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Involvement of Niacin, an essential B vitamin, in cellular energy production means that it is essential for healthy cardiovascular function, nervous system function, and immune function. Niacin nutritionally supports cholesterol levels already within the normal range.* Niacin in doses over 50 mg can cause flushing - red and itchy face and neck - when ingested in a non-time release form. Niacin Flush Free comes in time-release tablets and have less flushing reaction. These products release niacin slowly throughout the intestinal tract, which still presents the liver with a large niacin load. Simple, time-released niacin products have been associated with elevated liver enzymes in some users.