Applied Nutriceuticals IGF-2

Immediate
Growth
Factor!*

•SUPPORTSNORMAL IGF-1 LEVELS AND GHRATIOS *

What is IGF-2 and
What Does it Do?

IGF-2 is a powerful anabolic blend of some of the strongest herbal anabolic compounds on the market;* precisely formulated and dosed to support muscle building goals!*. It supports natural growth hormone and testosterone production within normal levels.*

The basics of IGF-2

• Stimulates natural growth hormone and testosterone production within normal levels.*
• Supports testosterone levels to promote sexual health and muscle hardness*
• Supports increases in HGH levels within a normal range.*
• Supports healthy testosterone levels within a normal range.*

What makes IGF-2 one of the Most Effective
GROWTH PRODUCTS We’ve Ever Made?

The ingredients in IGF-2, precisely blended to optimal ratios together produce a powerful synergistic combination. Synergism of hormones occurs in situations where more than one hormone produces the same effects at the target cell, and their combined effects are amplified.

MUCUNA & CHLOYOPHYTUM

The two principle components of IGF-2, Mucuna Pruriens and Safed Musli (Chlorophytum Borivillanum), are a potent testosterone and Growth Hormone (GH)-boosting combination.* Mucuna Pruriens may support natural testosterone production through inhibiting prolactin and thereby increasing luteinizing hormone (LH) levels.* Prolactin is a hormone that has a regulatory role over gonadotrophic hormone secretion, meaning that it can suppress the action and release of these important hormones. This is important because gonadotrophic hormones control the entire process of male testosterone production, and luteinizing hormone (a gonadotrophic hormone directly responsible for spermatogenesis and natural testosterone production) is a key factor in the control of endogenous male androgen production. Prolactin can directly suppress the secretion of luteinizing hormone, an action that can hinder natural testosterone production significantly, thus not allowing optimal levels of the hormone to be produced by the testes. By inhibiting prolactin, Mucuna Pruriens supports endogenous testosterone levels, promoting increased lean body mass gains and better recovery.*

Furthermore, the ethanolic and sapogenic extracts of Chlorophytum have been suggested in animal studies to support an increase in testosterone and body weight* Chlorophytum seems to act as a phytoandrogen (an herbal substance that acts on the androgen receptor), and anecdotal data from products containing this compound also point to supporting testosterone levels and lean body mass.* While the mechanism of action for Chlorophytum is poorly understood, and more research on the compound must be conducted, it seems to act in a manner very similar to testosterone, in both terms of strength and lean body composition.* (1,3,4-6,10,23-29)

DODDER SEED & RHODIOLA

Dodder Seed is another important component of IGF-2 as it also activates the second messenger system, and subsequently causes adenylate cyclase to generate cAMP from ATP. cAMP generation has a variety of effects on tissue and glandular activity, but the most notable is the stimulation of the thyroid to produce thyroxin (promoting elevated fat burning). Increased cAMP levels also activate the protein kinase enzyme, which in turn activates hormone-sensitive lipase (HSL) in targeted tissues and signals for the production of luteinizing hormone, which supports testosterone levels in males.* Elevations in these two hormones can cause a marked increase in fat as body fuel, as well as a strong correlation to decreased body fat and increased muscle mass, density and strength.*

The rosavin and salidroside content of Rhodiola Rosea has also been suggested to support a healthy stress response in humans by promoting healthy cortisol levels, while optimizing levels of key brain chemicals such as serotonin and dopamine that function together to maintain a healthy response to stress.* Supporting healthy cortisol is a very important effect, as cortisol breaks down muscle tissue and increases body fat, slowing the metabolism and lowering immune function. Rhodiola has been suggested to also have adaptogenic qualities, allowing the human body to work harder during stress, while at the same time maintaining higher energy reserves.* This is important to hard-training because intense stress and strain can cause significant increases in stress hormone levels like cortisol, thus diminishing results. (1-3,8-9,11-19,21-23)

For Maximum Results, What Does
IGF-2 Stack Best With?

