Morphogen Nutrition PRIME - Total Health

PRIME: TOTAL HEALTH

Organ Health • Blood Work Support • Longevity

PRIME is your advanced internal health formula designed to optimize organ function, support clean blood work, and promote long-term cellular vitality. With ingredients like NAC, Citrus Bergamot, Curcumin, Milk Thistle, and CoQ10, it covers heart, liver, metabolic, and oxidative stress pathways in one high-impact blend.

Key Benefits:

• Supports liver, kidney, cardiovascular, and metabolic health
  

• Promotes healthy blood sugar, lipids, and inflammatory markers
  

• Enhances antioxidant capacity and cellular defense
  

• Built for longevity and full-body internal support
  

Alpha Lipoic Acid (ALA) – 600 mg

ALA is a potent antioxidant involved in mitochondrial energy metabolism and redox regulation.

• Supports healthy glucose metabolism and insulin sensitivity
• Enhances mitochondrial energy production and ATP synthesis
• Reduces oxidative stress and regenerates other antioxidants like vitamins C and E
• Supports liver detoxification and neuroprotection

Synergy: Pairs with NAC and PQQ to enhance mitochondrial resilience and redox cycling.

• Shay KP et al. Free Radic Biol Med. 2009;46(1):117–128.
• Ghibu S et al. Curr Drug Metab. 2009;10(2):164–174.
• Zhang WJ, Frei B. J Nutr Biochem. 2007;18(7):475–484.
• Wollin SD, Jones PJ. J Clin Biochem Nutr. 2003;33(3):119–130.

N-Acetyl L-Cysteine (NAC) – 600 mg

NAC is a precursor to glutathione, a major intracellular antioxidant.

• Boosts glutathione synthesis for cellular detoxification
• Protects the liver from toxins and heavy metals
• Helps reduce inflammation and oxidative damage
• Supports immune modulation and respiratory health

Synergy: Enhances antioxidant defense when combined with ALA and milk thistle.

• Aldini G et al. Free Radic Res. 2018;52(7):751–762.
• Rushworth GF, Megson IL. Pharmacol Ther. 2014;141(2):150–159.
• Samuni Y et al. Biochim Biophys Acta. 2013;1830(10):4117–4129.
• Millea PJ. Am Fam Physician. 2009;80(3):265–269.

Arjuna Extract (Terminalia arjuna, std. 20% polyphenols) – 500 mg

What it is: A bark extract used in Ayurvedic medicine for cardiovascular and antioxidant support.

• Promotes heart function and healthy blood pressure
• Reduces markers of cardiac oxidative stress and inflammation
• May help modulate lipid profiles
• Protects vascular endothelium

Synergy: Works with grape seed and bergamot to promote cardiovascular resilience.

• Bharani A et al. Int J Cardiol. 1995;49(3):191–199.
• Dwivedi S. J Ethnopharmacol. 2007;114(2):114–129.
• Panda S et al. J Tradit Complement Med. 2014;4(4):224–231.
• Sharma R. Altern Med Rev. 1999;4(6):436–446.

Berberine HCl (Berberis aristata, bark) – 500 mg

What it is: A bioactive alkaloid known for metabolic and lipid regulatory properties.

• Helps reduce blood glucose and insulin resistance
• Supports lipid metabolism and healthy cholesterol levels
• Promotes gut microbiota balance
• Activates AMPK for metabolic regulation

Synergy: Amplifies metabolic effects of ALA and Citrus Bergamot.

• Zhang Y et al. Metabolism. 2008;57(5):712–717.
• Kong WJ et al. Nat Med. 2004;10(12):1344–1351.
• Cicero AFG et al. Phytomedicine. 2020;67:153135.
• Brusq JM et al. Biochem Pharmacol. 2006;71(7):1056–1067.

Citrus Bergamot Extract (5:1) – 500 mg

What it is: A polyphenol-rich extract from bergamot oranges, used for cardiovascular and metabolic support.

• Supports cholesterol management and triglyceride reduction
• Helps maintain healthy blood glucose levels
• Provides antioxidant and anti-inflammatory properties
• Supports endothelial function and nitric oxide production

Synergy: Complements Arjuna and Berberine in cardiovascular protection.

• Mollace V et al. Fitoterapia. 2011;82(3):309–316.
• Gliozzi M et al. Crit Rev Food Sci Nutr. 2016;56(4):606–621.
• Miceli N et al. Fitoterapia. 2007;78(6):454–462.
• Di Donna L et al. J Nat Prod. 2009;72(7):1352–1364.

