Selective Androgen Receptor Modulators (SARMs) are a controversial topic in the pharmaceutical and supplement industries. They offer great promise; but due to the fact that they're investigational prescription drugs owned by big pharma (at worst), or unlicensed "research chemicals" with little-to-no published research (at best), they're a far way off from being commercially approved.
Hi-Tech Pharmaceuticals is about to put the industry on notice though, with its latest groundbreaking formula which they believe has the ability to selectively target androgen receptors in muscle tissue, while not binding to the androgen receptors in other tissues and organs -- exactly what SARMs do!
Osta-Plex from Hi Tech is the first legal SARM . It is the most powerful selective androgen receptor modulator ever developed to help you truly recomp your physique.
We've got TONS more info to come, but first, take a moment to check the best deal and sign up for alerts from PricePlow on this page!
In addition to the issues in the first paragraph, the SARM ingredients sold in past years are not found in nature, so they're not DSHEA compliant and are definitely not "supplements". But Hi-Tech Pharma claims to have found these mechanisms in nature:
Osta-Plex is a powerful combination of both steroidal and nonsteroidal natural SARMs that produce amazing muscle and strength gains like you've never seen from any OTC supplement before.
19-nor-androst-4-ene-17-one Enanthate (50mg)19nor-DHEA is an extremely powerful, and legal, prohormone that converts to one of three different hormones:19-norAndrostenedione, 19-norAndrostenediol, and & 19-NorTestosterone, a.k.a. nandrolone. Note that 19nor-DHEA is a one-step prohormone to 19-norAndrostenedione and 19-norAndrostenediol, and a two-step prohormone to nandrolone.
The upside to 19nor-DHEA over other prohormones, such as 4-andro, is that it is already 5-alpha-reduced, meaning it won't convert to dihydrotestosterone (DHT) or estrogen. Plus, 19nor-DHEA also binds to androgen receptors better than even testosterone!
A recent study on showed that consuming 25mg 19-norAndrostenediol via sublingual tablet resulted in blood levels of nandrolone equivalent or greater than 100mg's of straight nandrolone injections. Additionally, other research notes that 19-norAndrostenedione stimulates skeletal muscle growth in a highly selective manner but hardly exerts any androgenic activity.The takeaway is that 19-norAndrostenedione will benefit muscle mass and strength gains, but not significantly affect prostate growth (mimicking the actions of a SARM). Hi-Tech's using an ethanated version of 19-norDHEA which is a long-acting form of the popular prohormone, and is a SARM-like compound, based on the it exhibiting similar properties to that of a steroidal SARM (i.e. increase muscle mass without excessive prostate growth).
Ultimately, this is undoubtedly a bulker's ingredient, since it may help you retain water, and will give you that "swole" effect. So we have to call Osta-Plex a bulking supplement as well.
Get blood work!
As with all prohormones, we highly recommend blood tests before, during and after (for estrogen at the bare minimum, but also testosterone, liver enzymes, and lipids if you can afford it), and a proper round of post cycle therapy after your cycle.
As discussed in our main 19-nor-DHEA writeup, this is quite an interesting ingredient, but we never really thought it was going to be the end-all-be-all on its own, except for a few key demographics (such as those who miss deca and want some joint lubrication). That's where the natural phyto-SARM ingredients come in to bring additional effects!
Eucommia Ulmoides 100:1 Extract (bark) (250mg)
Up next is the first of two phyto-SARMS in Osta-Plex, an Ethanolic 80:1 extract of Eucommia ulmoides -- a traditional Chinese medicine whose bark was routinely used for its medicinal and anti-inflammatory properties. Eucommia ulmoides contains over 100 compounds including lignans, fatty acids, iridoids, triterpenoids, and many other active compounds.
As it turns out, Eucommia ulmoides possesses some fairly strong androgenic activity for a plant. To confirm this researchers set out to investigate what effect, if any, Eucommia ulmoides extract had on sex steroid receptors, sex hormones, and lipids derived from plants. As it turns out, Eucommia ulmoides did exert androgenic activities by weakly activating androgen receptors in a dose-dependent manner.
What was especially interesting, was that the e. Ulmoides extract only mildly activated the androgen receptor by 6%. But when the extract was used with testosterone, the combo activated the androgen receptor and spurred it to transcribe over twice its normal capacity! In this particular study, that meant activity was increased to 240%!
Who knew plants could be so useful for muscle-building?!
Hi-Tech was the first company to really bring Phytochemical SARMs, or P-SARMS, to market way back in 2008. The compound was 7-methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one (a.k.a. Osthole or osthol!) and was introduced by one of Hi-Tech's subsidiary companies, LG Sciences.
P-SARMS are plant-derived (phyto) (plant-derived) compounds that mimic the actions and effects of androgens on lean muscle mass, strength, bone growth, and sexual function, all without negatively affecting blood lipids or blood pressure. The real key to the pSARM is its molecular shape, which is incredibly similar to testosterone, enabling it to function very similarly to testosterone in muscle tissue.
Check out the picture to the right and note the molecular position of 7-methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one. You'll quickly see how it's remarkably similar to testosterone, and because of this, it will have behave similar to testosterone without adversely impacting the prostate or liver. In fact, recent research on the compound yielded the following:
"RESULTS: Testosterone, LH and FSH were significantly increased at the high dose of osthol treatment. The high and low dose of osthol treatment significantly enhanced the activity of NOS (P < 0.01). CONCLUSION: osthol could increase androgen, gonadotropin and nitric oxide synthase (NOS) activity. It suggested that osthol had androgen-like effect and gonadotropin-like effect."
The combination of all these ingredients is how Osta-Plex can deliver SARM-like results without venturing into the dangerous, and uncharted, territory of true SARMs.
Cyclosome Encapsulation for better absorption
To really amp up the effectiveness of Osta-Plex, Hi-Tech has included their patented Cyclosome delivery system. Here, the active ingredients are suspended in a lipid and then placed in a cyclodextrin. Think of Cyclosome as a "best of both worlds" approach to encapsulation where you encapsulate the hormone in a sugar molecule and place lipid-based delivery system around it.
We've got a full blown mega post on Cyclosome here, but the jist of it is that lipid encapsulations makes the compounds in Osta-Plex more bioavailable orally. It's frequently been used with the likes of curcumin (where "Phytosome" is often used) and prescription drugs, but more recently, Hi-Tech Pharma has been using it with all of their new prohormones.
For all the info on Cyclosome, see our in-depth article titled: Cyclosome: New Age Liposome + Cyclodextrin Delivery System.
Hi-Tech suggests taking 1 tablet in the morning, and another tablet in the evening, for a grand total of two (2) per day. Although, they do have another statement following this that says "Do not exceed 4 per day."....which seems a bit confusing.
Post cycle therapy?
Due to the fact that this contains a prohormone, we do urge following a PCT and blood testing protocol. You can read about this on our post cycle therapy page and we discuss it more on our 19-nor-DHEA page.
As discussed in our main SARMs write-up from 2015, true pharmaceutical SARMs most definitely not supplements, and are a long, long way from becoming commercially available in the prescription drug world. So until that time comes, you're going to have to use the next best thing... Osta-Plex.
Hi-Tech is very confident that they've turned that [illegal] SARM market on its head with this one - and legally while they're at it. The unique combination of ingredients delivers all of the benefits you'd want (muscle-building, libido, endurance) without as many unknown side effects.
- Tiwari, Gaurav, Ruchi Tiwari, and Awani K. Rai; "Cyclodextrins in Delivery Systems: Applications"; Journal of Pharmacy and Bioallied Sciences 2.2 (2010): 72–79; Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147107/
- Indena; Phytosome; Retrieved from http://www.indena.com/pdf/phytosome_int.pdf