Vitamin D3 (Cholecalciferol, vegan) – 20 mcg (800 IU)
A fat-soluble vitamin that regulates calcium metabolism, immune response, and endocrine function.
- Supports testosterone synthesis and luteinizing hormone signaling
- Improves bone density and reduces fracture risk
- Enhances immune surveillance and reduces chronic inflammation
- Contributes to neuromuscular performance and mood balance
Synergy: Works with magnesium, zinc, DIM, and saw palmetto to optimize androgen status and reduce estrogenic burden.
- Holick MF. N Engl J Med. 2007;357(3):266–281
- Pilz S et al. Clin Endocrinol (Oxf). 2011;75(5):658–665
- Lerchbaum E, Obermayer-Pietsch B. Eur J Endocrinol. 2012;166(5):765–778
- Wehr E et al. Clin Endocrinol (Oxf). 2010;73(2):243–248
Vitamin B6 (Pyridoxal-5’-Phosphate) – 1.7 mg
The active coenzyme form of vitamin B6, vital for neurotransmitter synthesis and homocysteine regulation.
- Promotes dopamine and serotonin production
- Assists in estradiol clearance
- Enhances cognitive clarity and energy
- Supports cardiovascular and immune health
Synergy: Works with B12, folate, and magnesium to support methylation and mood regulation.
- Dakshinamurti K et al. Brain Res Brain Res Rev. 1993;18(1):57–69
- Ubbink JB et al. Clin Chem Lab Med. 1996;34(8):747–751
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- Richards SD et al. Biochem J. 1985;229(3):705–709
Folate (as 5-MTHF) – 400 mcg DFE
Bioactive methylated folate used directly in methylation and nucleotide synthesis.
- Supports DNA synthesis and red blood cell formation
- Regulates homocysteine and cardiovascular risk
- Aids neurotransmitter balance and hormone detox
- Enhances fertility and reproductive health
Synergy: Complements B6 and B12 for methylation and hormone detoxification.
- Bailey SW, Ayling JE. Clin Chem. 2009;55(11):1911–1923
- Selhub J. J Nutr. 1999;129(9):1731–1736
- Reynolds EH. Lancet. 1985;1(8431):862–864
- Tamura T et al. Nutrients. 2012;4(11):999–1014
Vitamin B12 (Methylcobalamin) – 2.4 mcg
Coenzyme form of B12 essential for red blood cell production, nerve health, and methylation.
- Supports myelin and neurological function
- Helps regulate homocysteine
- Boosts mitochondrial energy metabolism
- Plays a role in testosterone and neurotransmitter synthesis
Synergy: Works with B6, folate, and zinc for methylation and hormone signaling.
- Stabler SP. Blood. 2013;121(18):3471–3480
- O’Leary F, Samman S. Int J Food Sci Nutr. 2010;61(6):588–599
- Reynolds EH. Ann Clin Biochem. 2006;43(Pt 5):344–356
- Scalabrino G. J Neurol Sci. 2009;285(1–2):9–13
Zinc (Albion Bisglycinate Chelate) – 11 mg
A trace mineral required for testosterone production, sperm health, and immune function.
- Promotes testicular function and testosterone synthesis
- Supports sperm count and motility
- Regulates 5α-reductase activity and DHT balance
- Enhances skin, immune, and wound healing functions
Synergy: Complements vitamin D, selenium, and DIM for androgen balance and prostate health.
- Prasad AS. Am J Clin Nutr. 1996;64(2):433S–438S
- Hunt CD et al. J Nutr. 1992;122(4):924–932
- Netter A et al. Trace Elem Electrolytes. 1981;2:103–109
- Fallah A et al. Biol Trace Elem Res. 2018;183(1):22–28
Selenium (Albion Glycinate) – 55 mcg
A trace element that supports thyroid function, sperm quality, and antioxidant defenses.
- Reduces oxidative stress in testes and prostate
- Protects DNA and mitochondrial membranes
- Regulates thyroid hormone activity
- May improve sperm motility and quality
Synergy: Partners with zinc and vitamin E to defend testicular function.
- Hawkes WC, Turek PJ. Biol Reprod. 2001;65(3):871–875
- Behne D et al. Biol Trace Elem Res. 1996;54(2):147–161
- Rayman MP. Lancet. 2012;379(9822):1256–1268
- Scott R et al. Br J Urol. 1998;81(5):730–734
Copper (Albion Bisglycinate) – 0.9 mg
An essential mineral for iron metabolism, connective tissue integrity, and redox balance.
