

• Reduces exercise-induced oxidation.
• May decrease muscle damage.
• Studies have found patients to experienced reduced joint discomfort with MSM supplementation.

Green Tea

Green tea contains the powerful antioxidant EGCG and other catechins that have been observed to have several beneficial effects on health and body composition.

• May reduce body fat mass.
• Increases fat oxidation.

Alpha Lipoic Acid

Alpha-Lipoic Acid (ALA) is a potent antioxidant in the mitochondria that offers protection to several organs as well as reducing the potential for aging from dysfunctional mitochondria.

• Reduces general oxidation within the body.
• Enhances blood flow.
• May improve nervous system function and neurogenesis.

Coenzyme Q10

CoQ10 is a very heart-friendly antioxidant. It has a role in ATP generation along the electron transport chain of the mitochondria.

• A recent investigation on CoQ10 supplementation for four years reduced cardiovascular disease mortality. A follow-up 12 years later found that although supplementation was discontinued, patients were still experiencing benefits and living longer.
• Reduces lipid peroxidation.
• May enhance exercise capacity.

Pycnogenol

Pycnogenol is pine bark extract (specifically, French maritime pine bark extract) that is mostly procyanidins (such as in blueberries). Despite sounding relatively ordinary, pycnogenol is one of the most interesting supplements available.

• Increases blood flow in clinical and healthy persons and supports venous insufficiency.
• Improves attention and cognition.
• Fosters good skin health and quality.
• Promotes healthy cholesterol levels.
• Prevents symptoms of jet lag.

Grape Seed Extract

Grape seed is another with procyanidins, but it also contains tannins – another phytonutrient.

• May decrease aromatase, decreasing the conversion of testosterone to estrogen.
• Helps with appetite regulation.
• Supports a healthy cardiovascular system.

Saw Palmetto Extract

Saw palmetto is an ingredient derived from Serenoa Repens fruit with a particularly prominent role in men’s health.

• Promotes a healthy prostate.
• May reduce the conversion of testosterone to DHT.
• Enhances hair regrowth in male pattern baldness, sexual function, and quality of life.

Lutein

Lutein is a carotenoid, or provitamin for vitamin A. High concentrations are found in eggs, and provide much of the foods function as an antioxidant and proponent of eye health.

• Supports proper vision.
• Antioxidant effects.
• May protect against chronic disease.

Piperine

Piperine is an extract of black pepper fruit that works well in conjunction with other supplements.

• Prevents supplements from attacking enzymes
• Promotes absorption.

Advanced Enzyme Blend (protease, amylase, lipase, cellulase, lactase, betaine)

Digestive enzymes increase the digestion and absorption of nutrients while also reducing potential adverse reactions.

• Inclusion of lactase may increase tolerance to lactose.
• Protease and betaine facilitate protein and amino acid digestion.
• Amylase, lipase, cellulase, and lactase promote carbohydrate and lipid digestion.

FAQs

Q: Can’t I just get enough vitamin and minerals from eating a varied diet?

A: Yes, this is possible. However, it’s unlikely that all of the daily needs are met on a daily basis. This is especially true for people who are diet (calorie) conscious, as chances are, either carb-rich or fat-rich foods are limited. Any sort of dietary restriction opens the door to vitamin and mineral insufficiency. Multi Vita Revolution eliminates that possibility.

Q: What makes Multi Vita Revolution different from other multivitamins?

A: Multi Vita Revolution is a state-of-the-art multivitamin engineered to meet the high demands of athletes. It supplies all of the essential micronutrients, and goes 5 steps beyond to support joint health, the vascular system, digestion, immunity, and total well-being.

Q: What is the best way to use Multi Vita Revolution?

A: As a dietary supplement, for optimal absorption, take ½ serving (1 capsule) with breakfast and ½ serving (1 capsule) with dinner.

Q: What other MuscleSport products should I use with Multi Vita Revolution?

A: No other supplements need to be used to get enough vitamin and minerals. However, incorporating Life Shield offers another level of total body production not provided by micronutrients or plant powders on their own.

References

Vitamin A

1. Zile, M. H., & Cullum, M. E. (1983). The function of vitamin A: current concepts. Proceedings of the Society for Experimental Biology and Medicine, 172(2), 139-152.
2. Dowling, J. E., & Wald, G. (1960). The biological function of vitamin A acid. Proceedings of the National Academy of Sciences, 46(5), 587-608.
3. Ross, A. C., & Gardner, E. M. (1994). The function of vitamin A in cellular growth and differentiation, and its roles during pregnancy and lactation. In Nutrient Regulation during Pregnancy, Lactation, and Infant Growth(pp. 187-200). Springer, Boston, MA.

