Core Nutritionals FURY Black

L-Citrulline

Citrulline is a non-essential, non-protein amino acid that forms during the urea cycle and forms ornithine when combined with carbon dioxide. Citrulline is also a critical source of endogenous (natural) arginine, as it is rapidly and efficiently converted to arginine in the vascular endothelium and other tissues.

Citrulline’s benefits have been shown to be greater than its parent compound. While arginine undergoes direct hepatic (liver) metabolism through the enzyme arginase, citrulline bypasses hepatic metabolism entirely and it is delivered straight to the bloodstream. The result is that gut absorption and plasma (blood) bioavailability studies comparing citrulline and arginine have shown two things. First, citrulline is less readily destroyed and has greater absorption than arginine. Second, citrulline supplementation increases arginine levels more effectively than arginine supplementation itself.

This translates to promising results. For example, animal studies show a significant increase in anaerobic performance at a 250mg/kg/day serving of citrulline, while studies in humans implicate citrulline in both aerobic and anaerobic performance increases. As a critical part of the urea cycle, citrulline’s performance benefits are thought to be a result of its role in ammonia clearance. Citrulline is implicated in reducing the oxygen cost of muscle processes, along with increasing the rate of post-exercise ATP and phosphocreatine replenishment. As ATP and phosphocreatine are the body’s ‘exercise fuel,’ this may result in citrulline delaying time to exhaustion in aerobic and anaerobic exercise.

Betaine Anhydrous

Betaine, also known as trimethyl glycine, is a naturally occurring compound found in various living organisms. It serves as a protective agent in non-mammalian animals during osmotic stress and functions as an osmolyte in mammalian tissues, including those of humans. In mammalian cells, betaine is produced through the oxidation of choline and can be acquired from dietary sources such as spinach and beets. Although research on betaine is relatively limited and recent, available literature suggests its potential effects in several areas. Studies investigating betaine supplementation at doses ranging from 1.25g/day to 5g/day for up to 14 days have demonstrated promising results. For instance, one study found that a daily serving of 2.5g enhanced endurance and total repetition volume during exercises like the squat, bench press, and jump squat in healthy, exercise-trained adults. Another study reported increased peak power, maximum peak power, force, and the maintenance of force and power in similar subjects with the same dosage of betaine. Moreover, research exploring betaine's impact on the endocrine system has shown potential effects on various endocrine processes. These findings have led researchers to hypothesize that longer-term betaine supplementation may enhance the hypertrophic response to resistance training, indicating its potential as a performance-enhancing supplement in the realm of exercise physiology.

Beta Alanine

Carnosine is a bit of an odd duck: we know that it is crucial for muscle function, and that dietary sources of carnosine are essential, but we don’t know precisely how it’s working. Moreover, for decades, we had no idea how to increase intramuscular concentrations, as exogenous carnosine sources degraded in the body so fast as to be effectively useless.

Enter beta-alanine. Simply a different iteration of one of the amino acids that comprises carnosine itself (alanine), beta-alanine has proven to be the most effective means of significantly increasing intramuscular concentrations of carnosine – and therefore of promoting all of carnosine’s various beneficial effects on muscle performance. If that weren’t enough, beta-alanine has also demonstrated beneficial physiological effects independent of its parent compound. To understand why, though, we need to first understand some of the basics behind carnosine itself.

Carnosine, a cytoplasmic dipeptide synthesized from the precursors L-histidine and l-alanine, is present in high concentrations in skeletal muscle and plays a pivotal role as a, “chemical buffer” in myocytes (muscle cells). It has long been known that carnosine concentrations are highest in glycolytic, rather than oxidative muscle fibers (roughly speaking, explosive vs., endurance muscle fibers, respectively), and thus long hypothesized that this amino acid is required for sustained performance during supramaximal exercise. Recent research demonstrates that carnosine exerts its physiological effects in long hypoxic (low oxygen) drives by functioning as a high-capacity pH buffer in skeletal muscle, preventing the pH ratio of plasma from dropping too low – and therefore preventing crucial pH-dependent processes such as protein synthesis from being inhibited by acidosis.