- Prevents copper-deficiency anemia
- Supports enzyme systems for inflammation control
- Required for collagen, elastin, and vascular health
Synergy: Maintains zinc:copper ratio to prevent imbalance and neurological symptoms.
- Turnlund JR et al. Am J Clin Nutr. 2004;79(6):1037–1044
- Collins JF et al. Nutr Rev. 2010;68(10):521–538
- Medeiros DM. Adv Exp Med Biol. 1999;472:77–85
Myo-Inositol – 1,000 mg
A vitamin-like compound involved in hormone signal transduction and insulin metabolism.
- Improves insulin sensitivity and hormone feedback loops
- Modulates LH and FSH signaling
- Reduces stress-induced anxiety
- Supports sperm morphology and quality
Synergy: Works with zinc, selenium, and folate to support metabolic-hormonal axis.
- Nestler JE et al. N Engl J Med. 1999;340(17):1314–1320
- Genazzani AD et al. Gynecol Endocrinol. 2008;24(3):139–144
- Dinicola S et al. Eur Rev Med Pharmacol Sci. 2014;18(13):1896–1903
Go-Less Men (Pumpkin Seed Extract) – 500 mg
A lipid-free extract supporting urinary comfort and prostate health.
- Reduces urinary urgency and frequency
- Protects bladder detrusor muscle tone
- Supports prostate size reduction
Synergy: Enhances saw palmetto, pygeum, and nettle for full-spectrum urinary health.
- Vahlensieck W et al. Urologe A. 2015;54(11):1561–1568
- Carbin BE et al. Clin Ther. 1990;12(6):574–579
- Gossell-Williams M et al. Phytother Res. 2006;20(1):82–85
Maca Root Extract (4:1) – 500 mg
A traditional adaptogen from Peru supporting libido, mood, and energy.
- Enhances libido and sexual performance
- Improves mood and stress resilience
- Supports male fertility
Synergy: Works with zinc and pregnenolone for vitality and reproductive support.
- Gonzales GF et al. J Ethnopharmacol. 2001;75(2–3):225–229
- Brooks NA et al. Menopause. 2008;15(6):1157–1162
- Stone M et al. CNS Neurosci Ther. 2009;15(2):152–157
Tomato Extract (5% Lycopene) – 400 mg
A potent antioxidant carotenoid extracted from tomato, concentrated for prostate health.
- Protects against prostate oxidative damage
- Inhibits IGF-1 and androgen-induced prostate growth
- Supports cardiovascular and skin health
Synergy: Acts with saw palmetto and pygeum for prostate defense.
- Giovannucci E. J Natl Cancer Inst. 1995;87(23):1767–1776
- Rao AV et al. Nutr Cancer. 1999;31(3):199–203
- Gann PH et al. Cancer Res. 1999;59(1):1225–1230
Saw Palmetto Extract – 400 mg
A lipophilic extract from the berries of Serenoa repens, rich in fatty acids and sterols.
- Inhibits 5α-reductase and DHT activity
- Relieves urinary symptoms of BPH
- May enhance free testosterone by reducing DHT
Synergy: Works with nettle, pygeum, DIM, and lycopene for prostate and hormonal support.
- Marks LS et al. J Urol. 2000;163(5):1451–1456
- Bent S et al. JAMA. 2006;295(17):2057–2065
- Vela-Navarrete R et al. J Urol. 2002;168(4 Pt 1):1444–1450
Stinging Nettle Root Extract – 360 mg
A root extract that binds SHBG and modulates inflammatory signals in the prostate.
- Inhibits binding of testosterone to SHBG
- Reduces BPH-related inflammation and edema
- Supports androgen availability and urinary flow
Synergy: Enhances saw palmetto, zinc, and DIM effects on hormone balance and prostate size.
- Chrubasik JE et al. Phytomedicine. 2007;14(7–8):568–575
- Lichius JJ, Muth C. Planta Med. 1997;63(6):500–503
- Hryb DJ et al. J Steroid Biochem Mol Biol. 1995;54(3–4):273–279
Pygeum africanum Extract – 250 mg
A bark extract traditionally used to treat urinary and prostate disorders.