Vitamin C

1. Moyad, M. A., & Combs, M. A. (2007). Vitamin C Dietary Supplements: An Objective Review of the Clinical Evidence. Parts I-III. In Seminars in Preventive and Alternative Medicine. Elsevier Inc..
2. Stone, N., & Meister, A. (1962). Function of ascorbic acid in the conversion of proline to collagen hydroxyproline. Nature, 194, 555-557.
3. Gale, C. R., Martyn, C. N., Winter, P. D., & Cooper, C. (1995). Vitamin C and risk of death from stroke and coronary heart disease in cohort of elderly people. Bmj, 310(6994), 1563-1566.

Vitamin D

1. Littlejohns, T. J., Henley, W. E., Lang, I. A., Annweiler, C., Beauchet, O., Chaves, P. H., ... & Lopez, O. L. (2014). Vitamin D and the risk of dementia and Alzheimer disease. Neurology, 83(10), 920-928.
2. Spedding, S. (2014). Vitamin D and depression: a systematic review and meta-analysis comparing studies with and without biological flaws. Nutrients, 6(4), 1501-1518.
3. Burgaz, A., Orsini, N., Larsson, S. C., & Wolk, A. (2011). Blood 25-hydroxyvitamin D concentration and hypertension: a meta-analysis. Journal of hypertension, 29(4), 636-645.
4. Gordan, R., Gwathmey, J. K., & Xie, L. H. (2015). Autonomic and endocrine control of cardiovascular function. World journal of cardiology, 7(4), 204.
5. Ceglia, L. (2009). Vitamin D and its role in skeletal muscle. Current opinion in clinical nutrition and metabolic care, 12(6), 628.
6. Bischoff-Ferrari, H. A., Dawson-Hughes, B., Willett, W. C., Staehelin, H. B., Bazemore, M. G., Zee, R. Y., & Wong, J. B. (2004). Effect of vitamin D on falls: a meta-analysis. Jama, 291(16), 1999-2006.
7. Cannell, J. J., Vieth, R., Umhau, J. C., Holick, M. F., Grant, W. B., Madronich, S., ... & Giovannucci, E. (2006). Epidemic influenza and vitamin D. Epidemiology & Infection, 134(6), 1129-1140.
8. Pilz, S., Frisch, S., Koertke, H., Kuhn, J., Dreier, J., Obermayer-Pietsch, B., ... & Zittermann, A. (2011). Effect of vitamin D supplementation on testosterone levels in men. Hormone and Metabolic Research, 43(3), 223.

Vitamin E

1. Brigelius-Flohe, R., & Traber, M. G. (1999). Vitamin E: function and metabolism. The FASEB Journal, 13(10), 1145-1155.
2. Herrera, E., & Barbas, C. (2001). Vitamin E: action, metabolism and perspectives. Journal of physiology and biochemistry, 57(1), 43-56.
3. Azzi, A., Ricciarelli, R., & Zingg, J. M. (2002). Non‐antioxidant molecular functions of α‐tocopherol (vitamin E). FEBS letters, 519(1-3), 8-10.

Thiamin

1. Weiss, S. (1940). Occidental Beriberi with Cardiovascular Manifestations: Its Relation to Thiamin Deficiency. Journal of the American Medical Association, 115(10), 832-839.
2. Collins, G. H. (1966). An electron microscopic study of remyelination in the brainstem of thiamin deficient rats. The American journal of pathology, 48(2), 259.
3. Wintrobe, M. M., Mitchell, D. M., & Kolb, L. C. (1938). Sensory Neuron Degeneration in Vitamin Deficiency: Degeneration of the Posterior Columns of the Spinal Cord, Peripheral Nerves, and Dorsal Root Ganglion Cells in Young Pigs Fed a Diet Containing Thiamin and Riboflavin but Otherwise Deficient in Vitamin B Complex. Journal of Experimental Medicine, 68(2), 207-220.
4. Muller, Y. A., Lindqvist, Y., Furey, W., Schulz, G. E., Jordan, F., & Schneider, G. (1993). A thiamin diphosphate binding fold revealed by comparison of the crystal structures of transketolase, pyruvate oxidase and pyruvate decarboxylase. Structure, 1(2), 95-103.