Curcumin (from Turmeric, std. 95% curcuminoids) – 500 mg

A bioactive polyphenol from turmeric root with antioxidant and anti-inflammatory effects.

• Inhibits NF-κB and inflammatory cytokines
• Protects liver and cardiovascular tissues
• Modulates oxidative stress pathways
• Supports healthy lipid and glucose levels

Synergy: Enhanced by piperine and milk thistle for absorption and liver support.

• Aggarwal BB, Harikumar KB. Int J Biochem Cell Biol. 2009;41(1):40–59.
• Gupta SC et al. Biofactors. 2013;39(1):20–55.
• Panahi Y et al. Phytother Res. 2014;28(4):514–520.
• Anand P et al. Mol Pharm. 2007;4(6):807–818.

Oleano 35 Oleanolic Acid (35% from Olive Fruit) – 250 mg

A pentacyclic triterpenoid from olives that supports metabolic and liver health.

• Supports hepatic detoxification enzymes
• Reduces liver fat and improves insulin sensitivity
• Protects against oxidative damage
• Helps modulate lipid and glucose metabolism

Synergy: Complements NAC, ALA, and Berberine in liver defense.

• Liu J. J Ethnopharmacol. 1995;49(2):57–68.
• Rodriguez-Rodriguez R et al. Mol Nutr Food Res. 2010;54(10):1340–1351.
• Reyes-Zurita FJ et al. J Agric Food Chem. 2009;57(20):9328–9334.
• Santos J et al. J Funct Foods. 2012;4(3):793–803.

Milk Thistle Extract (Silybum marianum, min. 80% silymarin) – 250 mg

A flavonoid complex known for hepatoprotective and antioxidant effects.

• Enhances liver detoxification and glutathione levels
• Protects hepatocytes from toxins and inflammation
• Regenerates damaged liver cells
• Antioxidant and anti-fibrotic properties

Synergy: Works synergistically with NAC, Curcumin, and Oleano 35 for liver protection.

• Saller R et al. Am J Med. 2008;104(3):261–266.
• Pradhan SC, Girish C. Indian J Med Res. 2006;124(5):491–504.
• Abenavoli L et al. Phytother Res. 2010;24(10):1423–1432.
• Polyak SJ et al. Hepatology. 2007;45(2):420–429.

Grape Seed Extract (Vitis vinifera, std. 95% proanthocyanidins) – 200 mg

A polyphenol-rich antioxidant known for vascular, metabolic, and anti-inflammatory benefits.

• Supports vascular elasticity and endothelial function
• Reduces oxidative stress and LDL oxidation
• Modulates blood pressure and inflammatory cytokines
• Enhances capillary strength and microcirculation

Synergy: Reinforces Arjuna and Bergamot in vascular support.

• Terra X et al. Br J Nutr. 2009;102(2):227–234.
• Bagchi D et al. Mutat Res. 2000;523–524:87–97.
• Sivaprakasapillai B et al. J Am Coll Nutr. 2009;28(3):266–272.
• Forester SC, Waterhouse AL. J Nutr Biochem. 2009;20(7):491–502.

AstraGin (Panax notoginseng & Astragalus membranaceus) – 50 mg

A patented blend shown to enhance nutrient absorption.

• Improves absorption of amino acids, vitamins, and polyphenols
• Supports gut barrier integrity and microbiome diversity
• May enhance bioavailability of adaptogens and antioxidants
• Reduces gut inflammation

Synergy: Improves uptake of Curcumin, Berberine, and PQQ.

• Singh A et al. J Agric Food Chem. 2015;63(30):6921–6928.
• He L et al. J Ethnopharmacol. 2012;139(3):701–706.
• AstraGin Internal Study Reports. NuLiv Science.
• Wang D et al. Fitoterapia. 2013;84:109–117.

Coenzyme Q10 (Ubiquinone) – 50 mg

A fat-soluble compound crucial for mitochondrial ATP synthesis and antioxidant defense.

• Supports energy production in the electron transport chain
• Protects mitochondria from oxidative stress
• Helps maintain cardiovascular function
• Reduces statin-induced myopathy risk

Synergy: Functions synergistically with PQQ and ALA in mitochondrial protection.