Despite its critical role in skeletal muscle anaerobic performance, intramyocellular synthesis of carnosine is rate-limited by the availability of l-alanine. Unfortunately, the majority of literature demonstrates that attempting to increase intramuscular levels of carnosine via either direct carnosine or alanine supplementation is largely ineffective due to carnosine/alanine pharmacokinetics. Enter beta-alanine. Research with beta-alanine demonstrates consistent and dose-dependent increases to intramuscular carnosine concentrations with beta-alanine supplementation, with certain studies showing an increase of 40-60% with chronic administration. These same literatures reveal a synergistic effect of exercise on beta-alanine supplementation, whereby the muscle adaptive changes associated with resistance training promote further intramuscular carnosine production in response to beta-alanine supplementation.

In simpler language, this essentially means that beta-alanine is a dietary supplement that promotes its own effects in combination with exercise. As you exercise, you simultaneously intensify beta-alanine’s physiological actions – both directly, as well as in the production of intramuscular carnosine. Once ingested, beta-alanine’s exercise-specific beneficial activity is well-established. Elevation of intramuscular carnosine content via beta-alanine supplementation has been shown to improve performance in the following ways.

• Both acute and chronic increases in total work capacity, measured by total volume during exercise sessions.
• Highly significant increases to TTE (total time to exhaustion), one of the most accurate and comprehensive measures of endurance. In various trials, beta-alanine supplementation has been shown to increase TTE by upwards of 20%.
• Increases to total muscle power output in both acute and chronic trials, suggesting that beta-alanine’s most significant benefit is to those engaging in power-dependent resistance training.

In total, a significant body of research exists to suggest that beta-alanine may significantly increase muscle power output, strength, training volume and output, overall performance in hypoxic (oxygen-deprived) conditions and peak VO2 max (oxygen holding capacity).

These myriad benefits make beta-alanine both one of the most-studied, and most well-rounded dietary supplements. Beta-alanine not only has direct, actionable physiological effects, but also promotes critical muscle physiologic adaptations that promote its own effects.

L-Tyrosine

Tyrosine is amongst a class of amino acids known as ‘non-essential’ amino acids, so called because the body can produce them endogenously, and it is therefore not essential to consume dietary tyrosine. That said, tyrosine is also what is known as a conditionally-essential amino acid; conditionally-essential because, along with glucose and ammonia, the synthesis of tyrosine additionally requires adequate levels of phenylalanine. Once synthesized, tyrosine is one of the most critical amino acids, given its prominent role as a substrate in the synthesis of the catecholamines dopamine, norepinephrine, and epinephrine, in addition to both T3 (triiodothyronine) and T4 (thyroxine) thyroid hormones.

In studies on stress modulation, tyrosine has been demonstrated to reverse stress-induced norepinephrine depletion and the depressant-behavioral effects normally associated with it. In simpler terms, tyrosine may, in certain conditions, dampen the extent to which norepinephrine is removed from the bloodstream during a stress event. In simpler terms still, tyrosine may help to mitigate the sense of depletion and fatigue felt at the end of a workout.

Tyrosine may also play important metabolic functions, mostly related to its role in synthesizing compounds which stimulate the nervous system. While not traditionally considered a sympathomimetic amine, studies which have coadministered tyrosine and stimulants demonstrate a synergistic effect. These studies suggest that tyrosine may potentiate the effects of both endogenous and supplemental norepinephrine and its mimetics (in the case of exogenous use) with respect to lipolysis, thermogenesis, and energy expenditure. This means that tyrosine may play a role in assisting norepinephrine to break up triglycerides and increase body heat transiently.