Riboflavin

1. Burch, H. B. (1957). ^[141] Fluorimetric assay of FAD, FMN, and riboflavin.
2. Lakshmi, R., Lakshmi, A. V., & Bamji, M. S. (1989). Skin wound healing in riboflavin deficiency. Biochemical medicine and metabolic biology, 42(3), 185-191.
3. Rushton, D. H. (2002). Nutritional factors and hair loss. Clinical and Experimental Dermatology: Clinical dermatology, 27(5), 396-404.
4. Cantaluppi, G. (1962). Clinico-experimental data on the use of riboflavin in the therapy of muscular cramps in pregnancy. Minerva ginecologica, 14, 984.
5. THOYER-ROZAT, J., BLANPIN, O., & PIERRE, R. (1962). Riboflavin in muscular cramp in pregnancy. Experimental and clinical study. Semaine des Hopitaux de Paris, 38(7).
6. Hassan, R. M., & Thurnham, D. I. (1977). Effect of riboflavin deficiency on the metabolism of the red blood cell. International journal for vitamin and nutrition research, 47(4), 349-355.

Niacin

1. Morris, B. J. (2013). Seven sirtuins for seven deadly diseases ofaging. Free Radical Biology and Medicine, 56, 133-171.
2. Hwang, E. S., & Song, S. B. (2017). Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells. Cellular and Molecular Life Sciences, 74(18), 3347-3362.
3. Jacobson, E. L., & Jacobson, M. K. (1997). ^[19] Tissue NAD as a biochemical measure of niacin status in humans. In Methods in enzymology(Vol. 280, pp. 221-230). Academic Press.
4. Malfait, P., Moren, A., Dillon, J. C., Brodel, A., Begkoyian, G., Etchegorry, M. G., ... & Hakewill, P. (1993). An outbreak of pellagra related to changes in dietary niacin among Mozambican refugees in Malawi. International Journal of Epidemiology, 22(3), 504-511.
5. Figueiredo, V. N., Vendrame, F., Colontoni, B. A., Quinaglia, T., Matos-Souza, J. R., Moura, F. A., ... & Sposito, A. C. (2014). Short-term effects of extended-release niacin with and without the addition of laropiprant on endothelial function in individuals with low HDL-C: a randomized, controlled crossover trial. Clinical therapeutics, 36(6), 961-966.

Vitamin B6

1. Denner, L. A., & Wu, J. Y. (1985). Two forms of rat brain glutamic acid decarboxylase differ in their dependence on free pyridoxal phosphate. Journal of neurochemistry, 44(3), 957-965.
2. Zhuo, J. M., & Praticò, D. (2010). Acceleration of brain amyloidosis in an Alzheimer’s disease mouse model by a folate, vitamin B6 and B12-deficient diet. Experimental gerontology, 45(3), 195-201.
3. RICHERT, D. A., & SCHULMAN, M. P. (1959). Vitamin interrelationships in heme synthesis. The American Journal of Clinical Nutrition, 7(4), 416-425.
4. Hedrick, J. L., & Fischer, E. H. (1965). On the Role of Pyridoxal 5'-Phosphate in Phosphorylase. I. Absence of Classical Vitamin B6—dependent Enzymatic Activities in Muscle Glycogen Phosphorylase. Biochemistry, 4(7), 1337-1343.
5. OKADA, M., ISHIKAWA, K., & WATANABE, K. (1991). Effect of vitamin B6 deficiency on glycogen metabolism in the skeletal muscle, heart, and liver of rats. Journal of nutritional science and vitaminology, 37(4), 349-357.

Vitamin B12

1. Woolf, K., & Manore, M. M. (2006). B-vitamins and exercise: does exercise alter requirements?. International journal of sport nutrition and exercise metabolism, 16(5), 453-484.
2. Paulin, F. V., Zagatto, A. M., Chiappa, G. R., & de Tarso Müller, P. (2017). Addition of vitamin B12 to exercise training improves cycle ergometer endurance in advanced COPD patients: A randomized and controlled study. Respiratory medicine, 122, 23-29.
3. Lukaski, H. C. (2004). Vitamin and mineral status: effects on physical performance. Nutrition, 20(7-8), 632-644.
4. Lövblad, K. O., Ramelli, G., Remonda, L., Nirkko, A. C., Ozdoba, C., & Schroth, G. (1997). Retardation of myelination due to dietary vitamin B 12 deficiency: cranial MRI findings. Pediatric radiology, 27(2), 155-158.
5. Pfohl-Leszkowicz, A., Keith, G., & Dirheimer, G. (1991). Effect of cobalamin derivatives on in vitro enzymic DNA methylation: methylcobalamin can act as a methyl donor. Biochemistry, 30(32), 8045-8051.

