L-Leucine Side Effects

There are virtually no side effects when using branched-chain amino acids. The study linked there infused a very high amount of BCAAs with no harm.

However, you should never administer branched-chain amino acids to ALS patients (Amyotrophic lateral sclerosis, also known as Lou Gehrig's disease). A BCAA study on ALS patients had to be stopped because the ALS patient mortality rate increased substantially. No BCAA studies on healthy individuals, however, caused any adverse side effects whatsoever.

Is L-Leucine safe?

BCAA supplementation is completely safe, except for ALS patients as mentioned above. It is even safe for those with kidney and livery problems. Some of those problems are actually caused by BCAA deficiency, not by BCAA excess.

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