Synephrine Side Effects

Synephrine / bitter orange may speed up the heart rate and raise blood pressure. There have been reports of fainting, heart attack, and stroke in healthy people after taking bitter orange supplements alone or combined with caffeine. People should avoid taking bitter orange supplements if they have a heart condition or high blood pressure, or if they are taking medications (such as MAO inhibitors), caffeine, or other herbs/supplements that speed up the heart rate. (source).

Synephrine has also caused variant angina.

Is Synephrine safe?

There are no viable safety studies on synephrine, and until we find some, we do not consider it safe due to the issues listed above, and don't recommend its use.

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