Biotin

1. Shiio, I., ÔTSUKA, S. I., & TAKAHASHI, M. (1962). Effect of biotin on the bacterial formation of glutamic acid: I. Glutamate formation and cellular permeability of amino acids. The Journal of Biochemistry, 51(1), 56-62.
2. Wang, Z. Q., Zhang, X. H., & Cefalu, W. T. (2000). Chromium picolinate and biotin enhance glycogen synthesis and glycogen synthase gene expression in human skeletal muscle culture. Diabetes Research and Clinical Practice, 50, 395.

Pantothenic Acid

1. Kelly, G. S. (1999). Nutritional and botanical interventions to assist with the adaptation to stress. Alternative medicine review: a journal of clinical therapeutic, 4(4), 249-265.
2. Evans, M., Rumberger, J. A., Azumano, I., Napolitano, J. J., Citrolo, D., & Kamiya, T. (2014). Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation. Vascular health and risk management, 10, 89.
3. Ralli, E. P., & Dumm, M. E. (1953). Relation of pantothenic acid to adrenal cortical function. Vitam Horm, 11, 133-158.

Vitamin K

1. Knapen, M. H. J., Schurgers, L. J., & Vermeer, C. (2007). Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporosis international, 18(7), 963-972.
2. Maresz, K. (2015). Proper calcium use: vitamin K2 as a promoter of bone and cardiovascular health. Integrative Medicine: A Clinician's Journal, 14(1), 34.
3. Huang, Z. B., Wan, S. L., Lu, Y. J., Ning, L., Liu, C., & Fan, S. W. (2015). Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporosis international, 26(3), 1175-1186.
4. Shea, M. K., Booth, S. L., Massaro, J. M., Jacques, P. F., D'Agostino Sr, R. B., Dawson-Hughes, B., ... & Vasan, R. S. (2007). Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study. American journal of epidemiology, 167(3), 313-320.
5. Hauschka, P. V., Lian, J. B., Cole, D. E., & Gundberg, C. M. (1989). Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone. Physiological reviews, 69(3), 990-1047.

Folic Acid

1. Welzel, T. M., Katki, H. A., Sakoda, L. C., Evans, A. A., London, W. T., Chen, G., ... & McGlynn, K. A. (2007). Blood folate levels and risk of liver damage and hepatocellular carcinoma in a prospective high-risk cohort. Cancer Epidemiology and Prevention Biomarkers, 16(6), 1279-1282.
2. Shrubsole, M. J., Jin, F., Dai, Q., Shu, X. O., Potter, J. D., Hebert, J. R., ... & Zheng, W. (2001). Dietary folate intake and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer research, 61(19), 7136-7141.
3. Su, L. J., & Arab, L. (2001). Nutritional status of folate and colon cancer risk: evidence from NHANES I epidemiologic follow-up study. Annals of epidemiology, 11(1), 65-72.
4. Wilson, R. D., Désilets, V., Wyatt, P., Langlois, S., Gagnon, A., Allen, V., ... & Koren, G. (2007). Pre-conceptional vitamin/folic acid supplementation 2007: the use of folic acid in combination with a multivitamin supplement for the prevention of neural tube defects and other congenital anomalies. Journal of obstetrics and gynaecology Canada, 29(12), 1003-1013.

Boron

1. Pizzorno, L. (2015). Nothing boring about boron. Integrative Medicine: A Clinician's Journal, 14(4), 35.
2. Naghii, M. R. (1999). The significance of dietary boron, with particular reference to athletes. Nutrition and health, 13(1), 31-37.
3. Nielsen FH, Stoecker BJ. (2009) Boron and fish oil have different beneficial effects on strength and trabecular microarchitecture of bone. J Trace Elem Med Biol.23(3):195–203
4. Dupre, J. N., Keenan, M. J., Hegsted, M., & Brudevold, A. M. (1994). Effects of dietary boron in rats fed a vitamin D-deficient diet. Environmental health perspectives, 102(Suppl 7), 55.

Calcium

1. Johnston Jr, C. C., Miller, J. Z., Slemenda, C. W., Reister, T. K., Hui, S., Christian, J. C., & Peacock, M. (1992). Calcium supplementation and increases in bone mineral density in children. New England journal of medicine, 327(2), 82-87.
2. Reid, I. R., Ames, R. W., Evans, M. C., Gamble, G. D., & Sharpe, S. J. (1995). Long-term effects of calcium supplementation on bone loss and fractures in postmenopausal women: a randomized controlled trial. The American journal of medicine, 98(4), 331-335.
3. Ebashi, S., & Endo, M. (1968). Calcium and muscle contraction. Progress in biophysics and molecular biology, 18, 123-183.