- Reduces prostate inflammation and nocturia (night time urination)
- Improves urinary flow rate and bladder emptying
- May reduce 5α-reductase activity and prostate volume
Synergy: Works with saw palmetto, pumpkin seed, and lycopene to support urinary tract and prostate size.
- Breza J et al. Eur Urol. 1998;33(3):159–163
- Paubert-Braquet M et al. Prostaglandins Leukot Essent Fatty Acids. 1996;54(3):189–197
- Boyle P et al. Br J Urol. 2004;93(6):751–758
DIM (Diindolylmethane) – 100 mg
A bioactive compound from cruciferous vegetables that modulates estrogen metabolism.
- Promotes 2-hydroxyestrone (good estrogen) over 16α-hydroxyestrone (bad estrogen)
- Reduces aromatase activity and estrogen dominance in men
- May support prostate health and testosterone:estrogen ratio
Synergy: Works with zinc, B6, and saw palmetto to optimize androgen-to-estrogen balance.
- Zeligs MA. Integr Cancer Ther. 2004;3(1):56–62
- Chen DZ et al. Cancer Res. 1998;58(21):4837–4843
- Dalessandri KM et al. Nutr Cancer. 2004;50(2):161–167
AdoniXYN (Prunus africana extract) – 50 mg
A branded, next-gen plum tree bark extract standardized for beta-sitosterol and polyphenols.
- Supports urinary health and prostate size regulation
- Provides anti-inflammatory sterols and antioxidants
- Modulates androgen signaling at the prostate receptor level
Synergy: Enhances the effects of pygeum, saw palmetto, and HMRlignan on lower urinary tract health.
- Andriole GL et al. Curr Urol Rep. 2001;2(6):496–502
- Buck AC. Br J Urol. 1996;78(3):325–336
- Schulze-Tanzil G et al. J Ethnopharmacol. 2002;81(1):73–79
HMRlignan (Norwegian Spruce Extract) – 30 mg
A lignan complex from spruce standardized for secoisolariciresinol diglucoside (SDG), supporting hormone and prostate health.
- Promotes hormonal balance via phytoestrogen receptor modulation
- Provides potent antioxidant and anti-inflammatory activity
- May help reduce PSA levels and protect prostate DNA
Synergy: Complements DIM and lycopene for synergistic endocrine and cellular protection.
- Landete JM. Crit Rev Food Sci Nutr. 2012;52(4):243–268
- Saarinen NM et al. Mol Cell Endocrinol. 2007;278(1–2):13–25
- Mousavi Y, Adlercreutz H. J Steroid Biochem Mol Biol. 1992;41(3–8):615–619
Pregnenolone – 10 mg
A neurosteroid precursor to DHEA, testosterone, progesterone, and cortisol.
- Supports hormone cascade balance upstream of androgens
- Enhances memory, alertness, and mood via neurosteroid effects
- May reduce fatigue and support mitochondrial function
Synergy: Amplifies the endocrine effects of maca, zinc, DIM, and vitamin D3.
- Genazzani AR et al. Gynecol Endocrinol. 2010;26(9):673–678
- Mellon SH. Front Neuroendocrinol. 2007;28(1):1–14
- Vallee M et al. Pharmacol Ther. 2001;92(1):1–31
Synergy Overview
Hormonal Balance: Zinc, vitamin D3, DIM, and pregnenolone regulate testosterone synthesis, support favorable estrogen metabolism, and reduce conversion to DHT, contributing to optimal androgen signaling without overstimulation.
Prostate Health & Urinary Flow: Saw palmetto, stinging nettle, pygeum, lycopene, Go-Less pumpkin seed extract, and AdoniXYN work together to reduce inflammation, inhibit 5α-reductase, relax smooth muscle tone, and shrink prostate volume—alleviating common BPH-related symptoms.
Reproductive & Sexual Vitality: Maca, zinc, selenium, myo-inositol, and vitamin B12 enhance sperm quality, libido, erectile response, and testicular function, while supporting broader fertility and androgenic tone.
Estrogen Detoxification: DIM, B6, folate, and B12 aid in phase I and phase II estrogen metabolism and methylation, helping shift estrogen pathways toward anti-proliferative metabolites and reducing xenoestrogen burden.
Mood & Cognitive Support: Myo-inositol, pregnenolone, vitamin B6, and B12 contribute to stress modulation, neurotransmitter balance, and cognitive clarity, supporting the neuroendocrine axis as part of holistic male wellness.