Taurine

Though traditionally referred to as an amino acid due to its chemical structure, taurine is not an amino acid in the sense that leucine, alanine, or glutamine are. Its chemical status aside, taurine is considered one of the body’s most essential chemical compounds, as cardiovascular function, muscle development and function, along with optical and nervous systems in the body depend on its abundance. While data on taurine typically occurs with taurine in supplement combinations (with caffeine and other amino acids), these data nevertheless suggest that dietary supplementation with taurine may have beneficial effects on mental focus and alertness and may assist during times of increased physical exertion.

Caffeine Anhydrous

Caffeine is one of the most widely consumed, and perhaps one of the most reviewed, psychoactive compounds. Its physiological effects in a range of areas have been well-documented, including exercise performance, information processing, alertness and mood enhancement, attention, and awareness, along with its anti-lipogenic and lipolytic abilities.

Most importantly to FURY BLACK, caffeine has been shown to have significant effects on exercise performance, even with ingestion in servings as small 3 to 9mg/kg/bw/day (the equivalent of 2 cups of standard coffee, for a 170lb male). In endurance training, possible explanations for caffeine’s performance-enhancing effects lie in its metabolic effects on both lean and fat tissue. It is suggested that caffeine’s potent lipolytic (the breakdown of fat tissue into fatty acids) and oxidative (the actual ‘burning’ of fat) action allow the body to utilize these sources during prolonged submaximal exercise. Consequently, muscle glycogen is spared and available for use later in the training session. Practically speaking, this means caffeine is forcing your body to preferentially use fat tissue as a fuel source, while sparing the glycogen which gives you the full-bodied look!

In short-term exercise, caffeine’s demonstrated role in the inhibition of cyclic AMP- phosphodiesterase’s (PDE), adenosine receptor antagonism, and adrenoreceptor agonism come into play. These three pathways stimulate lipolytic activity, boost fat metabolism, increase metabolic rate and energy expenditure, and regulate the body’s thermogenic activity. The practical results of activating these pathways are increases to the contractile force of both cardiac and skeletal muscle (harder flexion), an increase in energy expenditure (freeing up more caloric energy to be used in contraction), dilation of vasculature (better blood flow), and improvements to both nitrogen retention and skeletal muscle protein synthesis (key components to muscle building).

VasoDrive-AP (Isoleucyl-prolyl-proline (IPP) and Valyl-prolyl-proline (VPP) (from hydrolyzed milk casein)

Vasodrive-AP is a patented dietary supplement ingredient composed of a precise blend of naturally derived peptides, primarily derived from casein hydrolysate. This ingredient has garnered attention for its potential benefits in enhancing exercise performance through its vasodilatory properties. Vasodrive-AP works by promoting the release of nitric oxide (NO), a key signaling molecule involved in vasodilation, which leads to the relaxation of blood vessels and increased blood flow to exercising muscles. It does this through several mechanisms of action. First, the increase in the production of endothelial nitric oxide synthase (eNOS) improve arterial flexibility leading to enhanced blood flow. Second, Vasodrive-AP can also inhibit the enzyme that leads to the constriction of blood vessels. By improving blood flow and oxygen delivery to working muscles, Vasodrive-AP may enhance exercise capacity, delay the onset of fatigue, and improve overall performance during both endurance and resistance training activities. Additionally, the improved nutrient and oxygen delivery facilitated by Vasodrive-AP may aid in muscle recovery post-exercise, potentially reducing muscle soreness and accelerating the repair process. While further research is needed to fully elucidate its mechanisms and optimal dosages, Vasodrive-AP shows promise as a natural ergogenic aid for individuals seeking to maximize their exercise performance and recovery.

Cognizin Citicoline

Choline is an essential nutrient involved in numerous metabolic pathways, including DNA regulation and repair, protein function, and metabolism. Perhaps most importantly, the critical neurotransmitter acetylcholine is produced directly from free choline via cholinergic neurons. Acetylcholine is then responsible for several functions itself, most crucially as the compound which induces muscular contraction, and as the neuromodulator partially responsible for modulating risk/reward, arousal, and enhancing memory.

Choline’s essential role as a substrate for acetylcholine, and therefore brain development, is well documented in animal models. These studies demonstrate that levels of free maternal choline have a direct and fundamental impact on prenatal brain development, with the enhancements or deficits lasting into adulthood. Choline’s enhancing effect is particularly prominent in the hippocampus. In humans, the hippocampus is primarily involved in the consolidation of memory (taking short, episodic memory and translating it into long-term memory) and the learning of new information. Acetylcholine is a critical component in these processes, as mentioned above, and choline may therefore play a potential role in these processes as well by providing the substrate for acetylcholine synthesis.

Citicoline (Cytidine 5’-diphosphocoline), also known as CDP-choline, is a potentially superior form of choline due to its ability to cross the blood brain barrier. In fact, most studies with neurological or nootropic effects used this form. In that regard, studies in otherwise healthy, normal adults demonstrated meaningful and statistically significant impacts on working memory, recall, and attention. We have chosen to use the clinically tested, Cognizin, in this premium formula as our primary choline source. Unlike other synthetic stimulants that can cause a rapid decline in effectiveness after an initial burst of energy, Cognizin can offer critical nutritional support for the brain that can help support needed focus and attention.

Methylliberine (as 40% Dynamine yielding 60mg)

Dynamine (methylliberine) is a naturally occurring alkaloid structurally similar to the stimulant’s caffeine and theacrine. It is most widely known and utilized for its rapid onset of action, non-habit-forming properties, and ability to enhance energy, cognition, and mood without significant cardiovascular stimulation. Due to these characteristics, Dynamine has gained attention as a reliable and potential ergogenic aid in sports and exercise performance.

Dynamine works primarily through the mechanism of action of modulating adenosine receptors. This action is similar to caffeine but with a shorter half-life and reduced tolerance build-up. It also influences dopamine and noradrenaline levels, leading to enhanced mood and motivation. Unlike caffeine, Dynamine has been shown to provide a rapid onset of energy without the associated increase in blood pressure or heart rate, making it a safer alternative for individuals sensitive to stimulants.

When combined like in F Tyranny, Dynamine and caffeine can create a synergistic effect that enhances focus, energy, and mood. Dynamine can extends caffeine’s stimulatory benefits by inhibiting adenosine receptors while also influencing dopamine pathways, leading to heightened alertness and motivation. Additionally, Dynamine’s shorter half-life than caffeine, means it kicks in quickly and enhances the initial energy surge without significantly increasing heart rate or blood pressure rapidly.

To summarize Dynamine’s benefits for exercise performance:

• Enhanced Energy and Alertness
  Dynamine provides a rapid boost in energy by inhibiting adenosine, a neurotransmitter responsible for inducing fatigue. This allows athletes to experience heightened alertness and prolonged endurance during workouts.
• Increased Motivation and Mood
  By influencing dopamine levels, Dynamine can improve motivation and mood, leading to better mental engagement and workout consistency. This effect is particularly beneficial for individuals experiencing mental fatigue or lack of drive.
• Reduced Perceived Effort and Fatigue
  Studies suggest that Dynamine can reduce the perception of effort during physical activity, allowing users to train harder and longer, which is crucial for endurance sports and high-intensity training sessions.
• Synergistic Effects with Caffeine and Theacrine
  When combined with caffeine or theacrine, Dynamine enhances the stimulatory effects without increasing jitters or crashes. This combination provides sustained energy levels, improved reaction times, and enhanced cognitive function during events.
• Minimal Cardiovascular Impact
  Unlike traditional stimulants, Dynamine does not significantly increase heart rate or blood pressure, making it a safer option for athletes looking for an energy boost without excessive strain on the cardiovascular system.