Phosphorus

1. Teegarden, D., Lyle, R. M., McCabe, G. P., McCabe, L. D., Proulx, W. R., Michon, K., ... & Weaver, C. M. (1998). Dietary calcium, protein, and phosphorus are related to bone mineral density and content in young women. The American journal of clinical nutrition, 68(3), 749-754.

Iodine

1. Liu, Y., Zhang, L., Li, J., Shan, Z., & Teng, W. (2013). Effects of Marginal Iodine Deficiency on rat offspring. Journal of Endocrinology, JOE-12.
2. Sethi, V., & Kapil, U. (2004). Iodine deficiency and development of brain. The Indian Journal of Pediatrics, 71(4), 325-329.
3. Zimmermann, M. B., & Galetti, V. (2015). Iodine intake as a risk factor for thyroid cancer: a comprehensive review of animal and human studies. Thyroid research, 8(1), 8.
4. Abrams, G. M., & Larsen, P. R. (1973). Triiodothyronine and thyroxine in the serum and thyroid glands of iodine-deficient rats. The Journal of clinical investigation, 52(10), 2522-2531.

Magnesium

1. Food and Nutrition Board. (1997). Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D and floride. Washington, DC: National Academy Press; 1997
2. Volpe, S. L. (2015). Magnesium and the athlete. Current sports medicine reports, 14(4), 279-283.
3. McDonald, R., & Keen, C. L. (1988). Iron, zinc and magnesium nutrition and athletic performance. Sports Medicine, 5(3), 171-184.
4. Lukaski, H. C., & Nielsen, F. H. (2002). Dietary magnesium depletion affects metabolic responses during submaximal exercise in postmenopausal women. The Journal of nutrition, 132(5), 930-935.
5. Vecchiet, L., Pieralisi, G., D’Ovidio, M., Dragani, L., Felzani, G., Mincarini, A., ... & Piovanelli, P. (1995). Effects of magnesium supplementation on maximal and submaximal effort. Magnesium and Physical Activity, 227-237.
6. Brilla, L. R., & Gunther, K. B. (1995). Effect of magnesium supplementation on exercise time to exhaustion. Med Exerc Nutr Health, 4, 230-233.

Zinc

1. Kilic, M., Baltaci, A. K., Gunay, M., Gökbel, H., Okudan, N., & Cicioglu, I. (2006). The effect of exhaustion exercise on thyroid hormones and testosterone levels of elite athletes receiving oral zinc. Neuro endocrinology letters, 27(1-2), 247-252.
2. Masayoshi, Y., Masatsugu, K., & Shoji, O. (1982). Role of zinc as an activator of mitochondrial function in rat liver. Biochemical pharmacology, 31(7), 1289-1293.
3. Xu, Z., & Zhou, J. (2013). Zinc and myocardial ischemia/reperfusion injury. Biometals, 26(6), 863-878.
4. Eby, G. A., & Halcomb, W. W. (2006). High-dose zinc to terminate angina pectoris: a review and hypothesis for action by ICAM inhibition. Medical hypotheses, 66(1), 169-172.
5. Guoa, C. H., Wangb, C. L., Chen, P. C., & Yang, T. C. (2011). Linkage of some trace elements, peripheral blood lymphocytes, inflammation, and oxidative stress in patients undergoing either hemodialysis or peritoneal dialysis. Peritoneal Dialysis International, 31(5), 583-591.
6. Mocchegiani, E., Costarelli, L., Giacconi, R., Cipriano, C., Muti, E., & Malavolta, M. (2006). Zinc-binding proteins (metallothionein and α-2 macroglobulin) and immunosenescence. Experimental gerontology, 41(11), 1094-1107.
7. Kordas, K., Siegel, E. H., Olney, D. K., Katz, J., Tielsch, J. M., Kariger, P. K., ... & Stoltzfus, R. J. (2009). The effects of iron and/or zinc supplementation on maternal reports of sleep in infants from Nepal and Zanzibar. Journal of developmental and behavioral pediatrics: JDBP, 30(2), 131.
8. Song, C. H., Kim, Y. H., & Jung, K. I. (2012). Associations of zinc and copper levels in serum and hair with sleep duration in adult women. Biological trace element research, 149(1), 16-21.

