Serving Size: 4 DRCaps™ | ||
Servings Per Container: 20 | ||
Amount Per Serving | % DV * | |
Vitamin C (as Ascorbic Acid) | 90mg | 150% |
Vitamin D (as Cholecalciferol) | 1,200IU | 300% |
Vitamin K2 (as MK-4) | 160mcg | 200% |
Vitamin B6 (as Pyridoxal-5-Phosphate) | 2mg | 100% |
Folate (Folic Acid) | 800mcg | 200% |
Vitamin B12 (as Cyanocobalamin) | 12mcg | 200% |
Selenium (as Sodium Selenite) | 70mcg | 100% |
Somatophasic EX Terafusion™ | 1,753mg | |
Safed Musli (Chlorophytum borivillanum) (root) (70% Saponins) | * | |
Velvet Bean (Mucuna pruriens) (fruit)(standardized to 75% L-Dopa) | * | |
P2Y2-Nootropil Composite™ | 411mg | |
Choline (as Choline Bitartrate) | * | |
Uridine-5-Monophosphate | * | |
Toothed Club Moss (Huperzia serrata) (aerial)(as Huperzine-A 1%) | * | |
Meta-Factorial Anti-DC Mechanism™ | 570mg | |
Green Tea (leaf)(standardized to 98% Polyphenols, 45% EGCG) | * | |
* % Daily Value (DV) is based on a 2,000 calorie diet. Your daily values may be higher or lower based on your calorie needs.
† Daily Value (DV) not established. |
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Other Ingredients: Hypromellose (DRCaps™), Magnesium Stearate, Titanium Dioxide |
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Directions: Take 4 DRCaps™ at bed time on an empty stomach or with a slow-releasing protein and 12 oz. of fluid. For best results, take HG4Up™ in a 5 days on/2 days off dosing format. |
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Warnings: DO NOT USE IF PREGNANT, NURSING, OR UNDER THE AGE OF 18. KEEP OUT OF REACH OF CHILDREN. Do not exceed recommended serving. Consult with a health care practitioner before taking this or any dietary supplement, especially if you have or suspect you may have a medical condition, or are taking ANY medications, over the counter products, or other dietary supplements. Immediately discontinue use and call your health care provider. Store at room temperature and avoid excessive heat. KEEP OUT OF REACH OF CHILDREN. DO NOT USE IF INNER SEAL IS BROKEN OR MISSING. |
HG4-UP is engineered to help Maximize:
Deep Recovery-
Enhancing Sleep*
Plate-Pounding
Strength*
Ripped Muscle Mass*
You don’t have to max out every time you hit the gym, but you do need to maximize what you put into your body every day to reach your power potential. HG4-Up is new from Applied Nutriceuticals and supports increases in GH levels within normal ranges, which helps maximize deep, restful sleep.* Reinvigorated sleep from HG4-Up helps support muscle growth for amplified strength and endurance gains, as well as increasing muscle size and hardness when used in combination with a healthy diet and exercise.*
We took our best-selling product HGH Up and made it more effective with the combination of “3” complexes:
- Somatophasic Ex Terafusion
- P2Y2 Nootropil Composite
- Meta-Factorial Anti-DC Composite
APPNUT Athlete Jerry Greer
Doug Jantz Photography
In addition to the grouping of “3” complexes that symbiotically work together to maximize results, our revolutionary new HG4-Up formula utilizes several new innovations from our original HGH-Up formula.
- Enteric Capsule Coating—delays the release of the ingredients in HG4-Up. This helps utilize the initial powerful surge of natural GH that occurs in the first 90 minutes of sleep, while allowing for a secondary effect from the supporting GH-releasing ingredients present in HG4-Up(1-2).*
- P2Y Activators—HG4-Up contains ingredients that support acetylcholine levels. Enhanced acetylcholine levels are associated with enhanced GH levels(8-17).*
//P2Y2 Nootropil Composite
Uridine
Uridine is a purine nucleotide base found in multiple natural sources. It is a potent activator of purinergic receptors (mainly PY2) and supports phosphocholine levels.* P2Y receptors are closely associated with growth factor production, blood flow, and anabolic signaling(8-13).*
Choline
Choline is a molecule that is used in methylation and the production of acetylcholine. Studies have shown a synergism between uridine and choline in the support of phosphocholine and CDP-Choline. Increases in CDP-Choline are associated with supporting the effectiveness of trophic hormones such as GH(18-20).
//Somatophasic EX Terafusion
L-Dopa (from Mucuna pruriens)
L-Dopa has been shown to supports levels of growth hormone in human subjects in an orally viable manner. L-Dopa is most effective when the conversion of L-Dopa to dopamine is mediated by a decarboxylase inhibitor (EGCG) (24-28).*
Mucuna Pruriens & Chlorophytum Borivillanum
The combination of Mucuna and Chlorophytum has been shown by a recent human study to support GH levels(29).*
Vitamin B6
Vitamin B6 may support the night-time peak of GH, while at the same time increasing the rise in GH associated with exercise by 23%(30-31).*
//Meta-Factorial Anti-DC Composite
Green Tea Extract & EGCG
(−)-epigallocatechin-3-O-gallate (EGCG), which is found in high amounts in the green tea extract, has been shown in several studies to be an irreversible inhibitor of Dopa decarboxylase. EGCG has been shown to significantly increase the effects of Huperzine A on acetylcholine esterase inhibition by increasing the transport of Hup-A by serum albumin(32-33).
Normal GH pulses occur throughout the day. During a typical day, there are 10 pulses of GH secretion lasting on average 96.4 minutes with 128 minutes between each pulse. However, the largest GH pulse occurs during stages 3 and 4 of the sleep cycle. GH pulses during sleep occur at nearly triple the rate of GH pulses during the day (26-27).
