Letrone + Viron "The AI/Test Boosting Stack By Black Lion Research
Letrone by Black Lion Research
Letrone by BLR , Powerful Anti-Aromotase Protection
Black Lion Research is proud to announce the release of Letrone the latest innovation in aromotase inhibition. This product is a natural anabolic aromatase inhibitor.
Atractylodes macrocephala Koidz (A. macrocephala), a Chinese medicinal herb, has been extensively used to treat digestive diseases in China and most other Asian countries (PPRC, 2005; Lee et al, 2007). Dry rhizomes of A. macrocephala are rich in sesquiterpenes and acetylenic compounds (Endo et al, 1979; Chen 1987; Huang et al, 1992; Lin et al, 1997). Typical polysaccharides atractan A, B, and C, present in A. macrocephala, have been reported to exhibit hypoglycaemic activities (Wang et al, 2000; Jia et al, 2003). Although atractylenolide I, atractylenolide II and atractylenolide III are all bioactive substances present in Atractylodes macrocephalae, the majority of research studies carried out in the recent years have focused on atractylenolide II and atractylenolide III (Kang et al., 2011b). Atractylenolide II is a marker substance present in Atractylodes macrocephalae which exhibits well-documented gastrointestinal inhibitory effects and anticancer activity (Zhang et al., 1999; Liu et al., 2005). Atractylenolide II is one of the main constituents present in the effective volatile oil fraction (Li et al., 2001), potentially effective in treating senile dementia. Atractylenolide III is a possible candidate for the treatment of human lung carcinoma (Kang et al., 2011a).
Primary targets for aromatase inhibition are atractylenolide 1 2 and 3 with atractylenolide 1 being exceptionally strong with 94.5% inhibition.
Abstract:Ten compounds were isolated from the dichloromethane extract of Atractylodes
macrocephala and their aromatase inhibiting activities were tested using an in vitro
fluorescent-based aromatase assay. The results indicated that atractylenolide I (1),
atractylenolide II (2) and atractylenolide III (3) had inhibition ratios of 94.56 ± 0.70%,
90.93 ± 1.41% and 86.31 ± 8.46%, respectively, at a concentration of 10 μM. We conclude
from our results that atractylenolide and its derivates may serve as potential aromatase
inhibitors (AIs) and thus merit continued study in the future.
Atractylenolides are exceptionally strong aromatase inhibitors that show exceptional oral bioavailability. There are many AIs in nature. During my research I must have found over 100 potentials but unfortunately 99.9999% of them are poorly absorbed orally which limits their potential.
Atractylenolide in contrast is very well absorbed.
-"Atractylenolide I is absorbed quite well at all segments of intestine in rats and no specific absorption was founded in different segment."
-"Atractylenolide I can be classified into high penetrating drug. Passive diffusion dominates the absorptive transport behivior of atractylenolide I. Atractylenolide I can be absorbed in the whole intestinal segments and there is not a preferntial absorption zone in the intestine. The absorption and secretion of atractylenolide I are mediated by the efflux transport system, P-gp."
The intestinal permeability of three sesquiterpene lactones, atractylenolide I, II, and III, was investigated using the human Caco-2 cell monolayer model. The bidirectional permeability of the three compounds from the apical (AP) to the basolateral (BL) side and in the reserved direction was studied. The three compounds were assayed using HPLC. The P app values of atractylenolide I, II, and III were all at the level of 10 -5 cm / s, suggesting high intestinal permeability and good absorption. The bidirectional transport of the three compounds was time- and concentration-dependent, and indicated the main mechanism of the passive diffusion of the three compounds across the intestinal epithelium membrane. Moreover, atractylenolide I might be partly actively transported. "
It was a huge loss when Formeron got canned because well....Ais are great but formestane was also anabolic.
Letrone is a stout AI but it also shows significant anabolic potential by increasing endogenous hormones.
In one animal study growth was increased by 20% compared to control when animals were fed polysaccharides of atractylodes macrocephala.
