VEIN POPPING PUMPS
What To Expect From Han Swolo:
- Anti inflammatory
- Prevents oxidative stress
- Prevents muscle atrophy
- Reduces blood glucose
- Reduces bodyfat
- Increases insulin sensitivity
- Increases energy output
The purpose of a pre workout supplement is to improve performance but these days pre workout products have become nothing more than massive stimulant bombs. This constricts blood vessels and prevents blood, oxygen and nutrients from reaching the muscles at the most crucial time. Han Swolo has no stimulants. Instead it is full of ingredients that inflate your blood vessels to the absolute max which helps deliver needed nutrients for growth and oxygen for performance and strength. Han Swolo delivers performance enhancement not over stimulation. Shirt tearing, vein popping pumps.
Ligustrazine is a natural compound isolated from TCM (Traditional Chinese [herbal] medicine) Ligusticum wallichii (Chuan Xiong), which has been extensively used for medicinal purpose for more than 2000 years. Ligustrazine was firstly isolated in 1957 and has been increasingly studied for its action on myocardial and cerebral infarction since 1970s. In the past decades, researchers explored other pharmacological capabilities of Ligustrazine in various diseases, such as coronary heart disease, diabetes, cancers, and liver injury. Accordingly, laboratory study verified the regulation ability of this agent in multiple molecular targets, such as anti-inflammation, antioxidant, antiplatelet, and antiapoptosis. The pharmacology of Ligustrazine has been well reviewed.
The cardiovascular pharmacological effects of Ligustrazine aroused widespread interest among researchers in recent years. There are considerable documents supporting the view that this monomer can be a promising botanical remedy for cardiovascular diseases. The possible mechanism of its action might include modulating ion channels, stimulating the release of NO production, inhibiting vascular smooth muscle cell proliferation and migration, scavenging ROS, regulating inflammation and apoptosis, and preventing platelet aggregation.
Ligustrazine has a bioavailability of around 10% and experiences rapid clearance giving it a very short half life. This makes is unsuitable for supplemental usage without modification. The phosphate addition increases bioavailability to around 87% vs 10% and the inhibitor quercetin co-crystals prevents its rapid metabolism increasing half life many times over.
Combined this makes our Ligustrazine phosphate the strongest version available and makes this stuff one hell of a vasodilator and performance enhancer.
Ligustrazine phosphate is a fantastic nitric oxide booster but works in multiple ways to open blood vessels. Testing indicates it is effective even in the presence of stimulants. It is also slightly anabolic and prevents muscle atrophy. Ligustrazine reduces oxidative stress and reduces inflammation making it a fantastic addition.
OSTHOLE CYCLODEXTRIN COMPLEX
Osthole is a coumarin commonly found in Cnidium monnieri. Cnidium has been used for thousands of years in tradition Chinese medicine (TCM) for anti-viral properties, skin rashes and breakouts, as pro-erectile agents, anti-osteoporotic as well as anti-diabetic and sometimes anti-inflammatory. Studies indicate that if bioavailability is enhanced osthole can be an exceptional vasodilator and will work in spite of CNS stimulant usage.
Osthole has a somewhat low oral bioavilability along with a very low water solubility and experiences rapid first pass metabolism. A limited percentage is absorbed and of this limited percentage 40% is gone at 5 min and at least 80% of that osthole is metabolized within 20 min. As such we have taken steps to ensure the our osthole actually works. We have employed an osthole cyclodextrin complex with the addition of a strong metabolic inhibitor (quercetin niacin co crystals). Our bioavailable Quercetin has a strong inhibitory effect against CYP2D6 and a moderate effect against CYP2C19 and CYP3A4 helping to prevent the rapid metabolism plaguing normal osthole. As a result we see massively increased bioavailability, water solublity and major inhibition of first pass metabolism. Black lion Research Osthole has fantastic bioavilability with a long half life.
Bioavailability was the limiting factor for osthole and the reason it has such lackluster effects. BLR Osthole cyclodextrin is some awe inspiring stuff and results in serious vasodilation, clearing its main hurdle (oral availability).
Osthole has the capability to dilate blood vessels and arteries even in the presence of CNS stimulants.
It is concluded that osthole relaxes rat thoracic aorta by virtue of its Ca(2+)-channel blocking properties and by elevating cGMP levels in vascular smooth muscle. Osthole has also been shown to work well in the presence of stimulants so if you do choose to add some stims to your pre workout mix you will still get great vasodilation and pump.
Additional Benefits of Osthole:
- Insulin sensitivity
- Helps reduce fat
- Helps increase energy output
AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular metabolism. Activation of AMPK in skeletal muscles, the liver, and adipose tissues results in a favorable metabolic milieu for decreased levels of circulating glucose, plasma lipids, and ectopic fat accumulation and enhanced insulin sensitivity. Osthole increases AMPK and increases GLUT4 expression which helps keep glucose down, insulin sensitivity up and fat loss at a maximum level.
Osthole is a also dual PPAR agonist and improves glucose and lipid metabolism via modulation of PPARα/γ-mediated target gene expression in liver, adipose tissue, and skeletal muscle. During a 9 week treatment with osthole emulsion, Lipid levels in serum and liver were decreased by 37.9–67.2% and 31.4–38.5% for triglyceride, 33.1–47.5% and 28.5–31.2% for free fatty acid, respectively, the fasting blood glucose, fasting serum insulin, and homeostasis modelassessment of IR were also decreased by 17.2–22.7%, 25.9–26.7%, and 37.5–42.8%, respectively.
Osthole has been shown to improve glucose and lipid metabolism and exert a significant effect on fat loss.
Osthole has once been implicated in increasing testosterone, as well as luteinizing hormone and FSH.
Quercetin Niacin co crystals
Everyone knows about quercetin and niacin but quercetin has very poor oral bioavailability ~1% and niacin causes severe flushing at decent doses. Bonding the molecules together increases the absorption of Quercetin many times over ~40-70%, and prevents the Niacin flush. Quercetin is an exceptional vasodilator as is Niacin and quercetin has been studied for everything from endurance and an increase in VO2 Max, fat loss, its strong antioxidant effect, and its antiviral power, however, for our purpose we added it for more than just vasodilation.
Both Ligustrazine and Osthole have exceptionally rapid first pass metabolism giving them very short half lives. Quercetin has been shown to inhibit the metabolism of both giving them vastly improved half-lives and oral efficacy.