- Maintain a healthy diet and lifestyle
- Drink plenty of water, at least 100 oz. per day
- Ingest at least 1 gram of protein per lb. of body weight daily
- Sleep at least 7 hours per night
- Eat plenty of fruits and vegetables
- Eat plenty of complex carbs
- Eat 5-6 smaller protein and carb-rich meals throughout the day
- Increase calories to at least 500 cal/day over your normal intake
- Stacking BCAAs and Creatine with HG4 may be helpful
- Avoid alcohol and tobacco
References
- Capsugel Media Library- Hypromellose Capsules http://capsugel.com/media/library/BAS415_hypro2_23802_V01_10-19-11.pdf
- Malah et al Hard Gelatin and HPMC (Hypromellose) Capsules: estimation of rupture time by real-time dissolution spectroscopy Drug Dev and Ind Pharmacy; 02/2007 33(1)27-34.
- Stokes et al The growth hormone response to repeated bouts of sprint exercise with and without suppression of lipolysis in men. J. Appl Physiol (1985). 2008 Mar;104(3):724-8. doi: 10.1152/japplphysiol.00534.2007
- Cansey et al Oral uridine-5'-monophosphate (UMP) increases brain CDP-choline levels in gerbils. Brain Res. 2005 Oct 5;1058(1-2):101-8. Epub 2005 Aug 29.
- Agarwal et al Short-term administration of uridine increases brain membrane phosphor lipid precursors in healthy adults: a 31-phosphorus magnetic resonance spectroscopy study at 4T. Bipolar Disord. 2010 Dec;12(8):825-33. doi: 10.1111/j.
- Babb et al Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study. Psychopharmacology (Berl). 2002 May;161(3):248-54. Epub 2002 Mar 22.
- Pooler et al Uridine enhances neural outgrowth in nerve-growth differentiated PC12. Neuroscience. 2005;134(1):207-14.
- Erb et al An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(o)-mediated signal transduction. J Cell Biol. 2001 Apr 30;153(3):491-501.
- Wang et al Dietary uridine-5'-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats. J Mol Neurosci. 2005;27(1):137-45.
- Kelijman M, Frohman LA. The role of the cholinergic pathway in growth hormone feedback. J Clin Endocrinol Metab. 1991 May;72(5):1081-7
- Liang YQ, Tang XC. Comparative studies of huperzine A, donepezil, and rivastigmine on brain acetylcholine, dopamine, norepinephrine, and 5-hydroxytryptamine levels in freely-moving rats. Acta Pharmacol Sin. 2006 Sep;27(9):1127-36
- Giustina A, Bossoni S, Bodini C, Doga M, Girelli A, Buffoli MG, Schettino M, Wehrenberg WB. The role of cholinergic tone in modulating the growth hormone response to growth hormone-releasing hormone in normal man. Metabolism. 1991 May;40(5):519-23
- Wang R, Yan H, Tang XC. Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine. Acta Pharmacol Sin. 2006 Jan;27(1):1-26
- Li YX, Zhang RQ, Li CR, Jiang XH. Pharmacokinetics of huperzine A following oral administration to human volunteers. Eur J Drug Metab Pharmacokinet. 2007 Oct-Dec;32(4):183-7.
- Haigh JR, Johnston SR, Peppernay A, Mattern PJ, Garcia GE, Doctor BP, Gordon RK, Aisen PS. Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase. Chem Biol Interact. 2008 Sep 25;175(1-3):380-6.
- Matsuda et al Insulin-induced hypoglycemia, L-dopa and arginine stimulate GH secretion through different mechanisms in man Regul Pept. 1990 Oct 29;31(1):53-64.
- Page et al Growth hormone responses (GH) to L-Dopa and L-arginine alone and after GHRH pretreatment. Clin Endocrinol (Oxf). 1988 May;28(5):551-8.
- Tapanainen P et al Variable plasma growth hormone (GH)-releasing hormone and GH responses to clonidine, L-dopa, and insulin in normal men. J Clin Endocrinol Metab. 1988 Oct;67(4):845-9
- Perlow et al Release of human growth hormone, follicle stimulating hormone, and luteinizing hormone in response to L-dihydroxy-phenylalanine (L-dopa) in normal man. Dis Nerv Syst. 1972 Dec;33(12):804-10.
- Boden G, Lundy LE, Owen OE. Influence of levodopa on serum levels of anterior pituitary hormones in man. Neuroendocrinology. 1972;10(5):309-15.
- Alleman et al., A Blend of Chlorophytum Borivilianum and Velvet Bean Increases Serum Growth Hormone in Exercise-Trained Men. Nutrition and Metabolic Insights 2011:4 55–63 doi: 10.4137/NMI.S812.
- Pyridoxine (Vitamin B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise. 1982 Aug 12;307(7):444-5.
- Barletta C, Sellini M, Bartoli A, Bigi C, Buzzetti R, Giovannini C Influence of administration of pyridoxine on circadian rhythm of plasma ACTH, cortisol prolactin and somatotropin in normal subjects. Boll Soc Ital Biol Sper. 1984 Feb 28;60(2):273-8
- Xiao J, Chen X, Zhang L, Talbot SG, Li GC, Xu M. Investigation of the mechanism of enhanced effect of EGCG on huperzine A's inhibition of acetylcholinesterase activity in rats by a multispectroscopic method. J Agric Food Chem. 2008 Feb. 13:56(3) 910-915.
- Zhang L, Cao H, Wen J, Xu M. Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin.