Synergy Overview
Mitochondrial Biogenesis & Cellular Energy: Alpha Lipoic Acid (ALA), PQQ, CoQ10, and MitoPrime form the core of the formula’s mitochondrial support system. ALA and CoQ10 work within the electron transport chain to enhance ATP output, while PQQ triggers mitochondrial biogenesis through PGC-1α activation. MitoPrime (ergothioneine) uniquely accumulates in mitochondria and long-lived cells, scavenging reactive oxygen species and preventing mitochondrial DNA damage. Together, this quartet sustains cellular energy and resilience under oxidative stress.
Liver Detoxification & Cytoprotection: N-Acetyl L-Cysteine (NAC), Milk Thistle (silymarin), Oleano 35 (oleanolic acid), and ALA synergize to protect hepatocytes and promote glutathione synthesis. NAC and Milk Thistle enhance intracellular antioxidant capacity, while Oleano 35 upregulates detoxification enzymes and reduces hepatic fat accumulation. Curcumin and Berberine add anti-inflammatory and lipid-modulating support, rounding out a robust hepatic defense network.
Cardiovascular Health & Endothelial Function: Citrus Bergamot, Arjuna, Grape Seed Extract, and CoQ10 work in harmony to support blood vessel tone, cholesterol balance, and nitric oxide signaling. Arjuna and Bergamot help modulate blood lipids and support left ventricular function, while grape seed polyphenols improve microvascular integrity. CoQ10 enhances endothelial energy supply and resilience. Combined, they offer comprehensive vascular protection and heart health optimization.
Metabolic Regulation & Glucose Control: Berberine, ALA, Citrus Bergamot, and Oleano 35 all converge on metabolic pathways to improve glucose handling and insulin sensitivity. Berberine activates AMPK and modulates gut microbiota, while ALA supports insulin signaling and glucose oxidation. Citrus Bergamot complements these effects with its impact on triglycerides and fatty acid metabolism. This metabolic synergy may help support healthy blood sugar levels and body composition.
Nutrient Absorption & Bioavailability Enhancement: AstraGin and BioPerine play complementary roles in enhancing nutrient uptake. AstraGin increases transporter expression in the gut, improving amino acid and polyphenol absorption, while BioPerine inhibits metabolizing enzymes and boosts bioavailability of curcumin, CoQ10, and Berberine. Their combined action ensures the full potency of the formula is realized at the cellular level.
Oxidative Stress Defense & Inflammatory Modulation: Curcumin, NAC, ALA, Grape Seed, and Milk Thistle form a high-impact antioxidant matrix targeting free radicals, lipid peroxidation, and inflammatory cytokines. PQQ and MitoPrime reinforce this network at the mitochondrial and genomic levels, providing protection where oxidative damage originates. These compounds also modulate Nrf2 and NF-κB signaling, contributing to whole-body anti-inflammatory effects.
FAQ
Q: What’s the main shift in this new formula?
A: The new version has evolved into a full-body health and resilience stack, supporting:
- Organ detox + function (liver, heart, kidneys)
- Blood sugar + lipid balance
- Mitochondrial and antioxidant defense
- Cardiovascular flow + endothelial health
- Cellular longevity + gene expression
- Biomarker optimization (AST, ALT, CRP, GGT, triglycerides, LDL, etc.)
This is no longer just organ support, it’s whole-body internal optimization.
Q: What were the biggest upgrades or additions?
New Key Additions:
- Alpha Lipoic Acid (600 mg) – systemic antioxidant, insulin sensitivity, liver enzyme regulation
- Berberine HCl (500 mg) – blood glucose, lipid profile, gut-liver axis
- Oleanolic Acid (250 mg) – hepatoprotective and anti-inflammatory
- PQQ (20 mg) – mitochondrial biogenesis and neurovascular health
- MitoPrime L-Ergothioneine (5 mg) – rare amino acid antioxidant for cellular repair
- Grape Seed Extract (95% OPC, now 200 mg) – vascular integrity + anti-inflammatory
- BioPerine reduced from 20 mg → 5 mg for better tolerance
Q: What ingredients stayed and still deliver clinical value?
Retained from Old Formula:
- NAC (600 mg) – glutathione precursor, liver detox
- Arjuna (500 mg) – cardiovascular and liver perfusion support
- Citrus Bergamot (500 mg) – cholesterol, inflammation, fatty liver support
- Turmeric (500 mg, 95%) – anti-inflammatory, liver enzyme and bile regulation
- Milk Thistle (250 mg, 80% silymarin) – liver repair and cell regeneration
- CoQ10 (50 mg) – mitochondrial + cardiovascular energy
- AstraGin (50 mg) – enhances uptake of amino acids and plant bioactives
Q: What ingredients were removed and why?
Removed or Reduced:
- CardioAid Plant Sterols (800 mg) – replaced by multi-system metabolic support; added to the new HEART + LIPIDS
- Red Yeast Rice (600 mg) – moved to the new HEART + LIPIDS
- High-dose BioPerine (20 mg) – reduced for improved GI tolerance as well as easier stacking with other products containing BioPerine
These changes reflect a move to multi-pathway organ and metabolic protection product.
A: Yes, the new formula can help support improvement in:
- Liver enzymes (ALT, AST, ALP, GGT) — NAC, ALA, milk thistle, turmeric
- Cholesterol + triglycerides — berberine, bergamot, grape seed
- Inflammation markers (e.g. CRP) — curcumin, ALA, PQQ, MitoPrime
- Fasting glucose + A1C — berberine, ALA, CoQ10
- Kidney markers + bile flow — oleanolic acid, arjuna, grape seed
Q: How do I take it?
A:
- Consume six (6) capsules daily, all together or spaced apart
- Best Timing: Spaced apart, with your largest meals (for absorption of fat-soluble actives)
- Hydration: Essential for detox and liver/kidney support
- Stacks With: MULTI, OMEGA, or HEALTH Series product
- Cycle: No cycling needed; designed for long-term, daily use
Q: Who should take this?
A:
- Anyone looking to optimize internal health, organs, and lab values
- Individuals under high physiological or toxic load
- Athletes using supplements, PEDs, or high-protein diets
- People focused on longevity, inflammation control, and aging biomarkers
- Anyone concerned with cholesterol, blood sugar, or liver function