The increase in growth was attributed to increases in-
Growth hormone x30%
"Comparing to the control group,the PAM group increased the average gain weight by 20.72%"
"increased the levels of growth hormone(GH),insulin-like growth factor-I(IGF-I),3,5,3′-triiodothyronine(T3),3,5,3′,5′-tetraiodothyronine(T4) and cyclic adenosine monophosphate(cAMP) in serum by 30.77%(P0.05),52.02%(P0.05),47.60%(P0.05),36.70%(P0.05) and 21.15%(P0.05),respectively.The results indicated that PAM improved the growth performance of weaned piglets through the endocrinal system.Furthermore,it is possible that PAM altered the growth performance of weaned piglets by up-regulating the synthesis and secretion of GH,IGF-1,T3,T4 and cAMP."
Finally, Atractylodes macrocephala potentiates Ghrelin secretion and receptor signaling. Ghrelin increases hunger and Growth hormone secretion.
Now you have not only an exceptionally strong oral AI but one that has serious anabolic potential.
Viron by Black Lion Research
High grade Eurycoma longifolia (EL) extract plus Boron citrate
Eurycoma longifolia Jack (Tongkat ali, Pasak bumi) is a plant native to Indonesia, Maylasia, Thailand, and vietnam. Raw plant material and extract have been used for centuries as a tonic for libido and sexual function. Studies indicate that it has tons of properties beneficial to the bodybuilder or weight trained athlete. Anyone who trains seriously knows what testosterone is and its vital importance to performance, strength and muscle gain not to mention libido and confidence and everything male. Lots of people don’t realize though that much of your Total testosterone is bound up and unusable. The majority of your test is bound to SHBG (Sex Hormone Binding Globulin). SHBG is a glycoprotein that binds to sex hormones, androgen and estrogen. Anything bound by SHBG is not available to bind to androgen receptors which is where we want it. EL raises testosterone levels, helps to manage estrogen, reduces cortisol and improves quality of life. Not all EL is equal though and we took great care to ensure we have the best possible extract that is only used by us. Many El products are fake, poor extracts or even just ground up plant material. Some are spiked with drugs like viagra or stimulants which may be harmful to your health. Our EL is the highest possible quality and will always be the best EL available for any price.
EL has been shown to have the following potential effects:
- Boosts testosterone
- Increases luteinizing hormone
- Promotes erection
- Reduces SHBG
- Increases Free testosterone
- Decreases cortisol
- Decreases estrogen
- Increased muscle mass
- Improved sexual performance
- SERM properties
EL is a star component to Viron but it’s not alone. We also include 10mg Boron citrate.
Boron is a natural trace mineral that many people are deficient in. Boron has the potential to increase your FREE testosterone to levels high enough to create an abnormally anabolic environment. Even if your total testosterone levels are in normal ranges if your free test is very high it will be similar to total test being super high as its the free portion that really matters.
BORON CITRATE PROPERTIES INCLUDE
- Increases Free testosterone
- Increased DHT
- Increased Vitamin D
- Decreases inflammation
- Increased muscle mass
- Improves joints
- Strengthens bones
- Reduces estrogen
- Lowers plasma lipid levels and enables removal of cholesterol through various means.
- Enhanced cognitive function. Hand eye coordination, Short term memory and concentration.
Viron is a great supplement for:
On natty supp cycles to keep test levels up and for the huge increase in free T. Also just for the added health benefits of both EL and Boron.
Off cycle for increased test levels and to keep SHBG low. Lots of guys like to take EL year round for its mood and libido enhancing properties and many people are boron deficient.
It is especially good for PCT. You could run the Viron and Formeron for PCT with no other additions. Post cycle your system is a mess. Aside from the obvious benefit in PCT of raising test and free test EL acts like a SERM similar to tamoxifen (novadex). In addition you get reduced inflammation and improved lipid profile (lipids are normally extremely bad after any oral steroid or prohormone). Furthermore you will benefit from the reduction in cortisol and general mood improvement everyone needs during PCT.
Combines with Formeron it makes a perfect PCT.
EL increases testosterone
EL decreases cortisol
EL increases LH
EL decreases estrogen.
While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Nutriverse assumes no liability for inaccuracies or misstatements about products.