ZümXR Extended Release Caffeine (yields 70% caffeine)

Züm-XR is a patented coating technology that allows the dissolution profile of certain ingredients, primarily caffeine, to have a longer lasting effect in blood serum levels. The release of those ingredients is initiated by an abrasion in the stomach and pH levels between the stomach and the upper gastrointestinal tract. The coating of the microbead technology is a patented timing system with pharmaceutical grade safe polymers. Comparatively speaking, the dissolution profile of Züm-XR caffeine to your typical immediate release caffeine showed that Züm-XR took a far greater amount of time, well over 120 minutes to complete the process of dissolution.

Ioniplex Trace Mineral Complex

Our bodies are high-functioning machines and require a lot of support to continue to perform at a high-level day in and day out. A lot of these needs are difficult to acquire by dieting alone, so supplementation is critical. Minerals are included in these daily needs and are vital to the bodies’ many processes.

Ioniplex is a patented and clinically tested high-quality trace mineral complex providing a comprehensive blend of nutrients that are often hard to acquire from diet alone. Containing 65+ ionic trace minerals, its high bioavailability allows each mineral to penetrate cellular membranes easily to allow for the transport of nutrients directly to the cell structures for maximal absorption. Ioniplex also actas as a natural chelator, meaning it can bind up toxic compounds, heavy metals, and other foreign substances to transport out of the cells so your essential body cells can continue to thrive.

Minerals contained in Ioniplex are catalysts for all of the vitamins and other nutrients our body requires to function at an optimal level and maintain health. Some of these functions include electrolyte replacement, maintaining pH balance in the body, nourishing hair and skin, strengthening bones and joints, regulating the digestive system, and improving athletic performance.

Clinical studies have shown that Ioniplex has been a contributing factor to:

• stimulating mitochondrial activity by nearly 35%
• Stimulating key gene expression involved in mitochondria metabolism including energy production 200%-370%
• Increasing production of type I collagen over 40%
• Increasing production of beneficial bacteria while inhibiting pathogenic bacteria
• Reduce excess glucose in the bloodstream by up to 75%

We demand a lot from our bodies and expect high performance on the outside, why not expect the same of our bodies on the inside.

Bitter Orange Extract (Citrus aurantium) (Fruit) (30% synephrine)

Bitter orange extract, derived from the fruit of Citrus aurantium, contains a diverse array of bioactive compounds, notably including synephrine, flavonoids, and essential oils. Synephrine, the principal alkaloid in bitter orange extract, exhibits sympathomimetic properties, stimulating the sympathetic nervous system and potentially increasing heart rate, blood pressure, and metabolic rate. These effects have led to interest in bitter orange extract as a potential aid for weight management, with studies suggesting its ability to enhance thermogenesis, suppress appetite, and stimulate lipolysis.

The flavonoids present in bitter orange extract contribute antioxidant activity, which may offer additional health benefits by protecting cells from oxidative damage. Additionally, the combination of caffeine and synephrine appears to potentiate each ingredient’s effects – with rates of fatty acid liberation, heart rate, metabolic rate, and fatty acid oxidation increased in clinical trials featuring the combination. In several studies utilizing other forms of synephrine, it was found that the combination of synephrine and caffeine led to a small but significant reduction in fat mass of 3lbs, and a reduction in bodyfat of 2.9%.

Rauwolscine (std. to 90% alpha yohimbine) (Root)

Alpha Yohimbine, also known as rauwolscine, offers several potential benefits, particularly in the realm of sports performance as well as weight management. As a dietary supplement, it is often touted for its ability to enhance fat loss and promote energy expenditure, making it popular amongst many athletes.

Alpha Yohimbine exhibits a mechanism of action that works to antagonize alpha-2 adrenergic receptors, which can lead to increased lipolysis, which is the breakdown of stored fatty acids that can then be used as a fuel source for the body. This utilization of fatty acids for energy can support weight loss and management, thus improving overall body composition.

It’s essential to note that while Alpha Yohimbine shows promise, more research is needed to fully understand its effects.

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