• Littarru GP, Tiano L. Biofactors. 2007;32(1–4):129–133.
• Mortensen SA et al. JACC Heart Fail. 2014;2(6):641–649.
• Crane FL. J Am Coll Nutr. 2001;20(6):591–598.
• Hernández-Camacho JD et al. Antioxidants. 2020;9(5):513.

Pyrroloquinoline Quinone Disodium Salt (PQQ) – 20 mg

A redox cofactor that promotes mitochondrial biogenesis and antioxidant activity.

• Stimulates growth of new mitochondria (PGC-1α activation)
• Reduces markers of oxidative stress and inflammation
• Improves cognitive and cardiovascular function
• Enhances energy production efficiency

Synergy: Complements CoQ10 and ALA in mitochondrial synergy.

• Stites TE et al. J Nutr. 2006;136(2):390–396.
• Rucker R. Altern Med Rev. 2009;14(3):268–277.
• Chowanadisai W et al. J Biol Chem. 2010;285(1):142–152.
• Nakano M et al. Biosci Biotechnol Biochem. 2012;76(6):1095–1101.

BioPerine (Black Pepper Extract, 95% Piperine) – 5 mg

A standardized black pepper extract known for enhancing nutrient bioavailability.

• Increases absorption of curcumin, CoQ10, and other polyphenols
• Inhibits drug-metabolizing enzymes (CYP450, P-gp)
• Boosts thermogenesis and digestion
• May improve bioavailability of fat-soluble nutrients

Synergy: Enhances Curcumin, CoQ10, and Berberine absorption.

• Shoba G et al. Planta Med. 1998;64(4):353–356.
• Lambert JD et al. J Nutr. 2004;134(12):3211–3216.
• Srinivasan K. Crit Rev Food Sci Nutr. 2007;47(8):735–748.
• Atal CK et al. J Ethnopharmacol. 1985;11(3):293–306.

MitoPrime (L-Ergothioneine 98%) – 5 mg

A rare antioxidant amino acid known for cellular protection and mitochondrial defense.

• Concentrated in mitochondria and long-lived cells
• Protects DNA, proteins, and lipids from oxidative damage
• Acts as a cytoprotectant in high-stress environments
• Supports brain, liver, and cardiovascular health

Synergy: Enhances the cellular defense network with CoQ10, ALA, and PQQ.

• Cheah IK et al. Biochim Biophys Acta. 2016;1860(11 Pt A):2684–2699.
• Ames BN. Proc Natl Acad Sci U S A. 2018;115(52):13355–13357.
• Gründemann D. Biochem Pharmacol. 2012;82(6):573–581.
• Halliwell B et al. FEBS Lett. 2018;592(20):3357–3366.

Synergy Overview

Mitochondrial Biogenesis & Cellular Energy: Alpha Lipoic Acid (ALA), PQQ, CoQ10, and MitoPrime form the core of the formula’s mitochondrial support system. ALA and CoQ10 work within the electron transport chain to enhance ATP output, while PQQ triggers mitochondrial biogenesis through PGC-1α activation. MitoPrime (ergothioneine) uniquely accumulates in mitochondria and long-lived cells, scavenging reactive oxygen species and preventing mitochondrial DNA damage. Together, this quartet sustains cellular energy and resilience under oxidative stress.

Liver Detoxification & Cytoprotection: N-Acetyl L-Cysteine (NAC), Milk Thistle (silymarin), Oleano 35 (oleanolic acid), and ALA synergize to protect hepatocytes and promote glutathione synthesis. NAC and Milk Thistle enhance intracellular antioxidant capacity, while Oleano 35 upregulates detoxification enzymes and reduces hepatic fat accumulation. Curcumin and Berberine add anti-inflammatory and lipid-modulating support, rounding out a robust hepatic defense network.

Cardiovascular Health & Endothelial Function: Citrus Bergamot, Arjuna, Grape Seed Extract, and CoQ10 work in harmony to support blood vessel tone, cholesterol balance, and nitric oxide signaling. Arjuna and Bergamot help modulate blood lipids and support left ventricular function, while grape seed polyphenols improve microvascular integrity. CoQ10 enhances endothelial energy supply and resilience. Combined, they offer comprehensive vascular protection and heart health optimization.

Metabolic Regulation & Glucose Control: Berberine, ALA, Citrus Bergamot, and Oleano 35 all converge on metabolic pathways to improve glucose handling and insulin sensitivity. Berberine activates AMPK and modulates gut microbiota, while ALA supports insulin signaling and glucose oxidation. Citrus Bergamot complements these effects with its impact on triglycerides and fatty acid metabolism. This metabolic synergy may help support healthy blood sugar levels and body composition.