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• Singh R, Artaza WE, Taylor WE (2005) Testosterone inhibits adipogenic differentiation in 3t3-L1 cells: nuclear translocation of androgen rec. complex w/ catenin. Endocrinology 16210377
• Hikim, Bashim, Taylor (2004) Androgen Receptor in Human Skeletal Muscle and CultuBlue Muscle Cells: Up regulation by androgen treatment. The J. of Clin. Endo. And Metab. 89: 5245-5255.
• Kaushik, N (2005) Saponins of Chlorophytum Species.Phytochemistry Reviews. 4(2-3): 191-196.
• Rath, S (2003) Botanical source of safed musli. Sachitra Ayurved.55(11): 866-869.
• Deepak and Bhatnagar (2004) Pharmacognostical evaluation of Chlorophytum borivillanum root, Ancient Science of Life. 24(1): 30-37.
• Jensen MD (2003) Effects of growth hormone administration on human obesity. Obes. Res. 11(2). 170-5.
• The thyroid gland. Endocrinology: An Integrated Approach by Stephen Nussey and Saffron Whitehead (2001). Published by BIOS Scientific Publishers Inc.
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• Rathi SS, Grover JK, Vats V. (1999) The effect of momordica charantia and Mucuna pruriens and their effect on key metabolic enzymes involved in carbohydrate metabolism. Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
• Parikh et al, (1990) Indian Drugs. Chem Abs 27: 353.
• Ahmad S et al (1991) Conference of Pharmacology and Simposium on Herbal Drugs (New Delhi), March 1991, 15:26.
• Manyam BV (1995) J. Altern. Completment Med. Fall. 1(3) 244-255.
• Takahashi Y, Kipnis M, Daughaday WH (1968) Growth hormone secretion during sleep. J Clin Invest 47(9): 2079-2090.
• Kar A, Panda S, Bharti S (2002) Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J Ethnopharmacol 81(2): 281-85.
• Saratikov AS et al. (1987). Rhodiola Rosea is a valuable medicinal plant (Golden Root). Tomsk, Russia: Tomsk State UniversityPress.
• Sandberg F (1998) Herbal Remedies and Herbal Magic. Stockholm, Sweden: Det Basta; p. 223.
• Narr H, (1993) Phytochemical and Pharmacological investigation of the adaptogens: Rhodiola crenata and Rosea {dissertation}. Munich, Germany: Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-Universtat MYchnen.
• Salnik BU (1970) Effect of several stimulators on central nervous system energy metabolism during muscular workload {dissertation}. Tomsk, Russia: Tomsk State Medical Institute.
• Adamchuk LB (1969) Effects of Rhodiola on the process of energetic recovery of rat under intense muscular workload {dissertation}. Tomsk, Russia: Tomsk State Medical Institute.
• Revina TA (1969) Effect of stimulators of the central nervous system on carbohydrate and high energy phosphorylated compound metabolism in the brain during intense muscular workload {dissertation} Tomsk, Russia: Tomsk State Medical Institute.
• Wang, H (1998) Analysis of Dodder seed- A review of literature. Biomed Chromatogr 12(1): 27-30.
• Courtesy of Ergo-Light.com. The Pathway Page. Biosythesis of Androgens and Estrogens.
• Berdanier, Carolyn D.; Dwyer, Johanna T.; Feldman, Elaine B. (2007). Handbook of Nutrition and Food. Boca Raton, Florida: CRC Press.
• Thakur M. and Dixit V.K.* EFFECT OF CHLOROPHYTUM BORIVILIANUM ON ANDROGENIC & SEXUAL BEHAVIOR OF MALE RATS Indian Drugs 2006 April 43(4): 300-306
• Kothari S.K., Safed Musli (Chlorophytum borivilianum) revisited,Journal of Medicinal and Aromatic Plants. 2004, 26, 60-63.
• Saxena S and Dixit V.K: Role of total alkaloids of Mucuna pruriens Baker in male rats, Indian Journal of Natural Products. 1987, 3(2), 3-7.
• Unnithan A.R. and Tandon V.L: Role of growth hormone in spermatogenesis in male rats. Indian Journal of Experimental Biology.1982,20,734-737.
• Modi KP, Patel NM, Goyal RK. Estimation of L-dopa from Mucuna pruriens LINN and formulations containing M. pruriens by HPTLC method Chem Pharm Bull (Tokyo). 2008 Mar: 56(3): 357-359.
• Tharakan B, Dhanasekaran M, Mize-Berge J, Manyam BV. botanical Mucuna pruriens prevents levodopa induced plasmid and genomic DNA damage.Phytother Res. 2007 Dec;21(12):1124-6.