the gym.
USPLabs Pink Magic Ingredients:
Nelumbo nucifera (stem and leaves) and Rhamnus nakaharai (stem)
These plants have a wide range of potentially exciting properties...
Certain compounds present in these plants have been shown to inhibit various subtypes of phosphodiesterase, an enzyme (technically, a class of enzymes) which degrades cAMP (cyclic adenosine monophostphae) and cGMP (cyclic guanosine monophosphate), cyclic nucleotide molecules which serve
important roles in the human body (2).
By inhibiting these different subtypes of phosphodiesterase, cAMP and cGMP levels can be increased in different tissues where various beneficial effects can be seen, the cumulative effect of which can potentially be improved strength and body composition.
First, by inhibiting the cAMP-phosphodiesterase in skeletal muscle, it is thought that an anti-catabolic effect can be seen by suppressing calcium and ATP-dependent proteolysis, a mechanism that is shared by compounds like clenbuterol (3-10).
By increasing intracellular cAMP in skeletal muscle and the consequential decrease in calcium and ATP-dependent proteolysis, a net positive protein balance may occur in muscle, allowing for a possible gain of muscle mass.
This is a rarely-exploited natural anti-catabolic/anabolic pathway...and a VERY exciting one to say the least...and we aren't even close to being done...
Potential Fat Loss Too?
Furthermore, by increasing cAMP in fat cells, lipolysis (fat breakdown) can also increase, potentially resulting in a loss of fat...
In fact, animal model studies and traditional Asian medicine have noted this exact thing, demonstrating increased lipolysis and anti-obesity properties (11-13).
That's Not All Folks – More MOA's
Amino & Glucose Transport
In addition to these effects, by inhibiting other subtypes of phosphodiesterase a vasodilatory effect can occur, allowing for increased amino acid and glucose transport to skeletal muscle, potentially enhancing recovery and muscle growth (2,14-17).
Pumped To The Gills While Cutting?
In addition, this vasodilatory effect can potentially lead to greater "pumps" and the feeling of fuller muscles, while also potentially increasing lipolysis (2,18).
Keeps Going Like That Bunny
Unlike various nitric oxide (NO) products which can lose their effectiveness over time, these compounds will not do so.
Synergystic with Nitric Oxide Products?
In fact, these compounds may prevent N.O. products from losing their effectiveness in the first place (19-23).
Additionally, these compounds may even increase or potentiate the effects of nitric oxide products(24).
How so, you ask?
Well, to answer that, we must look at how the beloved nitric oxide (N.O.) molecule allows for vasodilation and the subsequent benefits...
N.O. is involved in the NO/guanylyl (guanylate) cyclase/cyclic GMP-dependent cascade...
In effect, it is thought that the N.O. molecule works by binding to and activating soluble guanylyl (guanylate) cyclase, which in turn catalyzes the formation of cGMP from guanosine triphosphate (GTP).
Once the previously mentioned second messenger, cGMP accumulates intracellularly in the given cell/tissue type (in this case smooth muscle), activation of cGMP-dependent protein kinase (protein kinase G or PKG) occurs and eventually leads to vasodilation, in this particular case.
So, again, how might Pink Magic prevent N.O. products from losing their effectiveness and possibly even potentiate their effects?
Well, it appears that one mechanism behind the reduction of N.O.'s effectiveness is an increase in the activity of cGMP-phosphodiesterase, which as we discussed earlier, is responsible for degrading cGMP...
Since the body can't stop you from ingesting compounds designed to increase N.O., it does the next best thing by increasing the expression of enzymes designed to reduce the downstream effectiveness of N.O....
In effect, it decreases levels of cGMP and thus reduces the level of vasodilation and other potential benefits...
However, since Pink Magic contains compounds known to inhibit cGMP phosphodiesterase, this can not only work to prevent the decline in effectiveness of N.O. products, it may even potentiate the effects of them through the same mechanism...
You'll have that N.O. product working to increase cGMP levels, while the key ingredients in Pink Magic prevent the degradation of cGMP, allowing you to maintain and even increase the beneficial effects seen with NO products!
Yet, unlikemost N.O. products, these compounds won't succumb to decreased effectiveness through decreased cGMP levels.
Endurance
If this weren't enough, one may also notice an increase in resistance to fatigue as a result of direct effect upon skeletal muscle (i.e., cAMP accumulation in both type I [slow-twitch] and type II [fast-twitch] can result in a resistance or decrease of fatigue) and the diaphragm; furthermore, by increasing cGMP accumulation in other cell types, one can potentially increase blood flow and the contractility of the heart, also resulting in greater resistance to fatigue (14,25).
In other words, you may be able to bang out more reps!
Strong Like Bull
As if all that wasn't enough, the compounds in the product can also potentially increase strength (26).
By inhibiting one of the phosphodiesterase subtypes, the contractility of skeletal muscles is increased. It is thought that this is accomplished by increasing therelease of acetylcholine at the neuromuscular junction while also sensitizing itto acetylcholine.
The result is the potential for a substantial improvement in strength.
It's a Bird, It's a Plane, It's a Test Booster too?
Massularia Acuminata
At this point, it can't get much better, can it? You bet your ass it can...
Massularia acuminata is a plant that has long been used in parts of Africa as an aphrodisiac...
Recent evidence suggests that these aphrodisiac properties noted anecdotally in humans, are due to the plant's ability to increase endogenous testosterone levels.
In a study in animal models, an aqueous extract of the plant was shown to increase serum luteinizing hormone and testicular testosterone levels by approximately 66% and 60%, respectively, relative to controls, after 3 weeks of administration in the highest dose group (1).
The increase in testosterone was found to be a dose-dependent effect, increasing significantly with each dose escalation.
In addition, other androgenic markers also indicated that the plant was effective in this regard, including a significant increase in testes-bodyweight ratio.
The authors of the study concluded that the use of the plant as an aphrodisiac is likely tied to its androgenic potential (i.e., ability to increase testosterone levels), based upon these data gathered in an animal model.
All of these effects were demonstrated without any note of adverse effects.
That's right, a potent natural test stimulator as an "added benefit" - wow!
How do ya like them apples? Even if you hate apples, you're lovin' the sound of this...
You Better Bring Your "A" Game