Selenium

1. Stapleton, S. R. (2000). Selenium: an insulin mimetic. Cellular and Molecular Life Sciences CMLS, 57(13-14), 1874-1879.
2. Drutel, A., Archambeaud, F., & Caron, P. (2013). Selenium and the thyroid gland: more good news for clinicians. Clinical endocrinology, 78(2), 155-164.
3. Toulis, K. A., Anastasilakis, A. D., Tzellos, T. G., Goulis, D. G., & Kouvelas, D. (2010). Selenium supplementation in the treatment of Hashimoto's thyroiditis: a systematic review and a meta-analysis. Thyroid, 20(10), 1163-1173.
4. Behne, D., Weiler, H., & Kyriakopoulos, A. (1996). Effects of selenium deficiency on testicular morphology and function in rats. Journal of reproduction and fertility, 106(2), 291-297.
5. Maggio, M., De Vita, F., Lauretani, F., Buttò, V., Bondi, G., Cattabiani, C., ... & Ceda, G. P. (2013). IGF-1, the cross road of the nutritional, inflammatory and hormonal pathways to frailty. Nutrients, 5(10), 4184-4205.
6. El-Sisy, G. A., Abdel-Razek, A. M. A., Younis, A. A., Ghallab, A. M., & Abdou, M. S. S. (2008). Effect of dietary zinc or Selenium supplementation on some reproductive hormone levels in male Baladi Goats. Global Vet, 2(2), 46-50.
7. Neek, L. S., Gaeini, A. A., & Choobineh, S. (2011). Effect of zinc and selenium supplementation on serum testosterone and plasma lactate in cyclist after an exhaustive exercise bout. Biological trace element research, 144(1-3), 454-462.

Copper

1. House, E., Mold, M., Collingwood, J., Baldwin, A., Goodwin, S., & Exley, C. (2009). Copper abolishes the β-sheet secondary structure of preformed amyloid fibrils of amyloid-β 42. Journal of Alzheimer's Disease, 18(4), 811-817.
2. Kashanian, M., Hadizadeh, H., Faghankhani, M., Nazemi, M., & Sheikhansari, N. (2018). Evaluating the effects of copper supplement during pregnancy on premature rupture of membranes and pregnancy outcome. The Journal of Maternal-Fetal & Neonatal Medicine, 31(1), 39-46.
3. Al-Bayati, M. A., Jamil, D. A., & Al-Aubaidy, H. A. (2015). Cardiovascular effects of copper deficiency on activity of superoxide dismutase in diabetic nephropathy. North American journal of medical sciences, 7(2), 41.
4. Allen, K. G., & Klevay, L. M. (1978). Cholesterolemia and cardiovascular abnormalities in rats caused by copper deficiency. Atherosclerosis, 29(1), 81-93.

Manganese

1. Leach RM, Harris ED. Manganese. In: O'Dell BL, Sunde RA, eds. Handbook of nutritionally essential minerals. New York: Marcel Dekker, Inc; 1997:335-355
2. Liu, A. H., Heinrichs, B. S., & Leach Jr, R. M. (1994). Influence of manganese deficiency on the characteristics of proteoglycans of avian epiphyseal growth plate cartilage. Poultry science, 73(5), 663-669.
3. Zhao, Y., Chaiswing, L., Velez, J. M., Batinic-Haberle, I., Colburn, N. H., Oberley, T. D., & Clair, D. K. S. (2005). p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase. Cancer research, 65(9), 3745-3750.
4. Bock, C. W., Katz, A. K., Markham, G. D., & Glusker, J. P. (1999). Manganese as a replacement for magnesium and zinc: functional comparison of the divalent ions. Journal of the American Chemical Society, 121(32), 7360-7372.
5. Wedler, F. C., Denman, R. B., & Roby, W. G. (1982). Glutamine synthetase from ovine brain is a manganese (II) enzyme. Biochemistry, 21(25), 6389-6396.

Chromium

1. Mertz, W. (1993). Chromium in human nutrition: a review. The Journal of nutrition, 123(4), 626-633.
2. Pechova, A., & Pavlata, L. (2007). Chromium as an essential nutrient: a review. VETERINARNI MEDICINA-PRAHA-, 52(1), 1.

Fruits & Greens

1. Wang, X., Ouyang, Y., Liu, J., Zhu, M., Zhao, G., Bao, W., & Hu, F. B. (2014). Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies. Bmj, 349, g4490.
2. John, J. H., Ziebland, S., Yudkin, P., Roe, L. S., & Neil, H. A. W. (2002). Effects of fruit and vegetable consumption on plasma antioxidant concentrations and blood pressure: a randomised controlled trial. The lancet, 359(9322), 1969-1974.
3. Beecher, G. R. (1999). Phytonutrients' role in metabolism: effects on resistance to degenerative processes. Nutrition Reviews, 57(9), 3-6.

