EvoMuse Atomic Meltdown

Evolutionary Muse
Atomic Meltdown

Ingredients

Yohimbine

Since we already covered the adrenaline receptors a bit we can start there. In the Yohimbe tree there is a specialized compoound called Yohimbine. Yohimbine is entirely unique in this world, as it has the ability to block those pesky A2 receptors (the ones that turn off fat burning and are responsible for those ugly fat deposits). When you block the A2 receptors, you allow adrenaline/nor-adrenaline (and a few other lipolytic compounds) to trigger rapid lipolysis. Yohimbine (much like the other compounds in the formula) are small enough to penetrate through the skin and into the fat deposits below. Sounds incredible, but think of the nicotine patch. You stick it to your skin and the nicotine is small enough to pass right through the skin.

Forskolin

Forskolin comes from the Coleus Forskohlii plant. A very interesting compound, especially for fat loss. Forskolin helps to increase a chemical called cAMP (cyclic Adenosine Monophosphate), which is a compound in your body that increases when fuel is low. An increase in cAMP signals to your fat cells that they need to release some of that fat to be used for fuel. There will be several overlaps here in this product, so we will start here. It turns out that elevating cAMP levels not only activates lipolysis, but by adjusting melanocyte pH, it increases melanin production. The bad news is that elevating cAMP results in an increase in an enzyme called GSK3b, which decreases melanogenesis...but have no fear, we have that covered.

https://www.science.org/doi/10.1126/stke.2002.150.tw339/

Myricetin

Myricetin is a complicated molecule. For starters, it potently inhibits an enzyme called Glycogen Synthase Kinase 3b (which increases melanogenesis) and prevents lipolysis. By inhibiting GSK3b we not only increase lipolysis, but melanogenesis as well.

pubmed.ncbi.nlm.nih.gov

GSK3beta inhibition promotes melanogenesis in mouse B16 melanoma cells and normal human melanocytes - PubMed
Glycogen synthase kinase 3beta (GSK3beta) is implicated in many biological events, including embryonic development, cell differentiation, apoptosis, and the insulin response. GSK3beta also plays a key role in the Wnt/beta-catenin pathway. The master regulator of the pigmentation...

pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

It is also a GLP-1 receptor agonist (which means it activates the receptor similarly to GLP-1). With GLP-1 everywhere in the news, hopefully you are familiar with its effects on fat loss and appetite. And it turns out that activating the GLP-1 receptor increases melanogenesis as well.

https://www.mdpi.com/2079-9721/13/5/127/

As well, Myricetin activates and stabilizes a system called WNT/b-catenin, which controls a whole lot of related processes. It stimulates the production of Tyrosinase and increases proliferation of melanocytes.

https://pubmed.ncbi.nlm.nih.gov/27138625/

pubmed.ncbi.nlm.nih.gov

Wnt/β-catenin signaling is stimulated by α-melanocyte-stimulating hormone in melanoma and melanocyte cells: implication in cell differentiation - PubMed

Wnt/β-catenin signaling plays important roles in many developmental processes including neural crest-derived melanocyte development and migration. However, the effective contribution of Wnt/β-catenin pathway in melanogenesis in adult human melanocytes has not been fully elucidated. Here, we...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Myricetin also shows great promise as an anti-cancer agent.

https://www.sciencedirect.com/science/article/pii/S0753332219337771/

Theophylline

Theophylline is found in cocoa and coffee. It has actions on the body similar to adrenaline (see those B2 receptors), causing lipolysis. It also works on the cAMP molecule and increases something called Hormone Sensitive Lipase – all necessary for lipolysis. Theophylline dramatically increases the activity of an enzyme called tyrosinase. Tyrosinase reacts with the amino acid Tyrosine to increase L-Dopa (see below). This then gives us the metabolite L-Dopaquinone, the main compound responsible for melanogenesis. Theophylline is an extremely potent addition to the formula.

https://pubmed.ncbi.nlm.nih.gov/7243846/

https://pubmed.ncbi.nlm.nih.gov/8496620/

Stearoyl Vanillylamide

SV as we will call it is an activator of the TRPV1 receptor that we covered above. As you recall, the TRPV1 receptor reacts to heat – such as would be generated when exposed to sunlight. TRPV1 activation is a tricky thing. Too strong, and we get the opposite effect (inhibition of melanogenesis). It turns out that SV, which is much weaker than Capsaicin, offers just the right amount of activation to increase melanin production. Too strong a TRPV1 activation also leads to photoaging of the skin, which we want to avoid.

https://pubmed.ncbi.nlm.nih.gov/34363226/

TRPV1 activation also increases lipolysis by assisting the breakdown of fat stored in fat cells into the form released into the bloodstream to be burned.

https://pubmed.ncbi.nlm.nih.gov/25849380/

Vanilloid receptors – Do they have a role in whole body metabolism? Evidence from TRPV1 - PMC
With increasing lifespan, therapeutic interventions for the treatment of disorders such as type 2 diabetes mellitus are in great demand. Despite billions of dollars invested to reduce the symptoms and complications due to diabetes mellitus, current ...

pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

11b-Glycyrrhetinic Acid

11b-GA is a component of licorice. It is well known to potently decrease expression of an enzyme called 11b-HSD. 11b-HSD converts inactive cortisone into a potent stress hormone called Cortisol, which is highly active in the skin and subcutaneous fat. Elevated cortisol not only increases inflammation, but also causes the body to store fat around the organs, called Visceral Fat, and increases waist size and abdominal fat. Elevated cortisol also dramatically decreases melanocyte activity, which inhibits melanin production.

https://pmc.ncbi.nlm.nih.gov/articles/PMC4031121/
https://pubmed.ncbi.nlm.nih.gov/16353426/

Arachidonic Acid/Beta-Aescin

The subject of prostaglandins in the body is complex. One of the most primitive “systems”, the 2-series prostaglandins (our interest is PGF2a) are direct responses to cellular injury. Within the cell membrane is a fatty acid called Arachidonic Acid. When the cell is perturbed or otherwise damaged, the Arachidonic Acid is released, reacts with enzymes, and produces PGF2a (among many other products). This prostaglandin starts a cascade of signals that generally start rapid healing, including raiding local fat cells for their contents. The end result is a pretty decent lipolytic effect in the area. In the case of UV exposure beyond a certain amount, the body certainly considers this as an “injury” (those that have felt sunburn will understand). In reponse, PGF2a rapidly and potently works with melanocytes to increase tyrosinase, and finally melanin.

