Synephrine Benefits

It is difficult to determine if synephrine or bitter orange help with weight-loss because we cannot find studies which isolate its use or combine it with just caffeine.

An extensive online search on citrus aurantium identified only 1 eligible randomized placebo controlled trial, which followed 20 patients for 6 weeks, demonstrated no statistically significant benefit for weight loss, and provided limited information about the safety of the herb.

However, some studies have been done on VPX Meltdown, which contains synephrine among many other ingredients (Specifically, three capsules of Meltdown contains 317 mg of a proprietary blend of caffeine anhydrous, ?-methyl tetradecylthioacetic acid, yerba mate extract, and cAMP; 20 mg of methyl-synephrine HCl, 138 mg of a proprietary blend of ?-methylphenylethylamine and methyl-?-phenylethylamine; 9 mg of a proprietary blend of 11-hydroxy yohimbine, yohimbine HCl, and ?-yohimbine; 20 mg of methyl-hordenine HCl).

These studies showed that Meltdown increased resting energy expenditure, decreased respiratory exchange ratio, and enhances fat oxidation for several hours after ingestion without changing heart-rate or blood pressure.

Another study on Meltdown showed that there was a 28.9% difference in V02 for three hours after taking Meltdown, significant increase in energy expenditure, heart-rate and blood pressure (systolic, but not diastolic) was significantly elevated between hours 2 and 3, and there were increases in tension and confusion.

However, the success of VPX Meltdown could possibly be attributed to the yohimbe extract and caffeine, and more studies are needed on synephrine itself. Regardless, if you are 100% healthy and looking for an edge, the products in this category may halp you.

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