Nutrient Absorption & Bioavailability Enhancement: AstraGin and BioPerine play complementary roles in enhancing nutrient uptake. AstraGin increases transporter expression in the gut, improving amino acid and polyphenol absorption, while BioPerine inhibits metabolizing enzymes and boosts bioavailability of curcumin, CoQ10, and Berberine. Their combined action ensures the full potency of the formula is realized at the cellular level.

Oxidative Stress Defense & Inflammatory Modulation: Curcumin, NAC, ALA, Grape Seed, and Milk Thistle form a high-impact antioxidant matrix targeting free radicals, lipid peroxidation, and inflammatory cytokines. PQQ and MitoPrime reinforce this network at the mitochondrial and genomic levels, providing protection where oxidative damage originates. These compounds also modulate Nrf2 and NF-κB signaling, contributing to whole-body anti-inflammatory effects.

FAQ

Q: What’s the main shift in this new formula?

A: The new version has evolved into a full-body health and resilience stack, supporting:

• Organ detox + function (liver, heart, kidneys)
• Blood sugar + lipid balance
• Mitochondrial and antioxidant defense
• Cardiovascular flow + endothelial health
• Cellular longevity + gene expression
• Biomarker optimization (AST, ALT, CRP, GGT, triglycerides, LDL, etc.)

This is no longer just organ support, it’s whole-body internal optimization.

Q: What were the biggest upgrades or additions?

New Key Additions:

• Alpha Lipoic Acid (600 mg) – systemic antioxidant, insulin sensitivity, liver enzyme regulation
• Berberine HCl (500 mg) – blood glucose, lipid profile, gut-liver axis
• Oleanolic Acid (250 mg) – hepatoprotective and anti-inflammatory
• PQQ (20 mg) – mitochondrial biogenesis and neurovascular health
• MitoPrime L-Ergothioneine (5 mg) – rare amino acid antioxidant for cellular repair
• Grape Seed Extract (95% OPC, now 200 mg) – vascular integrity + anti-inflammatory
• BioPerine reduced from 20 mg → 5 mg for better tolerance

Q: What ingredients stayed and still deliver clinical value?

Retained from Old Formula:

• NAC (600 mg) – glutathione precursor, liver detox
• Arjuna (500 mg) – cardiovascular and liver perfusion support
• Citrus Bergamot (500 mg) – cholesterol, inflammation, fatty liver support
• Turmeric (500 mg, 95%) – anti-inflammatory, liver enzyme and bile regulation
• Milk Thistle (250 mg, 80% silymarin) – liver repair and cell regeneration
• CoQ10 (50 mg) – mitochondrial + cardiovascular energy
• AstraGin (50 mg) – enhances uptake of amino acids and plant bioactives

Q: What ingredients were removed and why?

Removed or Reduced:

• CardioAid Plant Sterols (800 mg) – replaced by multi-system metabolic support; added to the new HEART + LIPIDS
• Red Yeast Rice (600 mg) – moved to the new HEART + LIPIDS
• High-dose BioPerine (20 mg) – reduced for improved GI tolerance as well as easier stacking with other products containing BioPerine

These changes reflect a move to multi-pathway organ and metabolic protection product.

Q: Is the new formula better for blood work?

A: Yes, the new formula can help support improvement in:

• Liver enzymes (ALT, AST, ALP, GGT) — NAC, ALA, milk thistle, turmeric
• Cholesterol + triglycerides — berberine, bergamot, grape seed
• Inflammation markers (e.g. CRP) — curcumin, ALA, PQQ, MitoPrime
• Fasting glucose + A1C — berberine, ALA, CoQ10
• Kidney markers + bile flow — oleanolic acid, arjuna, grape seed

Q: How do I take it?

A:

• Consume six (6) capsules daily, all together or spaced apart
• Best Timing: Spaced apart, with your largest meals (for absorption of fat-soluble actives)
• Hydration: Essential for detox and liver/kidney support
• Stacks With: MULTI, OMEGA, or HEALTH Series product
• Cycle: No cycling needed; designed for long-term, daily use

Q: Who should take this?

A:

• Anyone looking to optimize internal health, organs, and lab values
• Individuals under high physiological or toxic load
• Athletes using supplements, PEDs, or high-protein diets
• People focused on longevity, inflammation control, and aging biomarkers
• Anyone concerned with cholesterol, blood sugar, or liver function