Beta-Aescin is a compound extracted from Horse Chestnuts. Application to the cells in the body shows a potent induction of PGF2a production. By combining Arachidonic Acid and Beta-Aescin, the response is rapid and dramatic.

pubmed.ncbi.nlm.nih.gov

The mode of action of aescin and the release of prostaglandins - PubMed
The horse-chestnut saponin Aescin, an anti-exudative compound, induces contraction of isolated portal vein of rat and rabbit. This effect appears to be mediated by Prostaglandins of Falpha type. The ability of Aescin to stimulate generation and release of Prostaglandins has been demonstrated in...

pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

https://pubmed.ncbi.nlm.nih.gov/37108173/

pubmed.ncbi.nlm.nih.gov
Effects of PGF2alpha on human melanocytes and regulation of the FP receptor by ultraviolet radiation - PubMed
Prostaglandins are potent lipid hormones that activate multiple signaling pathways resulting in regulation of cellular growth, differentiation, and apoptosis. In the skin, prostaglandins are rapidly released by keratinocytes following ultraviolet radiation and are chronically present in...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

L-Dopa/Dopaquinone/Cyclodextrins

L-Dopa and Dopaquinone are a product of tyrosine reacted with the tyrosinase enzyme. They are intermediates in the formation of dopamine, a potent neurotransmitter.

https://pubmed.ncbi.nlm.nih.gov/33339254/

https://pubmed.ncbi.nlm.nih.gov/3143738/

The only problem with L-Dopa is that it is virtually insoluble in most solvents. If it doesn’t dissolve, then it certainly isn’t going to do anything when applied topically to the skin. However, it turns out that we can use nifty little donut-shaped molecules called Cyclodextrins to “hide” the L-Dopa in solvents like water. This allows us to apply it to the skin, and still be able to increase melanogenesis.

Theobromine

Closely related to Theophylline in both source and function, Theobromine comes from coffee, tea, chocolate, etc. Theobromine has a very intense stimulating effect on melanocytes, mostly in increasing cAMP. These same pathways not only induce melanogenesis, but increase lipolysis as well.

https://pmc.ncbi.nlm.nih.gov/articles/PMC9702281/

L-Carnitine

L-Carnitine is an amino acid that is essential to the proper functioning of the body. It is used to shuttle fatty acids in the bloodstream into the mitochondria where they can be burned. L-Carnitine also has a potent anti-aging effect on the skin, and has evidence showing it to effect against acne. Carnitine also shows potent effects against ultraviolet damage to skin.

https://pubmed.ncbi.nlm.nih.gov/22360332/

L-carnitine mitigates UVA-induced skin tissue injury in rats through downregulation of oxidative stress, p38/c-Fos signaling, and the proinflammatory cytokines - PubMed
UVA comprises more than 90% of the solar UV radiation reaching the Earth. Artificial lightening lamps have also been reported to emit significant amounts of UVA. Exposure to UVA has been associated with dermatological disorders including skin cancer. At the molecular level, UVA damages different...

pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Methylpalmitate

When researching botanicals for effects on melanin production, an herb called Lotus Flower stood out. The essential oil induced an extremely potent increase in melanin production. A thorough analysis of the oil, and subsequent testing showed that the Methylpalmitate in the oil was the one responsible. Methylpalmitate induced a dramatic increase in tyrosinase activity. As well, being a fatty acid, the Methylpalmitate will not penetrate past the skin, but instead impart a potent anti-wrinkle and anti-aging effect.

https://pubmed.ncbi.nlm.nih.gov/19322028/

Black Cumin Seed Oil

Black Cumin Seed Oil (or just Black Seed Oil) has been prized for centuries for its miraculous properties, such as for pain relief. BSO contains many compounds of interest, such as Thymoquinone, which not only dramatically increases melanin production, but acts as a potent antioxidant and antiinflammatory. Recent research has also shown that BSO contains compounds that preserve collagen and elastin in the skin, keeping the skin pliable and reducing the appearance of photoaging and sagging.

https://pubmed.ncbi.nlm.nih.gov/31057097/

Tyrosine

Extremely straightforward, Tyrosine is the amino acid that eventually, when acted upon by Tyrosinase, becomes Melanin and dopamine. Ensuring that the skin has enough Tyrosine readily available guarantees maximum color.

In our minds we have the perfect picture of what we want to look like. For health, for confidence, to be attractive – we can see exactly what we want. Sometimes, though, turning that vision into reality is complicated. Atomic Meltdown is the result of hundreds of hours of research, both on lipolysis and melanin production (tanning). The functional crossover of multiple ingredients makes it possible in our proprietary formula to target specific areas of the body to reduce fat as well as induce tanning, bringing you that much closer to the YOU you want to be.

DIRECTIONS: Apply a small amount on a test area prior to full body usage. Apply a thin layer over body before UV exposure. Be careful around the eyes and genital area. For external use only. Tanning bed safe.