MSM

1. Debbi, E. M., Agar, G., Fichman, G., Ziv, Y. B., Kardosh, R., Halperin, N., ... & Debi, R. (2011). Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC complementary and alternative medicine, 11(1), 50.
2. Barmaki, S., Bohlooli, S., Khoshkhahesh, F., & Nakhostin-Roohi, B. (2012). Effect of methylsulfonylmethane supplementation on exercise—Induced muscle damage and total antioxidant capacity. Journal of Sports Medicine and Physical Fitness, 52(2), 170.
3. Nakhostin‐Roohi, B., Barmaki, S., Khoshkhahesh, F., & Bohlooli, S. (2011). Effect of chronic supplementation with methylsulfonylmethane on oxidative stress following acute exercise in untrained healthy men. Journal of Pharmacy and Pharmacology, 63(10), 1290-1294.

Green Tea

1. Maki, K. C., Reeves, M. S., Farmer, M., Yasunaga, K., Matsuo, N., Katsuragi, Y., ... & Blumberg, J. B. (2008). Green tea catechin consumption enhances exercise-induced abdominal fat loss in overweight and obese adults. The Journal of nutrition, 139(2), 264-270.
2. Wang, H., Wen, Y., Du, Y., Yan, X., Guo, H., Rycroft, J. A., ... & Mela, D. J. (2010). Effects of catechin enriched green tea on body composition. Obesity, 18(4), 773-779.
3. Venables, M. C., Hulston, C. J., Cox, H. R., & Jeukendrup, A. E. (2008). Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans. The American journal of clinical nutrition, 87(3), 778-784.
4. Wu, A. H., Spicer, D., Stanczyk, F. Z., Tseng, C., Yang, C. S., & Pike, M. C. (2012). Effect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormonal levels in healthy postmenopausal women. Cancer Prevention Research, canprevres-0407.
5. Batista, G. D. A. P., Cunha, C. L., Scartezini, M., von der Heyde, R., Bitencourt, M. G., & Melo, S. F. D. (2009). Prospective double-blind crossover study of Camellia sinensis (green tea) in dyslipidemias. Arquivos brasileiros de cardiologia, 93(2), 128-134.

Alpha-Lipoic Acid

1. Zembron-Lacny, A., Slowinska-Lisowska, M., Szygula, Z., Witkowski, K., Stefaniak, T., & Dziubek, W. (2009). Assessment of the antioxidant effectiveness of alpha-lipoic acid in healthy men exposed to muscle-damaging exercise. J Physiol Pharmacol, 60(2), 139-43.
2. Xiang, G. D., Pu, J. H., Sun, H. L., & Zhao, L. S. (2010). Alpha-lipoic acid improves endothelial dysfunction in patients with subclinical hypothyroidism. Experimental and clinical endocrinology & diabetes, 118(09), 625-629.
3. Ranieri, M., Sciuscio, M., Cortese, A. M., Santamato, A., Di Teo, L., Ianieri, G., ... & Megna, M. (2009). The Use and Alpha-Lipoic Acid (ALA), Gamma Linolenic Acid (GLA) and Rehabilitation in the Treatment of Back Pain: Effect on Health-Related Quality of Life. International journal of immunopathology and pharmacology, 22(3_suppl), 45-50.

Coenzyme Q10

1. Glover, E. I., Martin, J., Maher, A., Thornhill, R. E., Moran, G. R., & Tarnopolsky, M. A. (2010). A randomized trial of coenzyme Q10 in mitochondrial disorders. Muscle & nerve, 42(5), 739-748.
2. Liao, P., Zhang, Y., Liao, Y., Zheng, N. J., & Zhang, X. (2007). Effects of coenzyme Q10 supplementation on liver mitochondrial function and aerobic capacity in adolescent athletes. Chinese journal of applied physiology, 23(4), 491-494.
3. Alehagen, U., Aaseth, J., Alexander, J., & Johansson, P. (2018). Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly. PloS one, 13(4), e0193120.

Pycnogenol

1. Belcaro, G., Luzzi, R., Dugall, M., Ippolito, E., & Saggino, A. (2014). Pycnogenol improves cognitive function, attention, mental performance and specific professional skills in healthy professionals age 35–55. J Neurosurg Sci, 58(4), 239-248.
2. Belcaro, G., Cesarone, M. R., Steigerwalt, R. J., Di, A. R., Grossi, M. G., Ricci, A., ... & Cacchio, M. (2008). Jet-lag: prevention with Pycnogenol. Preliminary report: evaluation in healthy individuals and in hypertensive patients. Minerva cardioangiologica, 56(5 Suppl), 3-9.
3. Marini, A., Grether-Beck, S., Jaenicke, T., Weber, M., Burki, C., Formann, P., ... & Krutmann, J. (2012). Pycnogenol effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women. Skin pharmacology and physiology, 25(2), 86-92.
4. Devaraj, S., Vega-López, S., Kaul, N., Schönlau, F., Rohdewald, P., & Jialal, I. (2002). Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids, 37(10), 931-934.
5. Koch, R. (2002). Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency. Phytotherapy Research, 16(S1), 1-5.
6. Enseleit, F., Sudano, I., Periat, D., Winnik, S., Wolfrum, M., Flammer, A. J., ... & Krasniqi, N. (2012). Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study. European heart journal, 33(13), 1589-1597.
7. Nishioka, K., Hidaka, T., Nakamura, S., Umemura, T., Jitsuiki, D., Soga, J., ... & Higashi, Y. (2007). Pycnogenol, French maritime pine bark extract, augments endothelium-dependent vasodilation in humans. Hypertension Research, 30(9), 775.
8. Luzzi, R., Belcaro, G., Zulli, C., Cesarone, M. R., Cornelli, U., Dugall, M., ... & Feragalli, B. (2011). Pycnogenol supplementation improves cognitive function, attention and mental performance in students. Panminerva medica, 53(3 Suppl 1), 75-82.

Grape Seed Extract

1. Kijima, I., Phung, S., Hur, G., Kwok, S. L., & Chen, S. (2006). Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer research, 66(11), 5960-5967.
2. Vogels, N., Nijs, I. M. T., & Westerterp-Plantenga, M. S. (2004). The effect of grape-seed extract on 24 h energy intake in humans. European journal of clinical nutrition, 58(4), 667.
3. Clifton, P. M. (2004). Effect of grape seed extract and quercetin on cardiovascular and endothelial parameters in high-risk subjects. BioMed Research International, 2004(5), 272-278.
4. Kar, P., Laight, D., Rooprai, H. K., Shaw, K. M., & Cummings, M. (2009). Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabetic Medicine, 26(5), 526-531.

Saw Palmetto Extract

1. Bertaccini, A., Giampaoli, M., Cividini, R., Gattoni, G. L., Sanseverino, R., Realfonso, T., ... & Galasso, R. (2012). Observational database serenoa repens (DOSSER): overview, analysis and results. A multicentric SIUrO (Italian Society of Oncological Urology) project. Archivio italiano di urologia, andrologia: organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica, 84(3), 117-122.
2. Suter, A., Saller, R., Riedi, E., & Heinrich, M. (2013). Improving BPH symptoms and sexual dysfunctions with a saw palmetto preparation? Results from a pilot trial. Phytotherapy research, 27(2), 218-226.
3. Rossi, A., Mari, E., Scarno, M., Garelli, V., Maxia, C., Scali, E., ... & Carlesimo, M. (2012). Comparitive Effectiveness and Finasteride Vs Serenoa Repens in Male Androgenetic Alopecia: A Two-Year Study. International journal of immunopathology and pharmacology, 25(4), 1167-1173.

Lutein

1. Nidhi, B., Sharavana, G., Ramaprasad, T. R., & Vallikannan, B. (2015). Lutein derived fragments exhibit higher antioxidant and anti-inflammatory properties than lutein in lipopolysaccharide induced inflammation in rats. Food & function, 6(2), 450-460.
2. Dagnelie, G., Zorge, I. S., & McDonald, T. M. (2000). Lutein improves visual function in some patients with retinal degeneration: a pilot study via the Internet. Optometry (St. Louis, Mo.), 71(3), 147-164.
3. Mares-Perlman, J. A., Millen, A. E., Ficek, T. L., & Hankinson, S. E. (2002). The body of evidence to support a protective role for lutein and zeaxanthin in delaying chronic disease. Overview. The Journal of nutrition, 132(3), 518S-524S.

Piperine

1. Shoba₁, G., Joy₁, D., Joseph₁, T., Rajendran₂, M. M. R., & Srinivas₂, P. S. S. R. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta medica, 64, 353-356.
2. Han, H. K. (2011). The effects of black pepper on the intestinal absorption and hepatic metabolism of drugs. Expert opinion on drug metabolism & toxicology, 7(6), 721-729.

Advanced Enzyme Blend (protease, amylase, lipase, cellulose lactase, betaine)

1. Lami, F., Callegari, C., Tatali, M., Graziano, L., Guidetti, C., Miglioli, M., & Barbara, L. (1988). Efficacy of addition of exogenous lactase to milk in adult lactase deficiency. American Journal of Gastroenterology, 83(10).

WARNING

California’s Proposition 65 entitles California consumers to special warnings.

WARNING: Cancer and Reproductive Harm -www.P65warnings.ca.gov/